Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 55 for “"TLR3"”.
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Functional characterization of human and chicken TLR3
Toll-like receptor 3 (TLR3) is a critical component of the innate immune system, responsible for detecting viral double-stranded RNA (dsRNA) and initiating downstream signaling pathways, including activation of the transcription factor NF-κB. While TLR3 function has been extensively characterized …
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Einfluss rekurrierender Exposition gegenüber TLR3-Liganden auf Lungenfunktionstrajektorien
Asthma bronchiale als häufigste chronische Lungenkrankheit im Kindesalter, stellt weltweit eine führende Ursache für Morbidität und Mortalität dar. Epidemiologische Studien assoziieren wiederholte frühe respiratorische Virusinfektionen mit erhöhtem Asthmarisiko und veränderten …
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Defining the Physiological and Molecular Role of Pellino3 in TLR3 Signalling
… to double stranded viral RNA recognition by TLR3. Pellino3-deficient mice are more resistant to the pathogenic and lethal effects of encephalomycarditis virus (EMCV) infection. Pellino3 functions in a novel auto-regulatory mechanism to specifically prevent excessive TLR3 induced expression of …
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The Role of MDA5 and TLR3 in Response to dsRNA and Viral Infection
… the Rig-I-like receptors: RLR). Among the TLRs, TLR3 binds dsRNA within the endosomal compartment and initiates signaling through its downstream adapter TRIF. Melanoma differentiation-induced gene 5: MDA5) is a member of the RLR family that recognizes dsRNA within the cytosolic compartment and …
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Evasion of RIG-I/MDA5 and TLR3-mediated innate immunity by hepatitis A virus
… RIG-I and MDA5, and Toll-like receptor 3 (TLR3) are PRRs that detect virus-specific double stranded RNA (dsRNA). Activation of these PRRs by dsRNA lead to their interaction with adaptor proteins, which engage downstream kinases to activate two critical transcription factors, NF-kB and IRF3, …
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TLR3 Signaling in Human BDCA-3 Dendritic Cells Results in the Formation of Several ILT3 and ILT4 Populations
<p>Dendritic cells (DCs) represent a population of innate immune cells that are highly efficient at promoting immune responses. DCs are capable of presenting antigens to both CD4 and CD8 T cells. DC presentation and interaction with T cells can result in either immune stimulation or tolerance. This …
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Investigations into the role of Toll-Like Receptors in the modulation of the inflammatory response during Osteoarthritis
… OA pathology. Interestingly, we found that TLR3, activated by dsRNA and endogenous alarm signals contained in the OA synovial fluid (SF), plays a key role in OA and this was confirmed by neutralisation of TLR3 expression which shifted the balance from pro-inflammatory to an anti-inflammatory …
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Induction and Regulation of CXCL10 in Hepatocytes During Hepatitis C Virus Infection
… sensors of HCV infection (Toll-like receptor 3 [TLR3] and retinoic acid inducible gene I [RIG-I]) contribute to CXCL10 induction in hepatocytes. CXCL10 mRNA and protein were measured in primary human hepatocytes (PHH) and hepatocyte lines harboring functional or non-functional TLR3 and RIG-I …
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The impact of variation in the Toll-like receptor 3 gene on epizootic hemorrhagic disease in Illinois white-tailed deer (Odocoileus virginianus)
… upon infection. One of the Toll-like receptors, TLR3, recognizes pathogen-associated molecular patterns in dsRNA viruses, thus playing a key role in immune detection and response to EHDV. In this thesis, I study genetic variation within TLR3 and its association with EHD in white-tailed deer from …
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Dissecting the Novel Roles of TRIM56 in Antiviral Innate Immunity
… forms a complex with the Toll-like receptor-3 (TLR3) adaptor, TRIF, via its C-terminal residues 621-750, and augments TLR3-mediated interferon (IFN) induction and establishment of an antiviral state. Yet, TRIM56’s antiviral spectrum and the precise underlying mechanisms by which TRIM56 executes …
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Proteomic analysis of TRIF interactome and functional characterisation of novel TRIF interacting proteins
… IFN-β (TRIF) is an important adaptor protein in TLR3 and TLR4 signalling pathways that mediate proinflammatory cytokine and IFN responses following their activation by doubled-stranded RNA and LPS, respectively. In the present study, we sought to investigate the novel proteins and pathways that …
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Chlamydia pneumoniae, Toll-like Receptors and Pathogenesis of Atherosclerotic Heart Disease
… exogenous LDL for foam cell formation, whereas a TLR3 agonist induces foam cell formation even in the absence of added LDL. TLR3, but not TLR2 and TLR4 agonists, decreases the gene expression of a cholesterol effluxer, suggesting that inhibition of cholesterol efflux may be sufficient to induce …
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The role of TLR3- and MyD88-dependent signaling in the development of anti-West Nile virus adaptive immune responses induced by a vaccine candidate, RepliVAX WN.
