Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"TLR9"”.
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Design of vaccine nanotechnology-based delivery systems, the effect of CpGODN TLR9 agonist-protein antigen conjugates anchored to liposomes
… in the field, the effect of conjugation of TLR9 to antigen in combination with liposomes on the immunogenicity of protein-based vaccines has not been explored yet.In this present study, thiol-maleimide chemistry was utilised for the covalent ligation between protein antigen and CpGODN TLR9 …
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Equine innate and adaptive immunity to viral infections
… also enhance antigen-specific adaptive immunity. TLR9 is an endosomal receptor for unmethylated bacterial and viral cytosine-phosphate-guanine DNA (CpG-DNA). West Nile virus (WNV) infection may result in meningitis and encephalitis in humans and horses, especially aged and immunocompromised …
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Immunostimulatory properties and mechanisms of action of encapsulated methylated cpg oligodeoxynucleotides
… the triggering of the endosomally localized TLR9 by a poorly understood mechanism. The immunopotency and broad range of activity of CpG ODN makes it a promising immunotherapeutic for the treatment and prevention of cancer and other diseases. However, rapid degradation of ODN by serum …
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Isolation of innate immune response genes, expression analysis, polymorphism identification and development of genetic markers for linkage analysis in common carp (Cyprinus carpio)
… TLR2, TLR3a, TLR3b, TLR4a, TLR4b, TLR7a, TLR7b, TLR9, TLR21, TLR22, MyD88a, MyD88b, TRAF6a, TRAF6b, type I IFN, IL-1β, IL10a and IL10b. Putative SNPs were genotyped in a SNP discovery panel consisting of different common carp strains and koi to evaluate their allele frequencies and in a full-sib …
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Characterization of Lung Inflammation Induced by Exposure to Fipronil
… staining in the airway epithelium. Similarly, TLR9 stained lungs showed that orally treated animals had reduced TLR9 reaction in the airway epithelial cells but intranasally exposed animals had intense TLR9 staining in the alveolar septa and airway epithelium. The slides were also scored …
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Periodontal bacterial-DNA initiated immuno-inflammatory responses in human osteoblastic cells
… (bDNA) is one of the PAMPs mainly recognized by TLR9. Interaction of bDNA and its receptors leads to activation of inflammatory signaling pathways potentially resulting in periodontal bone destruction. The aim of this study was to determine the production of IL- 6 and IL-8 in response to …
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Investigation into the genetic variation of Toll-Like Receptor 9 in cattle using both Sanger and next-generation sequencing from FTA-Cards
… the genetic variation of Toll-like receptor 9 (TLR9) was investigated; this gene is known to have a function in parasite recognition. In a previous study from the Hide lab, 80 bovine blood samples were collected from bulls in Ahoada, Nigeria and the samples were stored on Whatman FTA cards. In …
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IMPAIRMENT OF TOLL-LIKE RECEPTOR 9 AGONIST ANTI-TUMOR ACTIVITY BY ANTI-PD-1 ANTIBODY: ROLE OF MACROPHAGES
… Gli agonisti del recettore Toll-like 9 (TLR9) sono noti per la loro capacità di attivare le cellule del sistema immunitario innato e sono stati ampiamente studiati per il trattamento di diversi tipi di tumore. Tuttavia, ad oggi non sono stati raggiunti risultati soddisfacenti. Infatti, …
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CD40 stimulation activates ‘post-activated’ B Cells which are hyporesponsive to B Cell receptor and toll-like receptor 9 stimulation in autoimmunity
… reduced responsiveness of SLE B cells to TLR9 stimulation which recognizes nuclear antigens and is considered key in self-tolerance brake to nuclear antigens together with the BCR [22-25]. T cell help by CD40-CD40L binding drives germinal center (GC) reaction and the development of long …
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Characterisation and therapeutic modulation of toll-like receptor signalling in response to the intracellular pathogen F. tularensis
… receptors. The contribution of TLR2, TLR4 and TLR9 to the immune response to F. tularensis infection was examined using KO cell lines and specific antagonists. TLR2 was confirmed as a receptor for F. tularensis and was observed to play a role in the translational regulation of TNF. A role for …
