Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 89 for “"TLR2"”.
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Bats and their endoparasites : characterising pipistrelle infections and toll-like receptor (TLR2 and TLR4) gene variations
… a PCR strategy was developed to isolate TLR4 and TLR2 genes from the pipistrelle bats (n=59). The TLR4 sequences were highly variable at the amino acid level (haplotypes, n=42), and a phylogenetic analysis of the protein sequences showed that they clustered into 7 major groups. Analysis of …
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Toll-like Receptors 2 and 9 Are Important for Innate Immune Cell Activation and Recruitment in Hypersensitivity Pneumonitis
… to neutrophil recruitment. We generated TLR2/9 double knockout (TLR2/9−/− ) mice to determine the extent to which TLRs 2 and 9 cooperate in neutrophil recruitment during HP. During the acute response, TLR2/9−/− mice exposed to SR demonstrated a significant reduction in neutrophil …
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Defining the mechanisms of microbial sensing among members of the toll-like receptor 2 sub-family
… are the most potent microbial agonists for the TLR2 subfamily and this pattern recognition event induces cellular activation leading to host immune responses. TLR2 mediates cellular responses to triacylated and diacylated bacterial lipoproteins by forming heterodimers with either TLR1 or TLR6, …
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Expression and Function of Toll-Like Receptor 2 and 4 in Human Melanocytes
… melanogenesis. First, the mRNA expression of TLR2, TLR4 and their adaptor proteins, CD14 and myeloid differentiation factor-88 (MyD88) was shown by RT-PCR. Protein expression and localization of TLR2, TLR4 and CD14 were detected by western blot, flow cytometry and immunocytochemistry. …
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Pathological mechanisms of the ischemic white matter injury in animal model of lacunar infarction
… responses. There was a significantly increaseof TLR2 in the ET-1 induced ischemic white matter lesion. Increased expression of TLR2 in ischemic white matter lesion was also observed in human sample. Intriguingly, the extent of demyelinating pathology was markedly larger in TLR2 deficient mice …
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HP Turns 17: T helper 17 cell response during hypersensitivity pneumonitis (HP) and factors controlling it
… previous studies in our lab showed that TLR2/9 double knockout (DKO) exposed mice were characterized by a decrease in the percentage of Th17 cells in their lungs compared to WT mice. Consequently, we hypothesized that the decrease in Th17 response is attributed to defect in phagocytosis, …
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건선 피부에서 Toll-like receptors와 antimicrobial peptides의 발현과 혈청 내 비타민 D과의 관계
… and normal controls, the distribution of TLR1, TLR2, TLR4, HBD2 and LL-37 in psoriasis lesion occurs more strongly in the upper epidermis. PP skin showed more expression of TLR1 and less expression of TLR2, HBD3 and VDR than NN skin. PP skin also showed more expression of TLR1 and less …
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THE ROLE OF P24 PROTEINS IN THE ER TO GOLGI TRANSPORT OF TOLL-LIKE RECEPTORS
… Assay (PLA) reveal that TMED7 interacts with TLR2 and TLR4, but not with TLR3. In contrast, TMED2 interacts with TLR2, TLR4 and TLR3. Different TLRs were co-expressed with ER-export deficient TMED7 and TMED2 and their cellular localisation observed using confocal microscopy. These data suggest …
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Effects of Vitamin D on Expression of Toll-like Receptors of Monocytes from Patients with Behcet's Disease
… active BD patients showed higher expression of TLR2, TLR4 with increased proportion of CD16+ cells compared to the control groups. Interestingly the 25-hydroxyvitamin D levels were inversely correlated with the expression of TLR2, TLR4 and clinical indicators. In vitro study, 1,25(OH)2D3 …
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Chlamydia pneumoniae, Toll-like Receptors and Pathogenesis of Atherosclerotic Heart Disease