… We examined and compared the role of TLR3- and MyD88-dependent signaling in the development of anti-WNV-specific T cell responses by examining the kinetics of WNV-specific IFN-γ secreting CD4+ and CD8+ T cell responses, the functional pattern of primary and secondary effector …
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THE ACTIVATION, RECEPTOR COMPLEXING AND ENDOGENOUS REGULATION OF THE TYPE-I INTERFERON RESPONSE AS IT PERTAINS TO INNATE IMMUNITY
… an immune response. Toll-like receptor 3 (TLR3), a transmembrane receptor found in endosomes, is vital to the innate immune response against viruses. Double-stranded RNA (dsRNA) stimulation of TLR3 initiates a signaling cascade that leads to the production of type-I interferons and …
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Molecular insights into modulation of host innate immune response by viral proteins of RNA viruses SARS-CoV, HCV and Influenza virus
… pathogen associated molecular patterns (PAMPs). TLR3, RIG-I and MDA5, trigger complex intertwined signaling pathways in response to viral dsRNA leading to the activation of interferon regulatory transcription factors IRF3, IRF7 and NF-κB. These transcription factors mediate inflammatory …
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THE ROLE OF P24 PROTEINS IN THE ER TO GOLGI TRANSPORT OF TOLL-LIKE RECEPTORS
… TMED7 interacts with TLR2 and TLR4, but not with TLR3. In contrast, TMED2 interacts with TLR2, TLR4 and TLR3. Different TLRs were co-expressed with ER-export deficient TMED7 and TMED2 and their cellular localisation observed using confocal microscopy. These data suggest that TMED7 is required for …
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Exploring the molecular basis to the regulatory effects of Cannabinoids on toll-like receptor signalling
… that R(+)WIN55,212-2, in the presence of the TLR3 ligand, Poly(I:C), targets interferon regulatory factor 3 (IRF3), a transcription factor essential for regulating type I interferon (IFN) expression. These findings also demonstrate that protective effects of R(+)WIN55,212-2 in EAE mice exist, …
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BIOCHEMICAL CHARACTERIZATION OF SUPPRESSOR OF IKK-ε AND NAK-ASSOCIATED PROTEIN 1
… innate immune response, Toll-like receptor 3 (TLR3) recognizes viral dsRNA and signals subsequent production of type-I interferon. The TLR3:interferon signaling cascades contains a kinase complex composed of two kinases and a scaffold protein, NAK-associated protein 1 (NAP1). The role of NAP1 …
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Understanding the Role of Mitochondria in Driving Antiviral Inflammatory Responses
… viral ligands (TLR7 ligand; mimics ssRNA) and (TLR3 ligand; mimics dsRNA). In young cells, TLR7 engagement was associated with high levels of inflammatory cytokine production dependent on glycolysis for ATP production. TLR3 engagement was associated with a robust type I IFN response, requiring …
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Viral and Cell Type Specific Host Factors that Contribute to Paramyxovirus Antiviral Responses
… that cytokine induction did not involve TLR3. However, IL-8 secretion was enhanced when mutant virus infected cells were challenged with a TLR3 agonist. We demonstrated that stimulation of TLR3 through addition of exogenous dsRNA caused a drastic increase in the level of RIG-I protein. …
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