Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 15 of 15 for “"TLR4 signalling"”.
-
Activation of the TLR4 Signalling Complex by the Ebola Virus Glycoprotein
… LPS sensor with protective pro-inflammatory signalling, has been identified as the source of hyperinflammation during Ebola virus infection. The molecular basis of TLR4 agonism by GP1,2 and also other viral proteins is unknown to date, and this body of work goes some way to explore this …
-
Exploring the oligomeric state of TLR4 and downstream regulators RIPK1 and RIPK3
… (TIR) domain, which builds a platform for signalling via the MyD88- and TRIF-pathway. TLR4, with its co-receptor MD2, unlike the other TLRs, can signal via the MyD88- and TRIF-pathway when activated by LPS as well as non-LPS ligands such as the Zaire ebolavirus glycoprotein. Key regulators …
-
Follow your gut: Does AKR1D1 impact gastrointestinal health?
… disrupt cytoprotective intestinal bile acid signalling and drive gut dysbiosis, impairing intestinal barrier function and inducing hepatic inflammation. We have previously shown that expression of the bile acid synthesis enzyme 5β-reductase (AKR1D1) is decreased in patients with NAFLD. In …
-
Role of the Gut Microbiome in Cancer Immunotherapy Efficacy and Side Effects
… Gram-negative bacteria and TAK-242 to inhibit TLR4 signalling in MC38 tumour-bearing mice, the study demonstrated that hexa-acylated LPS enhances anti-PD-1 efficacy via TLR4 signalling, whereas penta-acylated LPS has minimal effects. These findings suggest that gut microbial composition and LPS …
-
Characterisation of the role of Fas in intestinal inflammation and cancer
… of crosstalk exists between the Fas and TLR signalling pathways but this has not yet been investigated in the intestine. Aim: The aim of this study was to evaluate potential cross-talk between TLRs and Fas/FasL system in intestinal cancer cells. Results: Treatment with TLR4 and TLR5 ligands, …
-
Investigating the role of toll-like receptor 4 in myocardial ischaemic-preconditioning and ischaemic-reperfusion injury
… investigates the role of toll-like receptor 4 (TLR4), an immunosurveillance receptor, in both myocardial ischaemic-reperfusion injury and ischaemic-preconditioning. Receptor activity is triggered when DAMPs (danger associated molecular pattern molecules) are released from necrotic cells and bind …
-
Microglial activation and regulation by secreted chaperones
… microglia by stimulating toll-like receptor 4 (TLR4) signalling, as nanomolar calreticulin could not activate microglia or a TLR4 reporter line when i) intracellular TLR4 signalling was blocked, ii) binding to TLR4 was blocked with function blocking antibodies, or iii) the hydrophobic binding …
-
Exploring the bidirectional interface between stress and innate immunity: a focus on glucocorticoid and TLR4-MyD88 signalling
… immunity, by focusing on glucocorticoid and TLR4- MyD88 signalling. The research was undertaken in a series of 3 studies. Study 1 investigated the impact of baseline TLR4-MyD88 signalling on the neuroendocrine and behavioural responses to acute stress. Through examining stress responses in …
-
Immunomodulatory effects exerted by Lactobacillus salivarius strains on innate immune cells
… engagement, TLRs trigger a complex network of signalling that culminate in the production of inflammatory mediators. The investigation of the molecular mechanisms underlying the Lb. salivarius-host interaction resulted in the identification of a novel role for TLR2 in negatively regulating TLR4 …
-
Development of novel imaging technology to study cell signalling
Currently it is difficult to study signalling on living cells at the single molecule level. One problem is that it is not possible to trigger signalling in a controlled manner and there is no effective method that can both introduce a precise amount of molecules onto or into a single cell at a …
-
Lysophosphatidylcholine acyltransferase-2 (LPCAT-2) & protein S-acylation in macrophage innate immunity
… innate immune responses via lipid raft signalling complexes and understanding the molecular details of these mechanisms could help in the development of targeted anti-inflammatory therapies.<br/><br/>The aim of this thesis is to build on these findings to develop a detailed molecular …
-
ST2 & TLRs: coordination of chemokine-driven immunity
… have been implicated as negative regulators of TLR4-signalling in murine cells. Here, the existence and potential role of these ST2 molecules in human macrophages has been investigated. Following the discovery of IL-33 as a ligand for ST2, the effect of this ligand on human macrophages was …
-
Proteomic analysis of TRIF interactome and functional characterisation of novel TRIF interacting proteins
… is an important adaptor protein in TLR3 and TLR4 signalling pathways that mediate proinflammatory cytokine and IFN responses following their activation by doubled-stranded RNA and LPS, respectively. In the present study, we sought to investigate the novel proteins and pathways that serve to …
-
The role of adaptor protein Mal/TIRAP in transducing TLR signalling
Toll-like receptor 4 (TLR4) plays an essential role in the innate immune system, protecting the body from gram-negative bacteria. However, while TLR4 activation is essential for host defence, it can also drive harmful inflammatory responses, contributing to conditions such as sepsis. Understanding …
-
The effects of ES-62 on DC maturation and effector function
… CpG, which is known to activate pDCs, and LPS, a TLR4 ligand which is reported to have no effect on such pDCs, and the ability of such differentially activated pDC phenotypes to prime Ag-specific T cells were studied. Whilst only low levels of cytokines were produced by pDC upon stimulation with …