Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 108 for “"TLRs"”.
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ST2 & TLRs: coordination of chemokine-driven immunity
… molecules by Toll-like receptors (TLRs) is instrumental to the induction and regulation of an inflammatory response. However, prolonged or inappropriate stimulation of TLRs is associated with disease. A family of molecules coded for by the ST2 gene have been implicated as negative …
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Toll-like receptor expression and signalling in rat trigeminal neurons: Consequences for oral infection and mechanisms of orofacial pain.
The activation of Toll-like receptors (TLRs), expressed by peripheral sensory neurons, represents an innate surveillance function of sensory neurons with important consequences for neuronal function. Despite recent advances, many properties of neuronal TLRs remain poorly understood, particularly …
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Expression and Function of Toll-Like Receptor 2 and 4 in Human Melanocytes
Toll-like receptors (TLRs) are crucial players in the innate immune response to microbial invaders. There have been reported that keratinocyte TLRs represent the first barrier against exogenous pathogens in human skin. Recently, it was reported that melanocytes not only function melanin synthesis …
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The role of Toll-like receptors in Parkinson's disease
… and may be mediated by Toll-like receptors (TLRs). TLRs are pattern recognition receptors with the ability to detect damage-associated molecular patterns. The activation of TLRs, potentially occurring through the detection of aggregated α-synuclein, triggers the release of pro-inflammatory …
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건선 피부에서 Toll-like receptors와 antimicrobial peptides의 발현과 혈청 내 비타민 D과의 관계
… keratinocytes. Vitamin D, Toll-like receptors (TLRs), and antimicrobial peptides (AMPs) such as human beta defensins (HBDs) and cathelicidins (LL-37) can modulate the immune system through a variety of ways in psoriasis. Purpose: The objective of the present study was to determine, whether …
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Role of Toll-like receptors in airway inflammation
Toll-like receptors (TLRs) are germline-encoded pathogen-recognition receptors that detect different microbial structures and activate the immune system. The human TLR family presently comprises ten members (TLR1-TLR10), each with distinct properties. Although the TLRs protect the host from …
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MAPPIT analysis of the early events in Toll-Like receptor signalling
… waarvan de familie van de Toll-Like receptoren (TLRs) de belangrijkste zijn. TLRs herkennen een brede waaier aan bacteriële en virale structuren zoals lipopolysaccharide, dsRNA of bacterieel DNA. Deze structuren worden vaak pathogeen-geassocieerde moleculaire patronen of PAMPs genoemd. PAMPs zijn …
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Targeting Primary Cilia Immune Receptor Proteins for the Treatment of Polycystic Kidney Disease Mechanisms
… and target the immune reactive proteins i.e. TLRs in the primary cilia. By targeting those primary cilia immune reactive proteins using suitable agonist and antagonists to study the control of cystic formation and their progression mechanisms.</p> <p><strong>Methods: </strong>To target the …
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THE ROLE OF P24 PROTEINS IN THE ER TO GOLGI TRANSPORT OF TOLL-LIKE RECEPTORS
Toll-Like Receptors (TLRs) play a pivotal role in immunity by recognizing conserved structural features of bacterial or viral origin and regulate the initiation of the innate immune response. TLR signaling is subjected to a dynamic and complex regulation that remains poorly understood. Our research …
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Toll-like Receptors 2 and 9 Are Important for Innate Immune Cell Activation and Recruitment in Hypersensitivity Pneumonitis
… cytokine production. Toll-like receptors (TLRs) 2 and 9 recognize conserved molecular patterns present in bacteria, and signal through the adaptor molecule MyD88. The goal of my project is to investigate the role of TLRs 2 and 9 in the pathogenesis of HP during the acute phase, …
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An In Vitro Assessment of The Potential for Engineered Nanoparticles to Modulate Innate Immunity
… recognition of ENPs by Toll-Like Receptors (TLRs) may trigger an innate immune response through activation of the Nuclear Factor-kappa B (NF- κB) transcription factor. To test the capacity of ENPs to stimulate this transcription factor in vitro, two Human Embryonic Kidney cell lines (HEK293) …
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Structural basis of membrane targeting and regulation of the innate immunity adaptor TIRAP by its phosphoinositide-binding motif
Toll-like receptors (TLRs) are the main components of the innate immunity. Pathogen-activated TLRs trigger a cytoplasmic signaling cascade through adaptor proteins, with the first being the TIR domain-containing adaptor protein (TIRAP). TIRAP contains a TIR domain, which associates with TLRs and …
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The Diversity of TLR4-triggered Responses in Mouse Microglia
… verwenden Mikroglia Toll-like Rezeptoren (TLRs), welche sowohl exogene als auch endogene "Gefahren" erkennen. Die Stimulation der mikroglialen TLRs resultiert in einer angeborenen Immunreaktion, welche den Schutz des ZNS sowie die Unterstützung von Reparaturprozessen an geschädigten Geweben …
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Identifying TRAF1 Mutations as a Key Step to Develop a Targeted Therapy for Rheumatoid Arthritis
… regulator of NF-κB, whereas downstream of TLRs, TRAF1 acts as a negative regulator of NF-κB. TRAF1 negatively regulates NF-κB by sequestering the Linear-Ubiquitin Assembly Chain Complex (LUBAC). Recent work in the lab has identified the exact sites of interaction of human TRAF1 in both …
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Defining the mechanisms of microbial sensing among members of the toll-like receptor 2 sub-family
… the innate immune system, Toll-like receptors (TLRs) sense microbial components and mediate cell activation leading to protective inflammatory responses. TLRs are type-1 transmembrane receptors that are activated by forming dimers; an event driven by the coordinate binding of a cognate microbial …
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Host Inflammatory Pathways in Malaria Infection: Potential Therapeutic Targets and Biomarkers of Disease Severity
… coupled. Activation of Toll-like receptors (TLRs) by purified parasite components increased internalization of parasitized erythrocytes, but uptake of parasitized erythrocytes did not require TLRs, nor did it trigger cytokine production via TLRs or other receptors. Two candidate molecules – …
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The evolution of immune genes in tsetse flies (Glossina) and insights into tsetse-symbiont-trypanosome interactions
… each of the six Glossina genomes. A total of six TLRs were confirmed within the Glossina genome, and three additional TLRs were potentially identified, though these are unconfirmed. The evolutionary history of the attacin cluster remains undetermined, however concerted evolution likely impacts the …
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Effects of Vitamin D on Expression of Toll-like Receptors of Monocytes from Patients with Behcet's Disease
… roles in the pathogenesis. Toll-like receptors (TLRs) are involved in the initiation of innate immune response in several immune mediated inflammatory disease including BD by sensing the various microorganisms and triggering the signalling pathways, causing release of cytokines. Recent studies …
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Evolutionary analysis of Suidae TLR signaling pathway
… defense against pathogens. Toll-like receptors (TLRs) are the best characterized pathogen recognition receptors (PRRs) of the innate immune system. TLRs detect distinct pathogen associated molecules and engage downstream intracellular signaling cascades eventually leading to an innate immune …
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