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Showing 1 to 20 of 25 for “"TIMP-2"”.
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Untersuchungen zur Expression der zellzyklusassoziierten Proteine p27Kip1 und Ki-67 und der Matrixmetalloproteinaseinhibitoren TIMP-1, TIMP-2 und TIMP-3 in häufigen humanen Karzinomen
Inhibitoren von Matrixmetalloproteinasen (TIMP) können das Wachstum von Zellen direkt beeinflussen und stellen somit wichtige Elemente des "extracellular signaling network" dar. p27Kip1 gehört zur Familie der cyclin-abhängigen Proteinkinase-Inhibitoren und bewirkt einen Stopp des Zellzyklus in der …
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Functional and structural uncoupling of the angiogenic and enzymatic inhibitory activity of TIMPs : loop 6 of TIMP-2 is a novel inhibitor of angiogenesis
Tissue inhibitors of metalloproteinases (TIMPs) regulate tumor growth, progression and angiogenesis in a variety of experimental cancer models and in human malignancies. However, numerous studies have revealed important differences between TIMP family members in their ability to inhibit angiogenic …
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Expression, activation, and regulation of matrix metalloproteinase 2 (MMP-2) in the bovine corpus luteum
… tissue inhibitors of metalloproteinases (TIMPs). Unlike most MMPs, pro-MMP-2 activation is accomplished on the cell surface rather than extracellularly. The objectives of the present study were to clone bovine cDNAs for MMP-2 and its activator, membrane type 1- (MT 1-)MMP, to investigate …
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Identification of seminal proteins related to fertility of bulls
… to tissue inhibitor of metalloproteinase-2 (TIMP-2). TIMP-2 regulates matrix metalloprotease activity and therefore, potentially plays a key role in the structural makeup of the extracellular matrix. These findings suggest that regulation of enzymatic activity in seminal fluid is in large …
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MMP's, TIMP's, PIIINP und Hyaluronan im Serum und Gewebe von Patientinnen mit Kapselfibrose nach alloplastischer Mammaaugmentation
… tissue-inhibitors of metalloproteinases, TIMPs, are in a physiological balance and part of the engineering of the extracellular matrix. Is this system disturbed an imbalance results and therefore fibrotic processes concerning liver fibrosis and lung fibrosis for example. In these cases the …
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Production of Extracellular Matrix-Degrading Proteases by a Rat B Cell Line.CRL-1631
… CRL-1631 eDNA revealing mRNA for MMP-2, MMP-9, TIMP-1, TIMP-2 and uPAR. MMP-2 and MMP-9 activity was verified by gelatin zymography. TIMP-1, TIMP-2 and uPAR protein expression was confirmed by Western blot analyses. I also report, for the first time, MT -1 MMP gene and protein expression in B …
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Enzymimmunologische und immunhistochemische Untersuchungen zum Einfluss von Matrix-Metalloproteinasen und ihrer Inhibitoren auf die Entstehung der Dupuytren'schen Kontraktur
… the tissue inhibitors of metalloproteinases (TIMPs), play an important role. In this study, serum concentrations of MMP-1, MMP-2, MMP-9, TIMP-1, and TIMP-2 were determined in 21 patients (five women and 17 men; average age, 67 ±11 years) with Dupuytren's disease using an enzyme-linked …
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Studies on Macrophage Migration in Pathological Contexts
… revealed that MMPs -8, -12, and-13 as well as TIMP-2 steady state mRNA levels were significantly up-regulated ATP, ATP can alter matrix remodelling. Macrophage recruitment is a significant player in atherosclerosis and may be modulated by Apolipoprotein E genotype. N3-polyunsaturated fatty …
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Effect of Methamphetamine on Gingival Fibroblast Production of Matrix Metalloproteinase (MMP)-2 and -9 and Tissue Inhibitor of Metalloproteinase (TIMP)-1 and -2 In Vitro
… ≥ 1x10<sup>-3</sup>M); MMP-2, MMP-9, TIMP-1,TIMP-2 and MMP:TIMP complexes in cell supernatants were measured by ELISA. MMP-2 activity was measured using the MMP-2 Biotrak Activity Assay System. Data were analyzed using ANOVA and Scheffe’s F procedure for post hoc comparisons.</p> …
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Der Einfluß von Zytokinen und Zell-Zell-Kontakten auf die Expression von Matrix-Metalloproteinasen beim multiplen Myelom
… (MMPs) and its specific inhibitors (TIMPs) represent a group of proteases that can degrade collagenous as well as non-collagenous extracellular matrix. Their expression is elevated in several tumor entities, and their influence on tumor progression and dissemination has been shown. …
