Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"TIMP3"”.
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The Role of TIMP3 in Models of Inflammation and Immunity
… tissue inhibitor of metalloproteinase 3 (TIMP3) has the potential to down-regulate many of these activities. We explore the role of TIMP3 in the regulation of inflammation, revealing that loss of TIMP3 leads to a more rapid increase of soluble TNF, higher levels of soluble TNF receptors …
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FOXO3a in Vascular Smooth Muscle Cell Apoptosis
… and use these cells to validate MMP-13 and TIMP3 as new FOXO3a target genes. Also, we sought to determine the mechanisms of FOXO3aA3ERTM-mediated VSMC apoptosis, particularly regarding MMP-13 and TIMP3, potential MMP-13 substrates in the extracellular matrix and the precise apoptotic …
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Involvement of MicroRNAs in the Regulation of Porcine Follicle Maturation
… most abundant ovarian microRNAs, miR-21, targets TIMP3 in cumulus cells and influences the cumulus cells matrix remodeling via TIMP3-ADAMTS1-VERSICAN cascade. To conclude, our findings suggest a mechanism of post-transcriptional regulation by key microRNAs in the mammalian ovary. Our work supports …
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Clinical importance of microsatellite instability and promoter methylation of DNA in colorectal cancer // Клинично значение на микросателитната нестабилност и промоторното метилиране на ДНК при колоректален карцином
… на промоторното метилиране на гените hMLH, pie, TIMP3 и TPEF/ НРР1 чрез пиросеквениране. Според резултатите в 77 процента от случаите КРК е спорадичен, в 22 процента -фамилен и в 1 процента - наследствен. Честотата на МСН е 15 процента , a hMLHl, pie, TIMP3 и TPEF/HPP1 са метилирани съответно в …
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Genetics of age-related macular degeneration and Stargardt disease in South African populations
… compared to controls, two of which (rs9621622 in TIMP3 and rs17110714 in ABCA4 ), were statistically significant ( p values of 9.95 x 10 - 4 and 1.04 x 10 - 2 , respectively). Discussion and Conclusion: Although a number of variants were identified in the coding region of three haplotype - …
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Untersuchungen über Veränderungen des Epigenoms bei der chronischen lymphatischen Leukämie
… p16 (6.3%), RARbeta2 (3.1%), SFRP5 (3.1%) und TIMP3 (3.1%). For DAPK2, hMLH1, MGMT, p73, SOCS1 and TIMP2 no hypermethylation was detected. Hypermethylation of at least one gene was observed in 90.6% of the samples. Up to 7 of 17 gene promoter regions examined were concurrently methylated. …
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Elucidation of the occurrence of extracolonic cancers in Lynch syndrome
… 0.000181). Two tumour suppressor genes; HIC1 and TIMP3, were found to be methylated in the tumour samples in the germline/tumour tissue study. This study also showed instability of the Erβ gene in the majority of tumour samples. Bioinformatic analysis utilising existing microarray data resulted in …
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Untersuchungen zu Bedeutung von TGF-β während der Entwicklung des Vorderhirns
… Moleküle der extrazellulären Matrix wie Ctgf, Timp3, TenascinC und die Integrine α 3 und α 5, sowie Moleküle die eine regulierende Funktion auf TGF-β Signale selbst ausüben können wie Smad7, Igf2r und Fstl3. Durch die Regulation von Genen, die an der Übertragung von Notch- und Wnt-Signalen …
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Identifying genetic biomarkers for diagnosis of prostate cancer in South African men
… s <0.05; IGF1, PTEN, GSTP1, SOCS3, EGR3, GPX3, TIMP3, ZNF185, DKK3, PTGS2, FOXO1, ARNTL, TNFRSF10D, CCND1, and DLC1, upregulated genes included; CDH1, MKI67, TMPRSS2, ERG, CDKN2A, FASN, and AR but were not statistically significant. At a fold change threshold of 1.5, the following additional …
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Unraveling the mechanism of ADAMTS13 resistance to protease inhibition
Background: ADAMTS13 is a metalloprotease that regulates the delicate balance between VWF multimeric length and its platelet capturing capacity. Unlike other ADAMTS and coagulation proteases, ADAMTS13 exhibits a prolonged half-life of several days as an active protease, suggesting that it is …
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The Role of adipokines in obesity related beta-cell failure of diabetes mellitus and endothelial cell dysfunction of cardiovascular diseases.
… PCR for the expression of angiogenic (TIMP2, TIMP3 and MMP2) genes and atherosclerotic (LPA and LPL) genes. Leptin (1nM) was shown to increase the expression of atherosclerotic and angiogenic genes while adiponectin (100nM) inhibited the expression of the atherosclerotic and angiogenic genes. …