Global ETD Search
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Showing 1 to 4 of 4 for “"TIN2"”.
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Further Insight into the Two Functions of Telomeres: Determining the Role of Tankyrase1 in Telomere Length Regulation and Tin2 in Telomere Protection
… telomere length in telomerase positive cells. TIN2 interacts with the double-stranded telomeric DNA-binding proteins TRF1 and TRF2 independently or simultaneously, acting as a bridge linking TRF1 and TRF2 to TPP1 and POT1, the single-stranded telomeric DNA-binding protein. To gain further …
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Biochemical and structural studies of human telomerase regulation
… of the CST complex in conjunction with TPP1-POT1-TIN2 and telomerase. As presented in Chapter 5, a newly-observed conformation of CST, together with the pull-down experiments, sheds light on CST interaction with shelterin components. Furthermore, preliminary data on the ternary …
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A Novel Phosphorylation Site in the Telomeric Protein TRF2 is Regulated by the ATR Kinase and Plays a Role in Relieving Replication Stress at the Telomere
… 368 weakens the interaction between TRF2 and TIN2, suggesting that phosphorylation of TRF2 on S368 may relieve replication stress at the telomere by modifying the conformation of shelterin to allow the replication fork to more easily pass.</p>
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Mechanisms of Telomere End Protection by TRF2
… The six subunits of shelterin, TRF1, TRF2, TIN2, TPP1, POT1, and Rap1, each have distinct roles in telomere homeostasis. These include telomere length regulation and preventing telomeres from activating various DNA damage response (DDR) signaling and double-strand break repair pathways. The …