Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"TLR-4."”.
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LPS, A TLR-4 AGONIST AND VIPER A TLR-4 INHIBITOR UPREGULATE PHAGOCYTOSIS OF ZYMOSAN IN BV2 CELLS
… we investigated the potential impact of TLR-4' The LPS receptor' on zymosan phagocytosis by treating BV2 cells with a TLR-4 viral inhibitor (VIPER) or a TLR-4 polyclonal antibody showing their antagonistic effects on phagocytosis. Finally, we demonstrated that VIPER has the unique ability …
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Investigating TLR-4 signalling in response to protein ligands
Toll-like receptor (TLR)-4 is a pattern recognition receptor (PRR) that recognises the pathogen-associated molecular pattern (PAMP) lipopolysaccharide (LPS) produced by Gram-negative bacteria. LPS binds to Myeloid differentiation 2 (MD-2)/TLR-4 heterodimers, driving their dimerisation and inducing …
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Quantitative analysis of TLR-4-mediated cell responses in murine macrophages
TLR-4 is essential in host defense against bacterial infection. By recognition of specific pathogen-associated molecular patterns such as lipopolysaccharide (LPS), TLR-4 can in tandem initiate a pair of downstream signaling pathways to regulate cytokine/chemokine release, endotoxin tolerance and …
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The role of Toll-like receptor 4 (TLR-4) in wine-induced cardioprotection
… on the activation of Toll-like receptor 4 (TLR-4) to activate TNF-α/STAT-3.
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Design, synthesis, and evaluation of release kinetics of novel LFA-1 and TLR-4 inhibitor prodrugs for localized immunomodulation.
… of release kinetics of novel prodrugs of TLR-4 antagonist TAK-242, which inhibits the early stages of innate immune inflammation, the development and biological evaluation of novel LFA-1 inhibitor compounds, which inhibit early T-cell trafficking of the adaptive immune system, and the …
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Protective Mechanism of Epigallocatechin-3-gallate against Helicobacter pylori- induced Gastric Epithelial Cytotoxicity via Blockage of TLR-4 Signaling
… on H. pylori-induced the toll-like receptors 4 (TLR-4) signaling, RT-PCR and western blot analysis corresponding to glycosylated TLR-4 was done. LOX metabolites were measured with RP-HPLC. EGCG pretreatment effectively rescued gastric mucosal cells from the H. pylori-induced apoptotic cell death …
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A Novel Mouse Model of Asthma Induced by Cockroach
… the role of endotoxin and toll like receptor-4 (TLR-4) for the induction of asthma in mouse model. METHODS: CR allergen was delivered intranasally to BALB/C mouse, TLR-4 mutant (C3H/HeJ) or wild type (C3H/HeN) mouse without any adjuvant. Asthma was induced by CR, CR with endotoxin added (10,000 …
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The recognition of lipopolysaccharides present in Gram-negative bacteria by receptors of the immune system
… the co-receptor known as Toll-like receptor 4 (TLR-4), which in the presence of an accessory receptor known as myeloid differentiation 2 (MD-2) triggers immunity against gram-negative bacteria. Experiments were designed to investigate the effect of purified exogenous LPS on the expression of …
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The effect of fasting on anti-inflammatory mediators, IL-1RA and IL-1R2, and their role in resistance to sickness behaviors in mice
… IL-1RA up-regulation are independent of IL-1, TLR-4, IL-4 and glucocordicoid signaling. Here we also demonstrate that free fatty acids (FFA) are increased in the plasma as a consequence of fasting. Using palmitic acid injection to mimic fastings FFA increase, we elucidated a novel mechanism by …
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Investigation into the role of HMGb1 in relation to myofibroblasts and cancer cells exposed to various conditions
… immunoneutralising antibodies to HMGb1, RAGE and TLR-4, along with specific inhibitors of PI3K and MEK1/2. In addition, MMP-2 and MMP-9 two major degraders of basement membrane were investigated for their involvement in CCD18 myofibroblasts migration and invasion in matrigel membrane invasion …
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Modulation of macrophage and epithelial cell immune defences by probiotic bacteria: immune stimulation versus suppression
