Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"TKI"”.
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T-cell activity in CML patients after TKI discontinuation
Tutkielman aiheena oli kroonista myeloista leukemiaa sairastavien potilaiden T-solujen aktiivisuus ja sytokiinituotanto. Potilasmateriaalina oli ns. STOP-tutkimuksen potilaat, joita on seurattu Hematologisessa tutkimusyksikössä vuodesta 2006. STOP- tutkimuksen yhtenä kiinnostuskohteena oli …
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A Role For Lipid Rafts In Egfr Tki Resistance In Breast Cancer
… small molecule tyrosine kinase inhibitors (TKIs). Specifically, we have shown that EGFR localizes to discrete membrane microdomains (lipid rafts) in cell lines that are resistant to EGFR TKI-induced growth inhibition. Depletion of lipid rafts via cholesterol reduction results in sensitivity …
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Hubungan kepuasan hidup dengan kepuasan kerja pada mantan Tenaga Kerja Indonesia (TKI) di Desa Arjowilangun
… hidup pada mantan Tenaga Kerja Indonesia (TKI) yang mana banyak sekali kasus kekerasan atau tidak menyenangkan yang dialami oleh para Tenaga Kerja Indonesia (TKI), dan penelitin ini dilakukan di desa Arjowilangun yang mempunyai gejala sosial yang berbeda dengan desa-desa yang berada di …
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Uncovering Molecular Targets to Overcome Immunosuppression In Non-Small Cell Lung Cancer With Acquired Tki Resistance
… receptor (EGFR) tyrosine kinase inhibitors (TKIs) or monoclonal antibodies targeting vascular endothelial growth factor (VEGF/R), can effectively inhibit upregulated signaling pathways driving tumorigenesis in NSCLC and many other cancers. Unfortunately, however, resistance to such targeted …
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Kebermaknaan hidup istri yang di tinggal suami sebagai TKI: Studi kasus di Desa Ngaglik Kecamatan Palang Kabupaten Tuban
… hidup istri yang di tinggal suami sebagai TKI di Desa Ngaglik Kec. Palang Kab. Tuban yakni untuk mengetahui bagaimana konsep kebermaknaan hidup bagi istri yang di tinggal suami sebagai TKI dan untuk mengetahui faktor- faktor kebermaknaan hidup apa saja yang mempengaruhi seorang istri yang …
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The practice of sirri marriage in Malaysia: Case study of Indonesian migrant workers (TKI) in Selangor state of Malaysia
… perkawinan sirri. Seperti kasus buruh migran (TKI) yang bekerja di Malaysia, hampir 90 % TKI yang berada di wilayah Serawak melakukan perkawinan sirri. Kajian ini difokuskan pada pernikahan sirri TKI di negara bagian Malaysia yang meliputi; Selangor, Kuala Lumpur, Pulau Pinang,dan Kuantan …
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Eskalasi perceraian di lingkungan Tenaga Kerja Indonesia (TKI) masyarakat Pulau Kangean Kabupaten Sumenep: Studi kasus di Pengadilan Agama Kangean
… eskalasi perceraian dalam rumah tangga TKI. Kemudian apakah ada pengaruh banyaknya masyarakat Pulau Kangean yang menjadi TKI dengan eskalasi perceraian di Pulau Kangean. Penelitian ini termasuk studi kasus (Case Study) yang bertujuan mengetahui adanya keterkaitan anggota keluarga Tenaga …
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INTERPLAY BETWEEN MDM2 AND TFAM REGULATES OXIDATIVE PHOSPHORYLATION IN DRUG-RESISTANT ONCOGENE-ADDICTED CANCERS
Tyrosine kinase inhibitors (TKI) remain the first-line treatment for most oncogene-addicted cancers. However, prolonged exposure to TKI could lead to development of resistance. There is mounting evidence of OXPHOS dependency as a mechanism of TKI resistance, but the cause of this metabolic switch …
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Proteasome inhibition in chronic myeloid leukaemia
CML is treated effectively with TKI, however two key problems remain - the insensitivity of CM HSC to TKI and the emergence of TKI-resistant BCR-ABL mutations. BCR-ABL activity is associated with increased proteasome activity and PI are cytotoxic against CML cell lines. We demonstrate that …
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Kebutuhan seksual sebagai penyebab utama tingginya angka perceraian Tenaga Kerja Indonesia (TKI): Studi kasus di Desa Songgon Kecamatan Songgon Kabupaten Banyuwangi
