Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 179 for “"TLR4"”.
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The Diversity of TLR4-triggered Responses in Mouse Microglia
… Ziel hat. Innerhalb der TLR Familie nimmt der TLR4 eine besondere Stellung ein. Dies ist in erster Linie durch die duale Benutzung der beiden TLR Signalwegsassoziierten Adaptermoleküle MyD88 und TRIF gekennzeichnet. Die vorliegende Arbeit beschäftigte sich mit der mikroglialen Reaktion nach …
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Activation of the TLR4 Signalling Complex by the Ebola Virus Glycoprotein
… Ebola virus infection. The molecular basis of TLR4 agonism by GP1,2 and also other viral proteins is unknown to date, and this body of work goes some way to explore this interaction. This thesis explores the Ebola virus glycoprotein and the associated hyperactivation of the TLR4 signalling …
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TLR4 expression on equine B lymphocytes: a clue to LPS sensitivity?
… which is recognized by Toll-like receptor 4 (TLR4). In cases where epithelial barriers are compromised or breached LPS has the potential to enter circulation and cause the inflammatory symptoms seen with endotoxemia. The objective of this study was to determine TLR4 presence and functionality …
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Exploring the oligomeric state of TLR4 and downstream regulators RIPK1 and RIPK3
… for signalling via the MyD88- and TRIF-pathway. TLR4, with its co-receptor MD2, unlike the other TLRs, can signal via the MyD88- and TRIF-pathway when activated by LPS as well as non-LPS ligands such as the Zaire ebolavirus glycoprotein. Key regulators in the TLR4 pathway are RIPK1 and RIPK3, …
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TLR4 is a novel determinant of the response to paclitaxel in breast cancer
… ability of PXL to activate Toll-like Receptor-4 (TLR4) pathway. TLR4 is activated by lipopolysaccharide (LPS) and other ligands including the widely used drug PXL. TLR4 is often over-expressed in malignant epithelial cells in which its signaling hyper-activates NF-kB, MAPK and PI3K pathways …
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Structural and ligand binding studies of toll-like receptor 4 (TLR4) associated proteins
… complex comprised of Toll-like receptor 4 (TLR4) and myeloid differentiation antigen (MD-2). As described in Chapter 1, LPS-dependent complex formation of TLR4/MD-2 heterodimers results in the activation of pro-inflammatory signaling cascades. Although inflammation is usually host …
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Stimulation Through Tlr4 Increases Fviii Inhibitor Formation In A Mouse Model of Hemophilia A
… I hypothesized that stimulation through TLR4 in conjunction with FVIII treatments would increase the formation of FVIII inhibitors. To test this hypothesis, FVIII K.O. mice were injected with recombinant human FVIII with or without concomitant doses of TLR4 agonist (lipopoysaccharide; …
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Inhibition of TLR4 minimizes islet damage due to sterile inflammation and improves islet transplant outcomes.
… as 50% of the islet graft. Toll-like receptor 4 (TLR4) has been identified as a major pro-inflammatory mediator of sterile inflammation by sensing damage-associated molecular patterns (DAMPs) and compromising graft function, making it a putative therapeutic target. Here, we study the effects of …
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Mechanisms of Immuno-Modulation With The TLR4 Agonist Monophosphoryl Lipid A in the Treatment of Sepsis
… well as potential signaling pathways involved in TLR4 immmuno-modulation. Mice received either intravenous or intraperitoneal treatment with MPLA prior to induction of bacterial peritonitis by cecal ligation and puncture (CLP), intraperitoneal or intravenous infection with Pseudomonas aeruginosa, …
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Bats and their endoparasites : characterising pipistrelle infections and toll-like receptor (TLR2 and TLR4) gene variations
… system, a PCR strategy was developed to isolate TLR4 and TLR2 genes from the pipistrelle bats (n=59). The TLR4 sequences were highly variable at the amino acid level (haplotypes, n=42), and a phylogenetic analysis of the protein sequences showed that they clustered into 7 major groups. Analysis …
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Exploring the bidirectional interface between stress and innate immunity: a focus on glucocorticoid and TLR4-MyD88 signalling
… immunity, by focusing on glucocorticoid and TLR4- MyD88 signalling. The research was undertaken in a series of 3 studies. Study 1 investigated the impact of baseline TLR4-MyD88 signalling on the neuroendocrine and behavioural responses to acute stress. Through examining stress responses in …
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COMPARISON OF E. COLI AND Y. PESTIS LPS TLR4 TIME COURSE ON P388D1 MACROPHAGES USING FLUORESCENT CONJUGATED ANTIBODIES
… system. It has been shown that LPS-induced TLR4 dimerization and clustering correlate to an appropriate innate immune response. Imaging the degree of TLR4 clustering after exposure to different gram negative LPS can further the understanding of TLR4 pathway dynamics. By studying the …
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Design, Synthesis, and Evaluation of Covalent CADA Analogues as Potent TLR4 Downmodulator for the Treatment of Opioid Use Disorder
Toll-Like Receptor 4 (TLR4) is involved in the innate immune response and the pathogenesis of opioid use disorder (OUD). Opioids interact not only with neuronal sites but also with glial cells thereby activating these cells, thus leading to the release of neuroexcitatory substances and …
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TLR4 endogenous ligand S100A8/A9 levels in adult-onset Still’s disease and their association with disease activity and clinical manifestations
Objective: S100A8/A9 has been suggested as a biomarker of disease activity in patients with systemic juvenile idiopathic arthritis or adult-onset Still’s disease (AOSD). We investigated the clinical significance and the pathogenic role of this marker in AOSD. Materials and Methods: Serum samples …
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Expression of functional active Toll like receptor 4 in normal and adenomatous pituitary cells
… und Bedeutung des Toll-like Rezeptors 4 (Tlr4) in normalen und adenomatösen epithelialen Hypophysenzellen untersucht. Tlr4 ist der Rezeptor für bakterielle Lipopolysaccharide und ist daher an der Induktion der angeborenen Immunantwort bei Infektions- oder Entzündungsprozessen beteiligt, …
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Immunological Impact of CLI-095 on Dendritic Cell Maturation and Hypoxia-re-oxygenation induced inflammatory injury
… Receptors (TLRs) by endogenous ligands. TLR4 expressed within the kidney is a potential mediator of innate activation and inflammation. Stimulation of TLR4 induces distinct patterns of gene expression, which not only leads to the activation of innate immunity but also to the development …
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Role of Toll-Like Receptor 4 in Oxidant-induced Inflammatory Phenotypes in Macrophages
… study, we tested the central hypothesis that TLR4 is the link between reactive oxygen/nitrogen species (RONS), oxidative stress and inflammatory phenotypes that mediate diverse disease processes. We first characterized the mediatory role of TLR4 in exogenous oxidant induced nuclear factor-κB …
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Role of Toll-Like Receptor 4 in Pathophysiology of Hypertension
… role of toll-like receptors (TLRs), particularly TLR4 in pathogenesis of several inflammatory conditions including cardiovascular diseases are becoming evident. However, the functional im-portance of the brain TLR4 and its interaction with other molecules involved in the pathogenesis of …
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Investigating the role of toll-like receptor 4 in myocardial ischaemic-preconditioning and ischaemic-reperfusion injury
… investigates the role of toll-like receptor 4 (TLR4), an immunosurveillance receptor, in both myocardial ischaemic-reperfusion injury and ischaemic-preconditioning. Receptor activity is triggered when DAMPs (danger associated molecular pattern molecules) are released from necrotic cells and bind …
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