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Showing 1 to 20 of 62 for “"TIMP-1"”.
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Biophysical studies of TIMP-1
… The first was the production and purification of TIMP-l. The second was a series of biophysical studies of TIMP-l and a TIMP-l derived peptide. A monoclonal antibody affinity column was developed and used to purifY large quantities of human TIMP-l for further experiments. Two E.coli expression …
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TIMP-1 as a Modulator of Inflammatory Pain
… tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) as an inhibitor of inflammatory hypersensitivity. In this work, we explore the mechanisms through which TIMP-1 achieves this. In our first set of experiments, we sought to identify targets downstream of TIMP-1 that were also involved in …
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TIMP-1: Zelluläre Funktion und Beeinflussung der Genexpression von Matrix-Metalloproteinasen in humanen Hepatomzellen
… MMP9 gens as well as how they are influenced by TIMP-1. For this purpose both certain kinases as well as their phosphorylated form (STAT 1, P-STAT 1, STAT 3, P-STAT-3, JAK 1, P-JAK 1, JAK 2, P-JAK 2, Ras GAP and JNK 1) were investigated by means of western blot analysis and western blot analysis …
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Analysis Of The Structure And Function Of A Timp-1/cd63 Complex And Its Relationship To An Mt1-Mmp/cd63 Complex
… The tissue inhibitors of metalloproteinases (TIMPs), of which there are four, are known for their broad metalloprotease inhibitory abilities. TIMP-1 has been widely studied as an inhibitor of matrix metalloproteinases (MMPs) and therefore as a molecule that prevents ECM degradation and …
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Untersuchungen zur Expression der zellzyklusassoziierten Proteine p27Kip1 und Ki-67 und der Matrixmetalloproteinaseinhibitoren TIMP-1, TIMP-2 und TIMP-3 in häufigen humanen Karzinomen
Inhibitoren von Matrixmetalloproteinasen (TIMP) können das Wachstum von Zellen direkt beeinflussen und stellen somit wichtige Elemente des "extracellular signaling network" dar. p27Kip1 gehört zur Familie der cyclin-abhängigen Proteinkinase-Inhibitoren und bewirkt einen Stopp des Zellzyklus in der …
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Effect of Methamphetamine on Gingival Fibroblast Production of Matrix Metalloproteinase (MMP)-2 and -9 and Tissue Inhibitor of Metalloproteinase (TIMP)-1 and -2 In Vitro
… ≥ 1x10<sup>-3</sup>M); MMP-2, MMP-9, TIMP-1,TIMP-2 and MMP:TIMP complexes in cell supernatants were measured by ELISA. MMP-2 activity was measured using the MMP-2 Biotrak Activity Assay System. Data were analyzed using ANOVA and Scheffe’s F procedure for post hoc comparisons.</p> …
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TIMP-1 Activates a Unique Cardiac Stem Cell Population, CD63+ve/C-KIT+ve, Thereby Enhancing Cardiac Differentiation, and Protects the Heart From Adverse Cardiac Remodeling Following Myocardial Infarction
… tissue inhibitor of metalloproteinase-1 (TIMP-1) have increased potential to engraft and differentiate into cardiac myocytes following transplantation into the infarcted heart. However, the ability of TIMP-1 to activate endogenous stem cells and enhance their differentiation into cardiac …
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A novel function of tissue inhibitor of metalloproteinase-1 as a chemoattract molecule for neural stem cells
… study, we reported one candidate protein, TIMP-1, commonly expressed from microarray and proteomic data. Imuunostaining showed that expression of TIMP-1 is up-regulated in all glioma tissues compared to normal brain tissues. In addition, TIMP-1 dramatically induced migration of NSCs, but …
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Μελέτη του ρυθμιστικού ρόλου του παράγοντα αναστολής της μετανάστευσης των μακροφάγων (MIF) στην επίδραση των κορτικοειδών στην παραγωγή μεταλλοπρωτεασών και των ενδογενών αναστολέων τους, κυτταροκινών και κολλαγόνου στο ρινικό πολύποδα
