Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"TIRAP"”.
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The role of adaptor protein Mal/TIRAP in transducing TLR signalling
… responses and developing targeted therapies. Mal/TIRAP is an adaptor protein and the first intracellular component of the TLR4 and TLR2 signalling pathways. In the traditional model of signalling, ligand stimulation dimerises TLR4 and TLR2 which then recruits Mal/TIRAP. Mal/TIRAP links the TLRS to …
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Structural basis of membrane targeting and regulation of the innate immunity adaptor TIRAP by its phosphoinositide-binding motif
… being the TIR domain-containing adaptor protein (TIRAP). TIRAP contains a TIR domain, which associates with TLRs and other adaptor proteins; and a N-terminal phosphoinositide-binding motif (PBM) that mediates the membrane recruitment of TIRAP. Upon ligand activation, TLRs are recruited to the …
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Investigating TLR-4 signalling in response to protein ligands
… (Mal)/TIR domain-containing adaptor protein (TIRAP) then binds to the TIR domains of TLR-4 and acts as a bridge for MyD88 which goes on to form the myddosome, a large protein complex of six to eight MyD88 molecules and four Interleukin-1 receptor- associated kinase (IRAK) 4 and four IRAK1/2 …
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Combining PEAK (Promoting the Emergence of Advanced Knowledge) with Other Teaching Methodologies with Children with and without Learning Delays
… the interactive computerised teaching program, TIRAP. Study 2 successfully taught 5 PEAK targets to preschool children (n=3) with speech and language delay and combined PEAK targets with the Rapid Automatic Naming (RAN; Denckla & Rudel, 1976b) for fluency training. Pre and post assessments, …
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Immunomodulatory effects exerted by Lactobacillus salivarius strains on innate immune cells
… strains were found to be the adapter molecules TIRAP and TRIF. Understanding negative regulation of TLR signalling may pave the way for the development of novel therapeutics to limit inflammation in multiple diseases.
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B-Cell Adapter for Phosphoinositide 3-Kinase Is a Signaling Adapter in the Toll-Like Receptor/Interleukin-1 Receptor Superfamily
… 1 receptor domain containing adapter protein (TIRAP). Importantly, BCAP plays an obligate role in linking TLRs to activation of phosphoinositide 3-kinase (PI3K) through recruitment of PI3K to the signaling complex and relief of inhibitory influences on PI3K activity. Importantly, BCAP …
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Characterizing the Innate Immune Response of Human Airway Cells to the Unique Fungal Allergen Alt a 1
… and the downstream adaptor proteins MyD88 and TIRAP. We also found in our studies that Alt a 1 rapidly enters bronchial epithelial cells. Furthermore, our data suggests that endocytosis of Alt a 1 may be partially dependent upon interaction with phosphatidyl-inositol-3-phosphate (PI-3-P).