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Showing 1 to 20 of 49 for “"TIMP-1"”.
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Biophysical studies of TIMP-1
… The first was the production and purification of TIMP-l. The second was a series of biophysical studies of TIMP-l and a TIMP-l derived peptide. A monoclonal antibody affinity column was developed and used to purifY large quantities of human TIMP-l for further experiments. Two E.coli expression …
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TIMP-1 as a Modulator of Inflammatory Pain
… tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) as an inhibitor of inflammatory hypersensitivity. In this work, we explore the mechanisms through which TIMP-1 achieves this. In our first set of experiments, we sought to identify targets downstream of TIMP-1 that were also involved in …
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Analysis Of The Structure And Function Of A Timp-1/cd63 Complex And Its Relationship To An Mt1-Mmp/cd63 Complex
… The tissue inhibitors of metalloproteinases (TIMPs), of which there are four, are known for their broad metalloprotease inhibitory abilities. TIMP-1 has been widely studied as an inhibitor of matrix metalloproteinases (MMPs) and therefore as a molecule that prevents ECM degradation and …
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Untersuchungen zur Expression der zellzyklusassoziierten Proteine p27Kip1 und Ki-67 und der Matrixmetalloproteinaseinhibitoren TIMP-1, TIMP-2 und TIMP-3 in häufigen humanen Karzinomen
Inhibitoren von Matrixmetalloproteinasen (TIMP) können das Wachstum von Zellen direkt beeinflussen und stellen somit wichtige Elemente des "extracellular signaling network" dar. p27Kip1 gehört zur Familie der cyclin-abhängigen Proteinkinase-Inhibitoren und bewirkt einen Stopp des Zellzyklus in der …
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Effect of Methamphetamine on Gingival Fibroblast Production of Matrix Metalloproteinase (MMP)-2 and -9 and Tissue Inhibitor of Metalloproteinase (TIMP)-1 and -2 In Vitro
… ≥ 1x10<sup>-3</sup>M); MMP-2, MMP-9, TIMP-1,TIMP-2 and MMP:TIMP complexes in cell supernatants were measured by ELISA. MMP-2 activity was measured using the MMP-2 Biotrak Activity Assay System. Data were analyzed using ANOVA and Scheffe’s F procedure for post hoc comparisons.</p> …
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TIMP-1 Activates a Unique Cardiac Stem Cell Population, CD63+ve/C-KIT+ve, Thereby Enhancing Cardiac Differentiation, and Protects the Heart From Adverse Cardiac Remodeling Following Myocardial Infarction
… tissue inhibitor of metalloproteinase-1 (TIMP-1) have increased potential to engraft and differentiate into cardiac myocytes following transplantation into the infarcted heart. However, the ability of TIMP-1 to activate endogenous stem cells and enhance their differentiation into cardiac …
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A novel function of tissue inhibitor of metalloproteinase-1 as a chemoattract molecule for neural stem cells
… study, we reported one candidate protein, TIMP-1, commonly expressed from microarray and proteomic data. Imuunostaining showed that expression of TIMP-1 is up-regulated in all glioma tissues compared to normal brain tissues. In addition, TIMP-1 dramatically induced migration of NSCs, but …
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Μελέτη του ρυθμιστικού ρόλου του παράγοντα αναστολής της μετανάστευσης των μακροφάγων (MIF) στην επίδραση των κορτικοειδών στην παραγωγή μεταλλοπρωτεασών και των ενδογενών αναστολέων τους, κυτταροκινών και κολλαγόνου στο ρινικό πολύποδα
… IL-6 η MMP-1, η MMP-3 το κολλαγόνο τύπου-Ι και ο TIMP-1, που εμπλέκονται στη παθογένεια του ρινικού πολύποδα (ΡΠ). Ο MIF ανιχνεύθηκε στο μέσο καλλιέργειας όλων των ιστών και σε όλα τα εκχυλίσματα. Η έκφρασή του ήταν αυξημένη στον ρινικό πολύποδα σε σχέση με τον φυσιολογικό ρινικό βλεννογόνο. O …
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Estudio de la expresión de las metaloproteasas (MMP) 7 y 14 así como del inhibidor tisular de las metaloproteasas tipo 1(TIMP-1) en el cáncer de colon asociado o no a la enfermedad inflamatoria crónica intestinal (Enfermedad de Crohn y colitis ulcerosa)
… al inhibidor tisular-1 de las metaloproteasas (TIMP-1), con el desarrollo y progresión del cáncer colorrectal esporádico (CCR-S). Sin embargo, pocos estudios analizan su participación en el CCR-EII. El programa de cribado para la detección precoz del CCR-EII o la displasia tisular es más …
