Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"TLR 7/8 agonists"”.
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Combination of STING and TLR 7/8 agonists as vaccine adjuvants for cancer immunotherapy
… of immunoadjuvants such as toll-like receptor (TLR) agonists, exosomes, and metallic immunoadjuvants have been studied for their immunological effects. However, the clinical use of immunoadjuvants is limited by transient responses and various side-effects. Therefore, there is a need for …
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Aging Dendritic Cell Function and Effects on T Helper Cell Differentiation
… male mice stimulated with Toll-like receptor (TLR) agonists, alone or in combination, secrete increased IL-23, a cytokine involved in the Th17 cytokine axis. IL-12, a cytokine involved in the Th1 axis does not change. This shift in cytokine secretion occurs between 6 and 12 months of age and is …
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Engineering kinetics of immunotherapies and vaccines
… imidazoquinolines (IMDs), small molecule agonists of Toll like receptor (TLR)-7 and/or TLR-8, are of great interest as potential anti-cancer therapeutics due to their ability to activate innate immune cells. Nevertheless, safe and effective systemic administration of these compounds in the …