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Der Einfluss von Matrix-Metalloproteinasen und ihrer Inhibitoren auf die Kapselbildung nach Mammaaugmentation mit texturierten und glattwandigen Silikongel-Implantaten
… tissue inhibitors of matrix metalloproteinases (TIMPs), play an important role. In my study, the relative expression of MMP-2,-9, TIMP-1 and-2 were determined in the capsular tissue of patients with capsular contracture after breast augmentation with silicone gel implants. The study included 20 …
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Inflammatory response in maternal serum during preterm labour
… MMP-3, tissue inhibitor of metalloproteinases (TIMP)-1, TIMP-2, TIMP-3 and TIMP-4 and a panel of 30 cytokines, chemokines and growth factors. Our study showed that serum levels of sTRE M-1 were elevated during spontaneous term and preterm labour vs. non-labouring women. sTRE M-1 concentrations …
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Analysis of biological pathways, associated with orthodontic force, using multiplex arrays
… IL-5, IL-6, IL-8, IL-10, TNF), tissue (MMP-9, TIMP-1 and 2) and bone metabolism (RANKL, OPG) biomarkers were measured. Results –IL-1β, IL-8, TNFα, MMP-9 increased in canine tension sites and TIMPs 1 and 2 from T2-T4, canine compression sites showed increases in IL-1β and IL-8 only at T2, MMP-9 …
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Color stability and phenolic composition from corn pericarp extracts in a beverage model and protective and anti-inflammatory potential of anthocyanin-rich plant extracts on celiac disease in vitro
… a 0.35 FI on metallopeptidase inhibitor 2 (TIMP-2) (p<0.05). Interleukin 11 and TIMP-2 are anti-inflammatory while IL-6 can be both anti- or pro-inflammatory and GM-CSF is pro-inflammatory. The ability of anthocyanin-rich plant extracts to inhibit CTP and JAK3 has positive implication for …
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Die Expression und Lokalisation von Matrix Metalloproteinasen (MMP) und ihrer spezifischen endogenen Inhibitoren (TIMP) in menschlichen primären Gehirntumoren
… (MMP) und ihrer spezifischen Inhibitoren (TIMP) in primären menschlichen Gehirntumoren zu beschreiben, und die Proteine im Gewebe zu lokalisieren. Ausganshypothese war, dass es bei der malignen Progression von Gliomen zu einer Zunahme der invasionsvermittelnden MMP und zu einer Abnahme der …
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Mathematical Modelling of Cancer Growth and Spread: The Role of Matrix Metalloproteinases
… with one another and their endogenous inhibitor TIMP-2. In Chapter 5 we develop the PDE model of cancer cell invasion to incorporate additional dynamics of the tissue and how these may hamper cancer cell invasion and tissue degradation. Further, we investigate how the tissue may be reconditioned …
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Biomarkers and Factors related to Risk of Acute Kidney Injury
… increase in novel urine biomarkers (UB), TIMP-2 and IGFBP7, has been linked to an increased risk of AKI.</p> <p><strong>Objectives: </strong>The purpose of this study was to examine the relationships among participants’ sociodemographic and clinical characteristics, including select …
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Charakterisierung und in vitro - Wirkung agonistischer AT1-Rezeptor Autoantikörper bei Präeklampsie-Patienten
… bzw. assoziierter Faktoren (Kollagen III, MMP-2, TIMP-2, Colligin) hin. In allen in dieser Arbeit untersuchten Seren von klinisch diagnostizierten Präeklampsie-Patientinnen wurden agonistische AT1-AAK nachgewiesen. Wir vermuten daher, dass die AT1-AAK möglicherweise bedeutend in der Pathogenese …
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Modulation of microRNA Functions by the 3’ Untranslated Regions of CD44 and Tumour Suppressor Candidate 2
… targets, tissue inhibitor of metalloproteinases (TIMP) -2 and -3.The 3’UTRs of these target mRNAs can bind and target multiple miRNAs in common with the TUSC2 3’UTR, which were confirmed with luciferase activity assays and correlated with a series of siRNA and miRNA assays. During the study of the …
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Proteomic Profiling of Pro and Active Matrix Metalloproteinases using Tandem Mass Spectrometry. Optimization of Affinity Chromatography and nHPLC-MALDI-MS/MS for Proteomic discrimination of Matrix Metalloproteinases in pre-clinical Cancer Model.
… and MMP- 14), and two endogenous inhibitors TIMP-1 and TIMP-2 were found in affinity chromatography eluates of cell culture supernatants with higher Mascot scores for the latter. While western blot detected MMP-2 in cell extracts, MALDI-MS/MS did not detect MMPs because of amounts below the …
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