… IL-6 η MMP-1, η MMP-3 το κολλαγόνο τύπου-Ι και ο TIMP-1, που εμπλέκονται στη παθογένεια του ρινικού πολύποδα (ΡΠ). Ο MIF ανιχνεύθηκε στο μέσο καλλιέργειας όλων των ιστών και σε όλα τα εκχυλίσματα. Η έκφρασή του ήταν αυξημένη στον ρινικό πολύποδα σε σχέση με τον φυσιολογικό ρινικό βλεννογόνο. O …
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Induzierter Zelltod von transdifferenzierten hepatischen Sternzellen (Myofibroblasten) auf der Basis des Thymidinkinase-Ganciclovir-Systems
… inhibitor of metalloproteinases-1-promoter (h-TIMP-1-promoter), which is known as a strongly activated promoter within progressive liver fibrosis. Shuttle vector and recombinant replication-defective adonovirus was generated, containing the h-TIMP-1 / thymidine kinase transgene. After …
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Enzymimmunologische und immunhistochemische Untersuchungen zum Einfluss von Matrix-Metalloproteinasen und ihrer Inhibitoren auf die Entstehung der Dupuytren'schen Kontraktur
… the tissue inhibitors of metalloproteinases (TIMPs), play an important role. In this study, serum concentrations of MMP-1, MMP-2, MMP-9, TIMP-1, and TIMP-2 were determined in 21 patients (five women and 17 men; average age, 67 ±11 years) with Dupuytren's disease using an enzyme-linked …
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Estudio de la expresión de las metaloproteasas (MMP) 7 y 14 así como del inhibidor tisular de las metaloproteasas tipo 1(TIMP-1) en el cáncer de colon asociado o no a la enfermedad inflamatoria crónica intestinal (Enfermedad de Crohn y colitis ulcerosa)
… al inhibidor tisular-1 de las metaloproteasas (TIMP-1), con el desarrollo y progresión del cáncer colorrectal esporádico (CCR-S). Sin embargo, pocos estudios analizan su participación en el CCR-EII. El programa de cribado para la detección precoz del CCR-EII o la displasia tisular es más …
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Der Einfluss von Matrix-Metalloproteinasen und ihrer Inhibitoren auf die Entstehung chronischer Wunden
… the tissue inhibitors of metalloproteinases (TIMP´s), play a central role in the process of physiological wound healing. In the present study levels of MMP-2, -8 and -9, as well as TIMP-1 and -2 were measured in fluids of different chronic wounds on day 0, 5, 14, 28, 42 and 56 by ELISA. The …
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Staphylococcus aureus의 Lipoteichoic acid(LTA)에 의한 사람의 정상 코 점막 상피세포에서의 MMP와 TIMP의 발현
… 확인 Ⅲ. 결과 A. LTA에 의한 코 점막 상피세포의 세포독성 확인 B. MMP-9와 TIMP-1, -2 유전자의 발현 차이 C. MMP-9와 TIMP-1, -2의 분비량 차이 D. 분비 된 MMP-9(gelatinase B)의 활성 확인 E. ERK1/2, STAT3의 발현 F. ERK1/2를 매개로 MMP-9 발현 Ⅳ. 고찰 Ⅴ. 결론 참고문헌 ABSTRACT "
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Mechanisms of Erythropoietin-induced Neuroprotection in: in-vivo and in-vitro Models of hypoxia Ischema
… tissues inhibitor of matrix metalloproteinase (TIMP)-1 and inhibition of hypoxia inducible factor (HIF-1α) both of which subsequently decreased in matrix metalloproteinase (MMP)-9 and promoted neuroprotection. MMP-9 inhibition was associated with neuroprotection in both pathways thus, inferring …
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Inflammation-associated gene regulation in primary astrocytes, glial tumors and cellular differentiation
… tumors. First, we analyzed the mechanism of TIMP-1 activation in astrocytes and glioblastoma cells. TIMP-1 expression is activated by IL-1, which is the major neuroinflammatory cytokine, via simultaneous activation of IKK/NF-kB and MEK3/6/p38/ATF-2 pathways in primary human astrocytes. In …
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Comparison of Plasma MMP and TIMP Concentration Related to Albumine Excretion Rate in Type 2 Diabetes
… 병력 청취, 신체 계측을 시행하고 ELISA법으로 혈청 MMP-2, MMP-9, TIMP-1 농도를 측정하였다. 결과: 혈청 MMP-2, MMP-9, TIMP-1 농도를 측정한 결과 MMP-2와 MMP-9의 농도는 각 군에서 차이를 보이지 않았으며 TIMP-1은 단백뇨가 많이 배설되는 군 일수록 통계학적으로 유의하게 혈청 농도가 증가되는 결과를 나타내었다. 결론: 당뇨병성 신증의 특징인 세포 외 기질의 분해 감소 및 침착 증가가 일어나는 과정에서 TIMP-1이 영향을 미칠 것으로 보인다. "
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