… satu pasangan (baik suami atau istri) menjadi TKI di luar negeri dan kondisi tidak terpenuhinya kebutuhan biologis (seksual) menjadi alasan utamanya. Jika salah satu pasangan menjadi TKI secara otomatis frekuensi perjumpaan antara suami dan istri sangat jarang dan menjadikan tidak terpenuhinya …
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Defining The Role of Egfr Acetylation In Cellular Processes: Clinical Implications
… by combining EGFR tyrosine kinase inhibitors (TKI) with other anti-cancer agents, we observed that suberoylanilide hydroxamic acid (SAHA, a deacetylase inhibitor) enhanced TKI-induced cancer cell death, which further led us to question whether SAHA-mediated sensitization to TKI was associated …
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Novel treatment strategy for ALK-positive Anaplastic Large Cell Lymphoma
… Single-agent use of tyrosine kinase inhibitors (TKI) to inhibit ALK is a conventional second-line treatment and has been trialled for upfront use in combination with the ALCL99 therapeutic backbone. However, an extended duration of treatment is required as cessation of therapy can lead to rapid …
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Renal and kardiovaskulär adverse events after anti-VEGF-treatment
… und möglicher Nebenwirkungen nach TKI-Behandlung.
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TARGETING THE DNA DAMAGE RESPONSE PATHWAY FOR THE TREATMENT OF AGGRESSIVE THYROID CANCERS, IN VITRO STUDIES
… line treatments and tyrosine kinase inhibitors (TKIs). Though, part of them as well as Poorly Differentiated and Anaplastic TC are particularly aggressive and refractory both to first-line and TKI treatments, such as Lenvatinib (LENV). In other aggressive tumours (NSCLC, HCC, CML), TKI resistance …
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Tumor cell-intrinsic signals promoting tolerance and adaptation to oncogenic kinase inhibition
… (TKs). Using commonly prescribed TK inhibitors (TKIs), I show that TK genetic status generally predicts whether or not a cell line will show any response to genotype-matched TKI (GM-TKI), but is insufficient to predict drug tolerance, the ability of a cell line to sustain proliferation under …
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Expression and function of drug transporters in primitive CML cells
… mesylate (IM), a tyrosine kinase inhibitor (TKI) that competes with ATP to block ABL kinase activity, which in turn prevents tyrosine phosphorylation of downstream molecules and selectively induces apoptosis of BCR-ABL cells. However, despite excellent cytogenetic responses, only a minority …
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GENERATION OF SYNTHETIC ANTIBODIES AS POTENTIAL THERAPEUTICS TO BLOCK IL3–MEDIATED INNATE IMATINIB RESISTANCE IN CHRONIC MEYLOID LEUKEMIA
… leukemia (CML). Tyrosine kinase inhibitor (TKI), imatinib, is the standard therapy for CML. Although many patients respond to the conventional TKI chemotherapy, the majority relapse upon withdrawal of treatment (Ross et al., 2013) implicating the inability of TKIs in eradication of leukemic …
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Flourescent Biosensor-Based, Cdc42 Activity Imaging For Understanding the Regulation of Epidermal Growth Receptor (EGFR) Signalling in Head and Neck Cancer
… Cell Lines after EGFR tyrosine kinase inhibitor (TKI) treatment, using the FRET biosensor Raichu-Cdc42. I have demonstrated that conversely, Raichu-Cdc42, and consequently endogenous Cdc42 activity increases significantly following EGFR TKI treatment. Further investigation revealed that the …
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Defining CP-CML patient subsets associated with poor imatinib uptake and response.
The introduction of tyrosine kinase inhibitor (TKI) therapy, specifically imatinib, has dramatically improved the treatment outcome for the majority of chronic phase chronic myeloid leukaemia (CP-CML) patients. Although most patients will achieve excellent clinical (haematological, cytogenetic and …
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Immunological Characterization of Membrane Skeletal Proteins in "Tetrahymena pyriformis" GL
… Low salt extraction of Triton-potassium iodide (TKI) cortical residues is an efficient means by which three membrane skeletal proteins (band A (235 kDa), band C (125 kDa), and a 23 kDa protein) can be isolated. Previous immunofluorescence studies have localized bands A and C in the cell cortex …
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