Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 16 of 16 for “"TLR4 signaling"”.
-
Role of Redox-Active Trace Metal (RATM) Oxidants in the Regulation of Toll-Like Receptor 4 (TLR4) Signaling-Mediated Inflammatory Phenotype in Synovial Fibroblasts
… that oxidant-induced Toll-like receptor 4 (TLR4) activation plays a significant role in initiating “sterile” inflammation. Here, we investigate for the first time the role of RATM-induced oxidant stress in the molecular mechanism of the pathogenesis of RA. Potassium peroxychromate (PPC) …
-
Immunological Impact of CLI-095 on Dendritic Cell Maturation and Hypoxia-re-oxygenation induced inflammatory injury
… Receptors (TLRs) by endogenous ligands. TLR4 expressed within the kidney is a potential mediator of innate activation and inflammation. Stimulation of TLR4 induces distinct patterns of gene expression, which not only leads to the activation of innate immunity but also to the development …
-
Endotoxin-induced microRNA expression in equine peripheral blood mononuclear cells
… (LPS) mediated by toll-like receptor 4 (TLR4) contributes substantially to the morbidity of equine gastrointestinal disease, neonatal sepsis and other diseases. MicroRNAs (miRNAs), small non-coding RNA molecules acting as post-transcriptional regulators of gene expression, have key roles …
-
Phosphatidylinositol 4-phosphate 5-kinase Involved in Neuroglial Toll-like Receptor Signaling
… system. Activation of Toll-like receptor 4 (TLR4), the primary transducers of innate immune system, is critical in microglial functions. Especially, activation of microglia by lipopolysaccharide (LPS), a ligand for TLR4, has been extensively studied. It was previously demonstrated that …
-
Role Of Crebh In Endotoxin Mediated Modulation Of Hepatic Metabolism
… LPS shock in the body induces activation of the TLR4 signaling pathway in mouse liver. Upon triggering TLR4 signaling pathway, LPS stimulates cleavage and activation of CREBH transcription factor LPS induces the interaction between CREBH and TNF receptor-associated factor 6 (TRAF6), an E3 …
-
Targeting toll-like receptor 4 related inflammation using small molecule, TAK-242, to attenuate inflammatory damage in pancreatitis and islet transplantation.
… have used TAK-242, a small molecule inhibitor of TLR4 to analyze the beneficial effects of inhibition of TLR4 in pancreatitis and islet transplantation. In my fist aim I demonstrate the therapeutic potential of inhibition of TLR4 signaling in the context of sterile inflammation using a mouse model …
-
Toll-Interacting Protein Regulation of Low-grade Non-resolving Inflammation
… leukocytes may utilize distinct intra-cellular signaling circuitries modulated by adaptor molecules. Toll-interacting protein (Tollip) is one of the critical adaptor molecules in Toll-like receptor 4 (TLR4) signaling and potentially playing key roles in modulating the dynamic adaptation of …
-
The Role of Toll Like Receptor-4 in Exercise-induced Myokine Response and Regulation of Skeletal Muscle Metabolic Adaptation
Toll like receptor-4 (TLR4) is a transmembrane inflammatory receptor expressed ubiquitously on the cell surface of immune cells as well as skeletal muscle and other metabolic tissues. A compelling body of evidence shows that muscle TLR4 and the downstream cytokine signaling modulate skeletal muscle …
-
The role of dendritic cells in rickettsial infection; initation of early immunity to spotted fever group Rickettsiae
… preliminary data suggest that rickettsiae act as TLR4 agonists on dendritic cells, resulting in their activation. To elucidate the significance of dendritic cells in rickettsioses, I developed a model of dermal infection to demonstrate that cutaneous dendritic cells comprise an important initial …
-
Innate Immune Transcription Activator Interferon Regulatory Factor-3 (IRF3) Contributes to Maladaptive Remodeling Post-myocardial Infarction
… demonstrated that targeted gene knockdown of TLR4, as well as downstream adaptor proteins and kinases, significantly improve cardiac function and overall survival. While the well-known NF-κB transcriptional factor that is downstream to TLR4 signaling has been linked to remodeling, there has …
-
The Role of IRAK-1 in the Regulation of Free Radicals and Oxidative Stress during Endotoxemia
… of ROS and RNS is mediated by innate immune signaling processes. Lipopolysaccharide (LPS), a major inflammatory signal, is known to be a potent inducer of ROS/RNS. Thus, strategies that may block LPS-mediated generation of free radicals may hold promise in treating various inflammatory …
-
Limiting host-microbiota interactions to control intestinal inflammation
… a path for unchecked inflammatory responses. TLR4 signaling through both antigen-presenting cells, and on T cells themselves is capable of inhibiting regulatory T cell generation. Upon the induction of a chronically inflamed state, regulatory T cell function is altered and hinders restoration …
-
The Regulation Of Myeloid Inflammatory Responses By Runx1: Roles In Normal And Malignant Hematopoiesis
… a novel role for RUNX1 in regulating TLR1/2 and TLR4 signaling and inflammatory cytokine production by neutrophils. Hematopoietic-specific RUNX1 loss increased the production of pro-inflammatory mediators, including tumor necrosis factor α (TNF-α), by bone marrow neutrophils in response to TLR1/2 …
-
Neuropathologic characterization of a canine model of mucopolysaccharidosis IIIB and additional studies in anti-inflammatory therapy and neuroinflammatory kinetics
… receptor (TLR)4 pathway. Activation of the TLR4 pathway as a result of HS oligosaccharide accumulation has been consistently demonstrated in unaffected and MPS affected mice. To determine the neuroinflammatory environment in the MPS IIIB canine brain, we utilized cytokine ELISAs and western …
-
Low-Input and Single-Cell Transcriptomic Technologies and Their Application to Disease Studies
… regulates the TRAM-dependent pathway of TLR4 signaling, and high-dose LPS exclusively upregulates exhaustion markers by impacting metabolic and proliferative pathways.
-
Effect of IBC isolated from Psoralea corylifolia on expression of adhesion molecule-1 in cerebrovascular endothelial cells
… into nucleus and NF-kB transcriptional activity. TLR4 conveys LPS-signal to intracellular compartment via MyD88- and TRIF-dependentpathways,whichculminateintheactivationofNF-kB. As well as, IBC attenuated MALP-2 (a TLR2, 6 specific ligand)-induced ICAM-1 expression, IkB-alpha phosphorylation and …