Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"TLR1"”.
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TLR1 I602S: trafficking dynamics and roles in resistance to mycobacterial infection
… and adaptive immunity. Toll-like receptor 1 (TLR1), in cooperation with TLR2, is essential to the innate immune sensing of bacterial cell wall components, such as triacylated lipoproteins, lipoglycans and, in particular, many mycobacterial-associated molecules. The other eight TLRs recognize a …
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Defining the mechanisms of microbial sensing among members of the toll-like receptor 2 sub-family
… lipoproteins by forming heterodimers with either TLR1 or TLR6, respectively. Crystal structure analysis revealed that triacylated bacterial lipoproteins coordinately bind TLR1 and TLR2 resulting in a stable ternary complex that drives intracellular signaling. However, the order of complex …
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Molecular Characterization of Microbial Sensing by Members of the Human Toll -Like Receptor 2 Sub-Family
… summary, we have identified specific residues of TLR1 that play an essential role in mediating response to microbial agonists and defined a target region for therapeutic agents.
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건선 피부에서 Toll-like receptors와 antimicrobial peptides의 발현과 혈청 내 비타민 D과의 관계
… and normal controls, the distribution of TLR1, TLR2, TLR4, HBD2 and LL-37 in psoriasis lesion occurs more strongly in the upper epidermis. PP skin showed more expression of TLR1 and less expression of TLR2, HBD3 and VDR than NN skin. PP skin also showed more expression of TLR1 and less …
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Understanding functional mechanisms of genetic susceptibility to mycobacterial infection
… particular, we identified an eQTL located in the TLR10-TLR1-TLR6 gene cluster. In non-infected macrophages, a group of polymorphisms in this region was associated in cis with the level of expression of TLR1, but not of the other two TLR genes. In M. tb-infected macrophages the same polymorphisms …
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The Regulation Of Myeloid Inflammatory Responses By Runx1: Roles In Normal And Malignant Hematopoiesis
… we describe a novel role for RUNX1 in regulating TLR1/2 and TLR4 signaling and inflammatory cytokine production by neutrophils. Hematopoietic-specific RUNX1 loss increased the production of pro-inflammatory mediators, including tumor necrosis factor α (TNF-α), by bone marrow neutrophils in …
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The effects of hyaluronic acid and exercise on equine skeletal muscle
… and cytokine production (Il17RA, OSCAR, LYL1, TLR1, TLR2, TLR8, TLR10) but did not irreversibly down regulate these genes with the addition of exercise. Exercise as a stressor did cause an acute inflammatory response in muscle which was seen through global expression of macrophage and …
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Deciphering the relationship among nutrition, host and microbe
… cells, and intestinal epithelial cells. Using TLR1 and TLR6 knockout mice, these studies aim to understand how disruption in host recognition of the microbiota can exacerbate disease. In Chapter 5, aberrant TLR1 signaling led to increased mucosal-adherent microbes and defective mucosal …
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Vip And Host Immunity
… siRNA experiments indicated that VIP regulated TLR1, TRAF6 and ST2 in a cAMP dependent manner, but Chuk, IRAK1, 2, TLR4, 9 and SIGIRR were cAMP independent. In vitro, VIP down-regulated pro-inflammatory, but increased anti-inflamamtory TLRs in macrophages and Langerhans (XS52) cells. Exogenous …
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Evolutionary analysis of Suidae TLR signaling pathway
… end, coding sequences of bacterial sensing TLR (TLR1, TLR2 and TLR6) and viral sensing TLR (TLR3, TLR7 and TLR8) were retrieved from resequencing libraries of one animal representing each of the following members of the family Suidae: Sus scrofa from Europe, Sus scrofa from Asia, Potamochoerus …
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Role of Toll-like receptors in airway inflammation
… TLR family presently comprises ten members (TLR1-TLR10), each with distinct properties. Although the TLRs protect the host from infection, they have become increasingly implicated in the pathogenesis of various inflammatory diseases, including asthma and allergy. The aim of this thesis was to …
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CANNABINOID RECEPTOR 2 AGONIST REDUCES IMMUNE CELL MIGRATION IN NEUROINFLAMMATION VIA INHIBITION OF MATRIX METALLOPROTEINASE-9
… in the expression of toll-like receptors (TLR1, TLR4, TLR6, and TLR7), which correlated with a decreased number of immunoreactive microglia. Interestingly, at seven days post injury, CB2R agonist-treated injured cords showed a significant reduction in both hematopoietic and myeloid cell …