… were quanti-fied by ELISA and RT-PCR, whereas TLR-2, TLR-4, Tollip, SOCS3, STAT3 and TRAIL by RT-PCR. This study revealed that, first, live C28 and MS13 stimulated the proinflammatory cytokine by M2-like macrophages as well as the anti-inflammatory cytokine in a homeostatic status; whereas in …
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Development of a Novel Vaccine Adjuvant and Delivery System for Cancer and Influenza
… efficient in activating innate immune system via TLR-4. Significantly higher Th1 (IgG-2a antibody titers, IFN-γ, and IL-2 cytokines) and Th2 (IgG-1 antibody titers, IL-4 and IL-10 cytokines) immune responses were generated in mice immunized with ova loaded InAc microparticles as compared to …
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The role of elastase as an inflammatory stimulus in chronic obstructive pulmonary disease
… receptor (PAR)-2 and Toll-like receptor (TLR)-4. Although elastase stimulation does not appear to alter the gross amount of these receptors present in the parenchyma, we have found that those patients with mild to moderate COPD tend to have greater levels of both PAR-2 and TLR-4. We have …
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The ability of TLR agonists to upregulate Brucella abortus strain RB51 mediated protection in a murine respiratory model
… Protection against Brucella is mediated through TLRs 2, 4 and 9. The addition of TLR 2 or TLR 4 and a trend with TLR9 agonists with intranasal RB51 vaccination significantly increased bacterial clearance in the lung after strain 2308 challenge. Therefore, we hypothesized that combining TLR …
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Development of vaccines against allergic asthma using products derived from intracellular bacteria or helminths
… Wirkung von lebendem BCG unabhängig vom IL-10, TLR-2, TLR-4 oder MyD88 vermittelten Signalweg. Wurden Mäuse, die mit den verschiedenen Adjuvantien zusammen mit OVA/alum geimpft wurden, einer zweiten Runde OVA/alum Sensibilisierung unterzogen, so konnten nur lebende und hk-BCG die Entwicklung der …
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The Diversity of TLR4-triggered Responses in Mouse Microglia
… verwenden Mikroglia Toll-like Rezeptoren (TLRs), welche sowohl exogene als auch endogene "Gefahren" erkennen. Die Stimulation der mikroglialen TLRs resultiert in einer angeborenen Immunreaktion, welche den Schutz des ZNS sowie die Unterstützung von Reparaturprozessen an geschädigten Geweben …
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Aging Dendritic Cell Function and Effects on T Helper Cell Differentiation
… male mice stimulated with Toll-like receptor (TLR) agonists, alone or in combination, secrete increased IL-23, a cytokine involved in the Th17 cytokine axis. IL-12, a cytokine involved in the Th1 axis does not change. This shift in cytokine secretion occurs between 6 and 12 months of age and is …
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Benefits of Quercetin on Metabolic and Inflammatory Biomarkers in High Fat Diet Induced Obesity: A Dose Response Study
… of inflammatory mediators (MCP-1, TNF-├â┬í, and TLR-4). This data confirm the ability of quercetin to reduce metabolic and inflammatory biomarkers in a high fat diet induced obesity model. These findings may lead to the development of a safe and effective dose of a natural dietary supplement that …
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Effect of phosphorylcholine-based small molecule analogues of the immunomodulatory nematode product ES-62 on mast cell function
… of human mast cells by forming a complex with TLR-4 and subsequently sequestering PKC-α away from the high affinity receptor for IgE, FcεRI. In this work, PKC-α was found to be critical for mast cell degranulation and its degradation provided a mechanism for the ES-62-mediated disruption of key …
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Interaktion von inflammatorisch aktivierten retinalen Pigmentepithelzellen mit retinaler Mikroglia und neuronalen Zellen
… Konzentrationen zum Einsatz: Pam2CSK4 (Pam; TLR-2), Polyinosin-Polycytidylsäure (Poly I:C; TLR-3) und Lipopolysaccharid (LPS; TLR-4). Die Zellviabilität wurde mittels MTT-Assay bestimmt. Die Zytokinsekretion wurde per ELISA und die Expression mittels Real-Time PCR analysiert. Die Agonisten …
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