Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"TIM-3"”.
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The Effect of Tim-3-Ig on Tumor Growth
Tim-3, a member of the novel TIM (T cell immunoglobulin- and mucin-containing-domain) family of molecules, is the first molecule identified to be specifically expressed on CD4+ Th1 and not on Th2 cells. Tim-3 negatively regulates Th1 immunity and induces tolerance, but it's function has not been …
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Tim-3 and Cell Death in Murine Mercury Induced Autoimmunity
… targeting the nucleolar protein fibrillarin. Tim proteins are a family of immune cell surface molecules that have been implicated in modulation of autoimmune diseases in both humans and animals. Tim-3, originally reported as a Th1 specific molecule, is expressed on T cells of various subsets, …
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Regulation of TIM-3 Expression in Mast cells and Monocytes
T cell immunoglobulin mucin domain 3 (TIM-3) which is a type-I membrane protein, is expressed on differentiated Th1 cell, mast cell and monocyte. Although expression of TIM-3 and its ligand galectin-9 has been demonstrated in mast cells, the transcriptional regulation of these molecules has not …
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Upstream conserved sequence element that regulates TIM-3 induction in CD4+ T cell
… T cell immunoglobulin domain and mucin domain-3 (TIM-3) was discovered in Th1 and has been known as a T cell regulatory molecule. TIM-3 expression is induced by T cell activation through mechanism not yet well-investigated. In the study, I wanted to find DNA region involved in regulation of TIM-3 …
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Identification of Regulatory DNA Region and Transcription Factors Important for TIM-3 Transcription
TIM-3는 T 세포 immunoglobulin- and mucin-domain-containing molecules (TIMs) family의 하나로서 보조 T 세포 1형에서 특이적으로 발현하는 분자로 발견되었다. 이 분자는 비만세포에서도 발현이 되며 TGF-β에 의해 발현이 증가한다고 알려졌으나 분자생물학적인 발현기작에 대해서는 연구되지 않았다. 본 연구에서는 TIM-3의 분자생물학적인 발현조절기작을 밝히기 위해 TIM-3 upstream DNA와 intron 1과 2를 각각 포함하는 luciferase reporter …
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Development of monoclonal antibodies targeting T cell coinhibitory proteins TIM-3 and TIM-4
… like T cell immunoglobulin mucin 3 and 4 (TIM-3 and TIM-4), stems from trying to improve the efficacy of ICI therapies (e.g. against cytotoxic T-lymphocyte antigen 4 (CTLA-4) and/or programmed cell death protein 1 (PD-1)) which are currently being used to treat certain cancers like breast, …
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Regulation Mechanisms of TIM-3 expression in Jurkat T cells and HMC-1 cells
… immunoglobulin, and mucin domain-3(TIM-3)는 TIM family에 속하는 분자로 마우스 Th1 세포에 특이적인 세포 막 단백질로 처음 발견되었다. 이 분자는 T 세포와 비만세포 이외에도 대식세포, 수지상세포 등 면역에 관여하는 다양한 세포에서도 발현된다고 알려져 있다. 현재까지 TIM-3가 면역 반응에서 중요한 기능을 한다는 보고가 많이 되고 있는 반면 TIM-3 발현 조절 기작에 대해서는 많이 밝혀지지 않았다. 본 연구에서는 T 세포주와 비만 세포주에서 TIM-3의 발현 …
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Methylation Change of Histone H3 and CpG Sites at the TIM-3 Gene Promoter in Response to Stimulation
T cell immunoglobulin and mucin protein-3 (TIM-3)는 면역 반응을 조절하는 분자로써 CD11b+ 세포에서 항상 발현하지만 CD4+ T 세포에서는 자극에 의해 활성화 되었을 때 발현한다고 알려져 있다. 본 연구에서는 epigenetic 조절에 따른 TIM-3 전사 조절을 이해하기 위하여 T 세포를 사용하여 TIM-3 promoter에서의 epigenetic 변형을 분석하였다. 먼저 DNA methyltransferase inhibitor인 5-Azacytidine을 Jurkat T 세포에 …
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Differential Expression of T Cell Immunoglobulin- and Mucin-Domain-Containing Molecule-3 (TIM-3) According to Activity of Behçet's Disease
BACKGROUND: T cell immunoglobulin mucin-3 (TIM-3) is recently described as a TH1-associated cell surface molecule that regulates TH1 responses and promotes tolerance in mice. Increased TH1 immune response has been known as one possible pathogenesis of a chronic inflammatory multisystemic disorder, …
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The role of T cell Immunoglobulin Mucin domain in Herpes Simplex Virus-induced Behçet’s Disease mouse model
The T cell immunoglobulin mucin (TIM) proteins regulate T cell activation and tolerance. Individual TIM family members may serve as susceptibility markers for asthma, allergies and autoimmune diseases, as well as potential cell surface markers for T helper type (Th)1 and Th2 T cells. TIM-1 plays an …
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Il-6/Jak1 Drives Pd-L1 Phosphorylation and Glycosylation to Promote Cancer Immune Evasion
… to anti-T-cell immunoglobulin mucin-3 (Tim-3) immune checkpoint therapies in animal models. These results identify a mechanism regulating initiation of PD-L1 glycosylation and suggest that the combination of anti-IL-6 and anti-Tim-3 is an effective, biomarker-driven, therapeutic strategy …
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The novel roles of BCL6 and BATF3 in regulating human CD8⁺ T cell dysfunction
… Here, we developed an in vitro repeated stimulation model to recapitulate features of human CD8⁺ T cell dysfunction and delineate transcriptional and epigenetic landscapes. Our analyses revealed that BCL6 and BATF3 are robustly upregulated in dysfunctional CD8⁺ T cells, with ATAC-seq …
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Differential gene expression in Behcet's disease and differential anti-tumor effects of Tim3 pathway blocking molecules
… to distinguish colchicine responsiveness. I stimulated peripheral blood mononuclear cells (PBMCs) and CD11b+ cells of BD patients with lipopolysaccharide (LPS) and analyzed the expression of inflammatory cytokines, transcription factors and microRNAs. Compared to colchicine-responsive BD …
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Role Of Il-27 And Tcr Stimulation In Inhibitory Receptor Expression
… CD4+ and CD8+ T cells in the absence of TCR stimulation. TCR stimulation induced expression of multiple inhibitory receptors and IL- 27 combined synergistically with TCR stimulation to further upregulate Ly6C, LAG-3, CTLA-4, TIGIT and TIM-3. This IL-27-mediated inhibitory expression was STAT1- …
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Mechanistic and Functional Characterization of B and T Lymphocyte Attenuator (Btla) In Cd8 Tumor Infiltrating Lymphocytes
… of other co-inhibitory molecules such as PD-1, TIM-3, and Lag3 did not associate with response. BTLA is expressed by T cells, B cells, and NK cells and serves as a T cell differentiation maker whereby high expression of BTLA associates with less differentiated T cell phenotype. While the …
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Investigating Tumour-Immune Cell Interactions in Paediatric Malignancies
… that high pre-treatment expression of PTEN, TIM-3, CD127, and markers of NK-cells and M1 macrophages and low expression of VISTA and CD40L were associated with improved overall survival. Collectively, this work provides novel insights into tumour-immune interactions across paediatric …
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Immunomodulation in Adenovirus-Induced Viral Hepatitis
… the expression of CD8 T cell inhibitory markers (Tim-3 and PD-1) also decreased. Our findings suggest to us that HGF mediates organ protection by promoting hepatocyte survival, but like IL-33, it does not abolish viral clearance. In summary we have described the hepatoprotective and …