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Targeting Primary Cilia Immune Receptor Proteins for the Treatment of Polycystic Kidney Disease Mechanisms
… target the ciliary immune TLR proteins (TLR4 and TLR9), we did immunostaining to evaluate their localization on primary cilia. Cilia lengths were measured and compared using differential interference contrast (DIC) and fluorescent imaging techniques. The <em>in vitro</em>3D cyst progression was …
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Compartmental responses of the respiratory tract to Staphylococcus aureus
… cells and the response to stimulation with the TLR9 agonist CpG-C ODN was assessed in these cells as well as in primary human type II alveolar epithelial cells. Subjects were also assessed for nasal carriage of S. aureus and their associated cytokine responses. RESULTS: The RPMI 2650 cell line, …
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Investigation of the immunostimulatory activity and vaccine potential of lipid encapsulated plasmid DNA and oligodeoxynucleoties
… activity in Toll-like receptor 9 (TLR9) knock-out mice. Together theses findings highlight the need for DNA-based therapies to consider both TLR9-dependent and -independent immunostimulatory activities of pDNA when constructing non-viral vectors. Furthermore, a new role for SPLP as …
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Designing 3D Wireframe DNA Nanoparticles for Programmable Innate Immune Activation
… expression primarily through cGAS-STING, while TLR9 is very minimally activated. I then enhance the ability of these nanoparticles to activate TLR9 by attaching discrete copy numbers of immunostimulatory CpG motifs at precise spatial positions and show that activation levels can be controllably …
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Mechanisms of Immunomodulation By Probiotics: Influence of Lactobacilli On Innate and T Cell Immune Responses Induced By Rotavirus Infection and Vaccines
… and HRV had an additive effect on TLR2- and TLR9-expressing APC responses, consistent with the adjuvant effect of lactobacilli. Dose effects of LA on T cell immune responses were investigated. We found that low dose LA significantly enhanced frequencies of HRV-specific IFN-γ producing CD4⁺ …
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Mitochondrial damage-associated molecular patterns (DAMPs) in inflammatory bowel disease
… transmission electron microscopy (TEM) and (b) TLR9 expression, the target for mtDNA. Results 97 patients with IBD (67 UC and 30 CD), and 40 non-IBD controls were recruited. Plasma mtDNA levels were increased in UC and CD (both p<0.0001) compared to non-IBD controls; with significant …
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Role of Toll-like receptors in airway inflammation
… of the virus-sensing receptors TLR3, TLR7 and TLR9 was shown in eosinophils. Stimulation with the cognate ligands gave rise to an activation manifested by an increased eosinophil survival, release of damaging mediators and ability to migrate to inflamed areas. It was also found that the …
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The ability of TLR agonists to upregulate Brucella abortus strain RB51 mediated protection in a murine respiratory model
… The addition of TLR 2 or TLR 4 and a trend with TLR9 agonists with intranasal RB51 vaccination significantly increased bacterial clearance in the lung after strain 2308 challenge. Therefore, we hypothesized that combining TLR agonists 2, 4, and 9 with strain RB51 IN would upregulate protection …
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Allergen Sensitization and Immunomodulation By Synthetic Ligands, Pul-042, In An Allergen-Induced Asthma Murine Model
… of two agonists against TLR2/6 heterodimer and TLR9. Previous studies have evaluated PUL-042 for its ability to confer resistance against bacterial and viral lung infection. These findings, combined with studies performed using CpG ODNs, led to speculation that PUL-042 dampens the immune …
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Investigating The Roles of Lung Epithelial Stat3 In Therapeutically Inducible Resistance to Acute Bacterial Pneumonia.
… An inhaled combination of a TLR2/6 agonist and a TLR9 agonist (Pam2ODN) results in robust protection against otherwise lethal pneumonia caused by <em>Pseudomonas aeruginosa</em>. Pam2ODN-mediated protection requires key signaling components of the TLR pathway and generation of multisource reactive …
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