… elicits foam cell formation predominantly via TLR2 by examining macrophages from TLR2<sup>–/–</sup> mice. TLR2, TLR4 and TLR7 agonists require exogenous LDL for foam cell formation, whereas a TLR3 agonist induces foam cell formation even in the absence of added LDL. TLR3, but not TLR2 and TLR4 …
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Toll-like receptor mediated responses to adsorbed damage-associated molecular patterns on biomaterial surfaces
… cytokine production was strongly attenuated by TLR2 neutralizing antibodies. Work with primary bone marrow-derived macrophages confirmed the similar contribution of TLR2- and MyD88-dependent signalling in pro-inflammatory, anti-inflammatory, and angiogenic cytokine gene expression and production …
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Exploring the Effects of Adjuvant Selection on a Novel Polyvalent Staphylococcus aureus Vaccine
… AdjuPhos. The addition of toll-like receptor 2 (TLR2)-containing agonists enhanced S. aureus clearance, and consequently, further cellular studies were undertaken with a novel TLR2 agonist to identify the protective host response. The splenocyte supernatant of mice immunised with the polySSL-TLR2 …
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An In Vitro Assessment of The Potential for Engineered Nanoparticles to Modulate Innate Immunity
… employed; one stably expressing TLR 2 (HEK293-TLR2) and the other devoid of TLRs (HEK293-WT). A select group of ENPs; silver nanoparticles (75 nm), gold nanorods (48 nm + 4 nm), and carboxylated, and pristine semi-conducting (0.8 nm) single-walled carbon nanotubes (SWNT) was used to assess the …
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ST2 & TLRs: coordination of chemokine-driven immunity
… number of discretely labelled cells from WT- and TLR2-KO- mice into WT mice with an existing inflammation, we were able to show that systemic administration of a TLR2 agonist caused a reduction in the number of transferred WT- but not TLR2-KO- cells migrating into the site inflammation. Consistent …
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The evolution of immune genes in tsetse flies (Glossina) and insights into tsetse-symbiont-trypanosome interactions
… (AttA), Defensin (Def) and Toll-like receptor 2 (TLR2), in relation to symbionts and parasitic interactions. This could in turn lay the foundations for genetic control methods The successful identification of novel attacin orthologues confirmed the previous descriptions of attacin clusters within …
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Die Rolle definierter Subpopulationen humaner peripherer Blutzellen für die Masernvirus-induzierte Immunsuppression und Immunaktivierung
… nicht aber Vakzinestämme humanes und murines TLR2, wahrscheinlich mit CD14 als Korezeptor, und nicht TLR4, aktivieren. Die TLR2 agonistische Eigenschaft konnte dem MV-Wildtyp Hämagglutininprotein (H) zugeordnet werden. Der Austausch einer einzigen Aminosäure im WTF-H, Asparagin zu Tyrosin an …
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Synovial Fibrosis in Osteoarthritis of the Knee: Mechanism of Development and Potential Therapeutic Targets
… the CD44 receptor. Furthermore, rhPRG4 binds to TLR2 and TLR4 and acts as an antagonist to prevent TLR2 and TLR4 activation by bacterial ligands. In this work, we aimed to investigate the role of CD44 receptor and its ligands HA in regulating the activation of macrophages in response to TLR2 …
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The role of adaptor protein Mal/TIRAP in transducing TLR signalling
… first intracellular component of the TLR4 and TLR2 signalling pathways. In the traditional model of signalling, ligand stimulation dimerises TLR4 and TLR2 which then recruits Mal/TIRAP. Mal/TIRAP links the TLRS to the formation of the supra molecular organising centre, the myddosome. The …
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Dietary fatty acids modulate inflammatory cytokine production through activation of MAP kinases
… have shown involvement of toll llke receptor TLR2 and TLR4 in some of these inflammatory diseases shown to be inhibited by PUFA, In order to detemine how PUFA exert their beneficial effects in these diseases it is important to examlne how PUFA modulate the expression and actlvatlon of TLR2 and …
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