Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 249 for “"TLR"”.
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LPS, A TLR-4 AGONIST AND VIPER A TLR-4 INHIBITOR UPREGULATE PHAGOCYTOSIS OF ZYMOSAN IN BV2 CELLS
… we investigated the potential impact of TLR-4' The LPS receptor' on zymosan phagocytosis by treating BV2 cells with a TLR-4 viral inhibitor (VIPER) or a TLR-4 polyclonal antibody showing their antagonistic effects on phagocytosis. Finally, we demonstrated that VIPER has the unique ability …
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Evolutionary analysis of Suidae TLR signaling pathway
… defense against pathogens. Toll-like receptors (TLRs) are the best characterized pathogen recognition receptors (PRRs) of the innate immune system. TLRs detect distinct pathogen associated molecules and engage downstream intracellular signaling cascades eventually leading to an innate immune …
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Investigating TLR-4 signalling in response to protein ligands
Toll-like receptor (TLR)-4 is a pattern recognition receptor (PRR) that recognises the pathogen-associated molecular pattern (PAMP) lipopolysaccharide (LPS) produced by Gram-negative bacteria. LPS binds to Myeloid differentiation 2 (MD-2)/TLR-4 heterodimers, driving their dimerisation and inducing …
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Regulation of inflammatory TLR signalling by the BCAP adaptor
BCAP is a PI3K adaptor protein in TLR, BCR and IL-1R and TCR signalling. In TLR signalling, BCAP acts as a negative regulator of inflammatory signalling. Regulation of TLR signalling is essential as overstimulation can cause excessive and pathological inflammation, which leads to serious illnesses …
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The role of BCAP in regulating the TLR signalling pathway
Toll-like receptors (TLRs) are crucial sensors in innate immunity against microbial infections. Their pro-inflammatory signal transduction typically involves the oligomerisation of downstream TIR-domain-containing adaptors MAL and MYD88. BCAP (B-cell adapter for PI3K) was identified as a negative …
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The role of adaptor protein Mal/TIRAP in transducing TLR signalling
Toll-like receptor 4 (TLR4) plays an essential role in the innate immune system, protecting the body from gram-negative bacteria. However, while TLR4 activation is essential for host defence, it can also drive harmful inflammatory responses, contributing to conditions such as sepsis. Understanding …
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Quantitative analysis of TLR-4-mediated cell responses in murine macrophages
TLR-4 is essential in host defense against bacterial infection. By recognition of specific pathogen-associated molecular patterns such as lipopolysaccharide (LPS), TLR-4 can in tandem initiate a pair of downstream signaling pathways to regulate cytokine/chemokine release, endotoxin tolerance and …
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CD180/RP105 Toll-like Receptor (TLR) mediated signalling in Chronic Lymphocytic Leukaemia
… of receptors, including Toll-like receptors (TLR). CD180/RP105 is a membrane-associated orphan receptor that belongs to the TLR family, is expressed by professional antigen-presenting cells, and drives normal B-cell activation and proliferation. We have previously shown that approximately 60% …
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THE MECHANISM OF JUNB TRANSCRIPTIONAL REGULATION UNDER TLR ACTIVATION IN MOUSE MACROPHAGES
Toll-like receptor (TLR) - pathway crosstalk caused by multiple PAMPs induces proinflammatory cytokine synergy in macrophages. Several potential synergistic factors including JunB have been found. But the mechanisms of junb regulation in macrophages are unclear. In this thesis work, we showed that …
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The role of Toll-like receptor 4 (TLR-4) in wine-induced cardioprotection
… on the activation of Toll-like receptor 4 (TLR-4) to activate TNF-α/STAT-3.
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Combination of STING and TLR 7/8 agonists as vaccine adjuvants for cancer immunotherapy
… of immunoadjuvants such as toll-like receptor (TLR) agonists, exosomes, and metallic immunoadjuvants have been studied for their immunological effects. However, the clinical use of immunoadjuvants is limited by transient responses and various side-effects. Therefore, there is a need for …
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Disassembly of electron transport chain complexes drives macrophage TLR responses by reprogramming metabolism and translation
… of macrophages through Toll-like receptors (TLR) disrupts the assembly of mitochondrial electron transfer chain (ETC) complexes I-V, leading to the metabolic switch by inhibiting OxPhos and activating HIF-1[alpha]-dependent glycolysis. Disassembly of ETC complexes influences the global …
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Mycobacterium tuberculosis and trypanosoma brucei as models for the TLR-dependent activation of the innate immune system
Includes bibliographical references.
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Solid phase peptide synthesis and TLR-5 activity analysis of pertide fragments from the Salmonella muenchen flagellin protein
… receptor of interest. The Toll-Like Receptor-5 (TLR-5) is an attractive target for pharmaceutical modulation because it initiates an innate immune response. A TLR-5 agonist or antagonist could help remedy a variety of disorders. Flagellin, the primary component of bacterial flagella, is the only …
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The ability of TLR agonists to upregulate Brucella abortus strain RB51 mediated protection in a murine respiratory model
… Protection against Brucella is mediated through TLRs 2, 4 and 9. The addition of TLR 2 or TLR 4 and a trend with TLR9 agonists with intranasal RB51 vaccination significantly increased bacterial clearance in the lung after strain 2308 challenge. Therefore, we hypothesized that combining TLR …
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Design, synthesis, and evaluation of release kinetics of novel LFA-1 and TLR-4 inhibitor prodrugs for localized immunomodulation.
… of release kinetics of novel prodrugs of TLR-4 antagonist TAK-242, which inhibits the early stages of innate immune inflammation, the development and biological evaluation of novel LFA-1 inhibitor compounds, which inhibit early T-cell trafficking of the adaptive immune system, and the …
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Protective Mechanism of Epigallocatechin-3-gallate against Helicobacter pylori- induced Gastric Epithelial Cytotoxicity via Blockage of TLR-4 Signaling
… on H. pylori-induced the toll-like receptors 4 (TLR-4) signaling, RT-PCR and western blot analysis corresponding to glycosylated TLR-4 was done. LOX metabolites were measured with RP-HPLC. EGCG pretreatment effectively rescued gastric mucosal cells from the H. pylori-induced apoptotic cell death …
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Functional interaction between CD180 Toll-like receptor (TLR) and B cell receptor (BCR) in the biology of Chronic Lymphocytic Leukaemia (CLL)
… and receptors, including Toll-like receptors (TLR). The role of the microenvironment in the development and progression of CLL is currently of major interest. Pathogen- and damage-associated molecular patterns (PAMPs and DAMPs, respectively) represent exogenous and endogenous microenvironmental …
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