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Staphylococcus aureus의 Lipoteichoic acid(LTA)에 의한 사람의 정상 코 점막 상피세포에서의 MMP와 TIMP의 발현
… 확인 Ⅲ. 결과 A. LTA에 의한 코 점막 상피세포의 세포독성 확인 B. MMP-9와 TIMP-1, -2 유전자의 발현 차이 C. MMP-9와 TIMP-1, -2의 분비량 차이 D. 분비 된 MMP-9(gelatinase B)의 활성 확인 E. ERK1/2, STAT3의 발현 F. ERK1/2를 매개로 MMP-9 발현 Ⅳ. 고찰 Ⅴ. 결론 참고문헌 ABSTRACT "
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Mechanisms of Erythropoietin-induced Neuroprotection in: in-vivo and in-vitro Models of hypoxia Ischema
… tissues inhibitor of matrix metalloproteinase (TIMP)-1 and inhibition of hypoxia inducible factor (HIF-1α) both of which subsequently decreased in matrix metalloproteinase (MMP)-9 and promoted neuroprotection. MMP-9 inhibition was associated with neuroprotection in both pathways thus, inferring …
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Inflammation-associated gene regulation in primary astrocytes, glial tumors and cellular differentiation
… tumors. First, we analyzed the mechanism of TIMP-1 activation in astrocytes and glioblastoma cells. TIMP-1 expression is activated by IL-1, which is the major neuroinflammatory cytokine, via simultaneous activation of IKK/NF-kB and MEK3/6/p38/ATF-2 pathways in primary human astrocytes. In …
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Comparison of Plasma MMP and TIMP Concentration Related to Albumine Excretion Rate in Type 2 Diabetes
… 병력 청취, 신체 계측을 시행하고 ELISA법으로 혈청 MMP-2, MMP-9, TIMP-1 농도를 측정하였다. 결과: 혈청 MMP-2, MMP-9, TIMP-1 농도를 측정한 결과 MMP-2와 MMP-9의 농도는 각 군에서 차이를 보이지 않았으며 TIMP-1은 단백뇨가 많이 배설되는 군 일수록 통계학적으로 유의하게 혈청 농도가 증가되는 결과를 나타내었다. 결론: 당뇨병성 신증의 특징인 세포 외 기질의 분해 감소 및 침착 증가가 일어나는 과정에서 TIMP-1이 영향을 미칠 것으로 보인다. "
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Regulation of Matrix Metalloproteinases and Their Inhibitors by DNA Methylation in Human Gestational Tissues
… tissue inhibitors of metalloproteinases (TIMPs) are key mediators of fetal membrane rupture during physiological and pathological labour. Membrane type MMPs (MT-MMPs) activate secreted MMPs in addition to degrading the extracellular matrix (ECM); however, their role in fetal membrane …
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Production of Extracellular Matrix-Degrading Proteases by a Rat B Cell Line.CRL-1631
… CRL-1631 eDNA revealing mRNA for MMP-2, MMP-9, TIMP-1, TIMP-2 and uPAR. MMP-2 and MMP-9 activity was verified by gelatin zymography. TIMP-1, TIMP-2 and uPAR protein expression was confirmed by Western blot analyses. I also report, for the first time, MT -1 MMP gene and protein expression in B …
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Analysis of biological pathways, associated with orthodontic force, using multiplex arrays
… IL-5, IL-6, IL-8, IL-10, TNF), tissue (MMP-9, TIMP-1 and 2) and bone metabolism (RANKL, OPG) biomarkers were measured. Results –IL-1β, IL-8, TNFα, MMP-9 increased in canine tension sites and TIMPs 1 and 2 from T2-T4, canine compression sites showed increases in IL-1β and IL-8 only at T2, MMP-9 …
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Expression, activation, and regulation of matrix metalloproteinase 2 (MMP-2) in the bovine corpus luteum
… tissue inhibitors of metalloproteinases (TIMPs). Unlike most MMPs, pro-MMP-2 activation is accomplished on the cell surface rather than extracellularly. The objectives of the present study were to clone bovine cDNAs for MMP-2 and its activator, membrane type 1- (MT 1-)MMP, to investigate …
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Die Expression und Lokalisation von Matrix Metalloproteinasen (MMP) und ihrer spezifischen endogenen Inhibitoren (TIMP) in menschlichen primären Gehirntumoren
… (MMP) und ihrer spezifischen Inhibitoren (TIMP) in primären menschlichen Gehirntumoren zu beschreiben, und die Proteine im Gewebe zu lokalisieren. Ausganshypothese war, dass es bei der malignen Progression von Gliomen zu einer Zunahme der invasionsvermittelnden MMP und zu einer Abnahme der …
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Blood-Based Inflammation Biomarkers of Neurocognitive Impairment in People Living with HIV
… speed. Tissue inhibitor of metalloproteinases-1 (TIMP-1) significantly correlated with the aforementioned domains except memory and processing speed. In addition, interleukin (IL) - 23 significantly associated with executive functioning and processing speed. The biomarkers demonstrated a negative …
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