Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"TLR4 pathway"”.
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TLR4 is a novel determinant of the response to paclitaxel in breast cancer
… ability of PXL to activate Toll-like Receptor-4 (TLR4) pathway. TLR4 is activated by lipopolysaccharide (LPS) and other ligands including the widely used drug PXL. TLR4 is often over-expressed in malignant epithelial cells in which its signaling hyper-activates NF-kB, MAPK and PI3K pathways …
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Respiratory Biomarkers in Kv1.1 Knockout Mice, a Model for Temporal Lobe Epilepsy
… inflammation activated in toll-like receptor 4 (TLR4) pathway are associated with apnea and respiratory failure, therefore we determined whether an inflammatory pathology is apparent in lung tissue in older, KO mice that are at high-risk for SUDEP and wildtype (WT) control littermates treated …
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COMPARISON OF E. COLI AND Y. PESTIS LPS TLR4 TIME COURSE ON P388D1 MACROPHAGES USING FLUORESCENT CONJUGATED ANTIBODIES
… system. It has been shown that LPS-induced TLR4 dimerization and clustering correlate to an appropriate innate immune response. Imaging the degree of TLR4 clustering after exposure to different gram negative LPS can further the understanding of TLR4 pathway dynamics. By studying the …
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TLR4 expression on equine B lymphocytes: a clue to LPS sensitivity?
… which is recognized by Toll-like receptor 4 (TLR4). In cases where epithelial barriers are compromised or breached LPS has the potential to enter circulation and cause the inflammatory symptoms seen with endotoxemia. The objective of this study was to determine TLR4 presence and functionality …
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Impact of endotoxemia on ovarian signaling and function
… endotoxemia upregulates toll-like receptor 4 (TLR4) pathways, as well disrupt insulin signaling and steroidogenesis in the ovary. To test this central hypothesis, various animal models; pre- and post-pubertal gilts, as well as lactating cows, were exposed to HS and/or LPS to perturb intestinal …
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A novel bioinformatic approach for comprehensive genome scale analysis identifies key regulators of macrophage activation.
… activation by the Toll-like Receptor 4 (TLR4) pathway is initiated with receptor binding of lipopolysaccharides (LPS) and culminates in a large-scale transcriptional response of the inflammatory gene program. Advancements in genome-wide screening technologies have made it possible to …
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Molecular mechanisms responsible for the dynamic modulation of macrophage responses to varying dosages of lipopolysaccharide
… LPS is recognized by the Toll-like receptor 4 (TLR4), activating a signaling pathway which triggers the production of both pro- and anti-inflammatory mediators. Very low doses of LPS, however, preferentially induce pro-inflammatory cytokines, which can lead to persistent low-grade inflammation, …
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Suppression of pro-inflammatory signalling pathways by sulforaphane
… residues 609 and 246 within the LPS receptor, TLR4 under non-reducing conditions, to reduce the levels of inflammatory mediators that are produced in response to LPS. The anti-inflammatory effect of SF was not restricted to the TLR4 pathway, and significant reductions were observed in NF-κB …
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The role of Toll-like Receptor 4 in the Modulation in Skeletal Muscle Metabolism
Toll-like receptor 4 (TLR4) is a transmembrane receptor, which upon activation by lipopolysaccharide (LPS) from Gram-negative bacteria, plays an important role in the induction of the innate immune response. Our lab has previously demonstrated that activation of TLR4 in skeletal muscle results in …
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The Role of Fatty Acids on Toll-like Receptor 4 Regulation of Substrate Metabolism with Obesity
… responses. Our laboratory has observed that TLR4 expression is elevated in the skeletal muscle of obese humans and is associated with reduced fatty acid (FA) oxidation and increased lipid synthesis. Additionally, activation of this pathway by lipopolysaccharide (LPS), ex vivo, results in a …
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Dose-dependent effects of endotoxin on monocyte and the underlying mechanisms
… in monocytes is dependent on non-traditional TLR4 adaptor called TRAM. In the second project, we focused on the effects of high dose endotoxin on monocyte phenotypes. We reported that high dose endotoxin give rise to a mix of both immunosuppressive and pathogenic inflammatory monocytes, …
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Exploring the oligomeric state of TLR4 and downstream regulators RIPK1 and RIPK3
… platform for signalling via the MyD88- and TRIF-pathway. TLR4, with its co-receptor MD2, unlike the other TLRs, can signal via the MyD88- and TRIF-pathway when activated by LPS as well as non-LPS ligands such as the Zaire ebolavirus glycoprotein. Key regulators in the TLR4 pathway are RIPK1 and …
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Neuropathologic characterization of a canine model of mucopolysaccharidosis IIIB and additional studies in anti-inflammatory therapy and neuroinflammatory kinetics
… is thought to occur through innate inflammatory pathways, such as the toll-like receptor (TLR)4 pathway. Activation of the TLR4 pathway as a result of HS oligosaccharide accumulation has been consistently demonstrated in unaffected and MPS affected mice. To determine the neuroinflammatory …