Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"TIM-3"”.
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The Effect of Tim-3-Ig on Tumor Growth
Tim-3, a member of the novel TIM (T cell immunoglobulin- and mucin-containing-domain) family of molecules, is the first molecule identified to be specifically expressed on CD4+ Th1 and not on Th2 cells. Tim-3 negatively regulates Th1 immunity and induces tolerance, but it's function has not been …
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Tim-3 and Cell Death in Murine Mercury Induced Autoimmunity
… targeting the nucleolar protein fibrillarin. Tim proteins are a family of immune cell surface molecules that have been implicated in modulation of autoimmune diseases in both humans and animals. Tim-3, originally reported as a Th1 specific molecule, is expressed on T cells of various subsets, …
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Regulation of TIM-3 Expression in Mast cells and Monocytes
T cell immunoglobulin mucin domain 3 (TIM-3) which is a type-I membrane protein, is expressed on differentiated Th1 cell, mast cell and monocyte. Although expression of TIM-3 and its ligand galectin-9 has been demonstrated in mast cells, the transcriptional regulation of these molecules has not …
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Upstream conserved sequence element that regulates TIM-3 induction in CD4+ T cell
… T cell immunoglobulin domain and mucin domain-3 (TIM-3) was discovered in Th1 and has been known as a T cell regulatory molecule. TIM-3 expression is induced by T cell activation through mechanism not yet well-investigated. In the study, I wanted to find DNA region involved in regulation of TIM-3 …
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Identification of Regulatory DNA Region and Transcription Factors Important for TIM-3 Transcription
TIM-3는 T 세포 immunoglobulin- and mucin-domain-containing molecules (TIMs) family의 하나로서 보조 T 세포 1형에서 특이적으로 발현하는 분자로 발견되었다. 이 분자는 비만세포에서도 발현이 되며 TGF-β에 의해 발현이 증가한다고 알려졌으나 분자생물학적인 발현기작에 대해서는 연구되지 않았다. 본 연구에서는 TIM-3의 분자생물학적인 발현조절기작을 밝히기 위해 TIM-3 upstream DNA와 intron 1과 2를 각각 포함하는 luciferase reporter …
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Development of monoclonal antibodies targeting T cell coinhibitory proteins TIM-3 and TIM-4
… like T cell immunoglobulin mucin 3 and 4 (TIM-3 and TIM-4), stems from trying to improve the efficacy of ICI therapies (e.g. against cytotoxic T-lymphocyte antigen 4 (CTLA-4) and/or programmed cell death protein 1 (PD-1)) which are currently being used to treat certain cancers like breast, …
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Regulation Mechanisms of TIM-3 expression in Jurkat T cells and HMC-1 cells
… immunoglobulin, and mucin domain-3(TIM-3)는 TIM family에 속하는 분자로 마우스 Th1 세포에 특이적인 세포 막 단백질로 처음 발견되었다. 이 분자는 T 세포와 비만세포 이외에도 대식세포, 수지상세포 등 면역에 관여하는 다양한 세포에서도 발현된다고 알려져 있다. 현재까지 TIM-3가 면역 반응에서 중요한 기능을 한다는 보고가 많이 되고 있는 반면 TIM-3 발현 조절 기작에 대해서는 많이 밝혀지지 않았다. 본 연구에서는 T 세포주와 비만 세포주에서 TIM-3의 발현 …
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Methylation Change of Histone H3 and CpG Sites at the TIM-3 Gene Promoter in Response to Stimulation
T cell immunoglobulin and mucin protein-3 (TIM-3)는 면역 반응을 조절하는 분자로써 CD11b+ 세포에서 항상 발현하지만 CD4+ T 세포에서는 자극에 의해 활성화 되었을 때 발현한다고 알려져 있다. 본 연구에서는 epigenetic 조절에 따른 TIM-3 전사 조절을 이해하기 위하여 T 세포를 사용하여 TIM-3 promoter에서의 epigenetic 변형을 분석하였다. 먼저 DNA methyltransferase inhibitor인 5-Azacytidine을 Jurkat T 세포에 …
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Differential Expression of T Cell Immunoglobulin- and Mucin-Domain-Containing Molecule-3 (TIM-3) According to Activity of Behçet's Disease
BACKGROUND: T cell immunoglobulin mucin-3 (TIM-3) is recently described as a TH1-associated cell surface molecule that regulates TH1 responses and promotes tolerance in mice. Increased TH1 immune response has been known as one possible pathogenesis of a chronic inflammatory multisystemic disorder, …
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The role of T cell Immunoglobulin Mucin domain in Herpes Simplex Virus-induced Behçet’s Disease mouse model
The T cell immunoglobulin mucin (TIM) proteins regulate T cell activation and tolerance. Individual TIM family members may serve as susceptibility markers for asthma, allergies and autoimmune diseases, as well as potential cell surface markers for T helper type (Th)1 and Th2 T cells. TIM-1 plays an …
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Il-6/Jak1 Drives Pd-L1 Phosphorylation and Glycosylation to Promote Cancer Immune Evasion
