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Showing 1 to 11 of 11 for “"TIS21"”.
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TIS21 inhibits cell migration and invasion
TIS21/BTG2/PC3 is tumor suppressor gene and frequently downregulated in cancer tissue. In human tissue, decreased BTG2 is correlated with cancer cell metastasis, suggesting that suppression of BTG2 has a critical role in cancer cell migration and invasion. When we overexpressed TIS21 in A549 cells, …
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TIS21 inhibits cell migration by downregulating expression of matrix metalloproteinases
… phorbol acetate-inducible sequence 21 (TIS21) is the mouse homolog of rat pheochromocytoma cell 3 (PC3) and human B-cell translocation gene 2 (BTG2). TIS21 regulates cell cycle progression and proneural genes expression by acting as a transcription coregulator that enhances or inhibits …
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Effect of TIS21 on DNA Damage Repair Induced by Etoposide
TIS21/BTG2/PC3 (12-O-tetradecanoyl phorbol-13-acetate-inducible sequence 21) has been known as a p53 target gene and functions as a tumor suppressor in carcinogenesis of thymus, prostate, kidney, and liver. Although it has been known that the expression of TIS21/BTG2/PC3 was induced during …
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Induction of Cellular Induction Senescence by BTG2_(TIS21/PC3) Gene in Huh7 Hepatocellular carcinoma Cells
TIS21^(BTG2/PC3) regulates G1-S and G2-M progressions of cell division cycle through the inhibition of G1 phase cyclin biosynthesis, and the delayed degradations of cycin B1 and cyclin A, respectively. Therefore, we earlier suggested that TIS21 might play a role as a pan-cell cycle regulator and an …
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Regulation of Senescence Phenotypes by TIS21 gene in Huh7 Human Liver Cancer Cells
… 으로서도 작용되어질 수 있다고 알려져 있다. 본 연구에서 사용한 유전자인 TIS21은 TPA에 의해 유도되어지는 21번째 sequences로서 anti-proliferative family에 속하는 단백질이다. 이 유전자는 mouse에서는 TIS21(TPA inducible sequences 21), human에서는 BTG2(B-cell translocation gene-2), rat에서는 PC3(pheocromocytoma clone-3)로 존재하는 동등 유전자이다. TIS21는 세포내의 전사 보조 인자, …
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TIS21 shifts p53-induced response of EJ bladder carcinoma cells from senescence to apoptosis
… to DNA damage signals both in human and animals. TIS21BTG2/PC3 has been known as a p53 target gene and functions as a tumor suppressor in carcinogenesis of thymus, prostate, kidney, and liver. Bladder carcinoma EJ cells contain both oncogenic H-ras and non-functional p53 tumor suppressor due to …
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Analyse Neurone-generierender Zellteilungen im Neuroepithel der Maus
… unter Kontrolle regulatorischer Sequenzen des TIS21-Gens wurden spezifisch Neurone-generierende Neuroepithelzellen markiert, um (i) die Symmetrie der Neurone-generierenden Zellteilung videomikroskopisch zu untersuchen und (ii) eine differenzielle Analyse der Zellbiologie (z.B. Verteilung …
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Role of BTG2/TIS21/PC3 in differentiation of myeloid leukemia cells and its regulation under stress conditions
Mouse TIS21 (12-O-tetradecanoyl phorbol-13-acetate inducible sequence 21), an ortholog of human BTG2 (B-cell translocation gene 2) and rat PC3, is a tumor suppressor that belongs to antiproliferative gene family, and is implicated in a variety of biological processes. Deregulation of c-Myc …
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Regulatio of actin cytoskeleton by TIS21 vi downregulating reactive oxygen species (ROS) in the doxorubicin-induced premature senescenc
… induced senescence phenotypes. However, TIS21 over expression reduced the phenotypes characterized by the morphological change, SA-β-galstaining, F-actin re-distribution and ROS generations after doxorubicin treatment. The effect of TIS21 on the doxorubicin induced senescence phenotypes …
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Novel in vivo imaging approaches to study embryonic and adult neurogenesis in the mouse
… of BPs. We first validated the use of the Tis21-GFP knock in mouse line, previously generated in our laboratory. We found that the totality of neurogenic progenitors is marked by the expression of a nuclear GFP. We calculated the abundance of BPs overtime since the onset of neurogenesis …