Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"TLE3"”.
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The TAZ Protein Interactome in Striated Muscle
… the TAZ interaction with the Wnt co-repressor TLE3 in myogenic cells. In myogenic cells, TAZ and TLE3 interact and co-localize within the nucleus. Functionally, TAZ and TLE3 repress β-catenin activation, as indicated by the Wnt-responsive TOP FLASH reporter gene system. Depletion of TAZ reduced …
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Detection of AR gene rearrangements and regulation of AR variant-driven prostate cancer models
… sample. Finally, we characterized the role of TLE3 in AR-V-driven prostate cancer models. We found that TLE3, a transcriptional co-repressor, supports anchorage- independent growth and restricts migration in prostate cancer cell lines that express AR-Vs. Mechanistically, we found that TLE3 …
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The role of FOXK transcription factors in Wnt signal transduction
… as well as the transcriptional repressor Groucho/TLE3. While much is known about the basic interactions within the enhanceosome, it remains elusive how the enhanceosome accesses native chromatin and is established during development. Furthermore, it is controversial how transcriptional inhibition …