… to anti-T-cell immunoglobulin mucin-3 (Tim-3) immune checkpoint therapies in animal models. These results identify a mechanism regulating initiation of PD-L1 glycosylation and suggest that the combination of anti-IL-6 and anti-Tim-3 is an effective, biomarker-driven, therapeutic strategy …
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The novel roles of BCL6 and BATF3 in regulating human CD8⁺ T cell dysfunction
… Here, we developed an in vitro repeated stimulation model to recapitulate features of human CD8⁺ T cell dysfunction and delineate transcriptional and epigenetic landscapes. Our analyses revealed that BCL6 and BATF3 are robustly upregulated in dysfunctional CD8⁺ T cells, with ATAC-seq …
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Differential gene expression in Behcet's disease and differential anti-tumor effects of Tim3 pathway blocking molecules
… to distinguish colchicine responsiveness. I stimulated peripheral blood mononuclear cells (PBMCs) and CD11b+ cells of BD patients with lipopolysaccharide (LPS) and analyzed the expression of inflammatory cytokines, transcription factors and microRNAs. Compared to colchicine-responsive BD …
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Equipping Members for Biblical Counseling Ministry at Rock Hill Baptist Church in Greenville, South Carolina
… 2 presents an exegesis of pertinent Scripture (2 Tim 3:16-17; Eph 4:7-16; Gal 5:25-6-6; and Rom 15:1-6) to support the thesis that the Bible instructs the act of communicating biblical truths for the sanctification of fellow believers. Chapter 3 is an essay on practical methodologies for enhancing …
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Teaching Members the Power of a Clear Conscience at Twin City Bible Church in Winston-Salem, North Carolina
… from four passages (Rom 2:12–15; Heb 9:9–14; 2 Tim 3:9; 1 Sam 24:5–15). Chapter 3 examines the applicational considerations related to the importance of teaching the church the biblical view of the conscience. Chapter 4 describes the details related to implementing this ministry project as well …
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Revising the Pastoral Theology Program at Shepherds Theological Seminary in Cary, North Carolina
… exegesis of three passages of Scripture (1 Tim 3:1-7; 1 Tim 4:6-16; 2 Tim 2:1-6) to show that the pastor must possess a variety of traits and skills. In addition, one key adjective related to pastoral competency and nineteen key Greek words related to pastoral ministry are observed and …
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Equipping Members of Annville Baptist Church in Annville, Kentucky, to Faithfully Practice Biblical Hermeneutics
… of five passages of Scripture (2 Pet 3:15-16; 2 Tim 2:1419; 2 Tim 3:16-17; Heb 4:11-13; Matt 28:16-20) that show the necessity for believers to have a biblical hermeneutic in their reading and study of God’s Word. Chapter 3 highlights the hermeneutical significance of authorial intent, …
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Teaching Biblical Counseling Principles at San Francisco Bible Church, San Francisco, California
… exegesis of five passages of Scripture (Ps 19; 2 Tim 3:14-17; Col 3:1-17; Rom 15:1-13; Eph 4:7-16) to show that God has provided every Christian with all that they need to care for one another through his Word. Chapter 3 explored the theoretical and practical foundations for biblical counseling. …
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Equipping Churches to Disciple College Students at the Baptist Collegiate Ministry in Tallahassee, Florida
… of four passages of Scripture (1 Cor 2:10-16; 2 Tim 3:14-17; 2 Tim 2:2, Titus 2) to show that the effective discipleship of college students is possible through the Holy Spirit, God’s Word, and the local church. Chapter 3 addressed what effective discipleship is, and the importance of the …
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Equipping the Eighth Grade Boys at Immanuel Christian School in Springfield, Virginia, to Understand and Practice Spiritual Disciplines
… 2 provides four biblical passages (Ps 1:1-3; 2 Tim 3:16-17; 1 Tim 4:7-12; Titus 2:1-6) to lay the foundation to show that understanding and developing spiritual disciplines is vital to the spiritual life of young men. Chapter 3 shares how understanding biblical discipleship and educational …
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