Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 451 for “"TIM"”.
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Development of monoclonal antibodies targeting T cell coinhibitory proteins TIM-3 and TIM-4
… like T cell immunoglobulin mucin 3 and 4 (TIM-3 and TIM-4), stems from trying to improve the efficacy of ICI therapies (e.g. against cytotoxic T-lymphocyte antigen 4 (CTLA-4) and/or programmed cell death protein 1 (PD-1)) which are currently being used to treat certain cancers like breast, …
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Metafiction in the work of Tim O'Brien
This thesis explores Tim O'Brien's ideas on the definition of fiction, memory, imagination, the role they play in the creative process, and the functions that fiction has in the world at large. This will be explored through close examination of O'Brien's self-referential narrative technique. This …
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The Effect of Tim-3-Ig on Tumor Growth
Tim-3, a member of the novel TIM (T cell immunoglobulin- and mucin-containing-domain) family of molecules, is the first molecule identified to be specifically expressed on CD4+ Th1 and not on Th2 cells. Tim-3 negatively regulates Th1 immunity and induces tolerance, but it's function has not been …
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Tim-3 and Cell Death in Murine Mercury Induced Autoimmunity
… targeting the nucleolar protein fibrillarin. Tim proteins are a family of immune cell surface molecules that have been implicated in modulation of autoimmune diseases in both humans and animals. Tim-3, originally reported as a Th1 specific molecule, is expressed on T cells of various subsets, …
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Regulation of TIM-3 Expression in Mast cells and Monocytes
T cell immunoglobulin mucin domain 3 (TIM-3) which is a type-I membrane protein, is expressed on differentiated Th1 cell, mast cell and monocyte. Although expression of TIM-3 and its ligand galectin-9 has been demonstrated in mast cells, the transcriptional regulation of these molecules has not …
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O imaginário fantástico de Tim Burton : exemplos de gótico moderno
Dissertação de mestrado em Estudos Americanos apresentada à Universidade Aberta
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Reading Through Displacement: Functionality of the Underlying Theme in Tim O'Brien's Fiction
Tim O'Brien, a contemporary author writing mostly about his combat experience in Vietnam, has written eight books to date. All involve Vietnam in some way—overtly, for the most part. He and his stories are well known stylistically for several traits including the blurred distinctions between what …
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Upstream conserved sequence element that regulates TIM-3 induction in CD4+ T cell
… T cell immunoglobulin domain and mucin domain-3 (TIM-3) was discovered in Th1 and has been known as a T cell regulatory molecule. TIM-3 expression is induced by T cell activation through mechanism not yet well-investigated. In the study, I wanted to find DNA region involved in regulation of TIM-3 …
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Identification of Regulatory DNA Region and Transcription Factors Important for TIM-3 Transcription
TIM-3는 T 세포 immunoglobulin- and mucin-domain-containing molecules (TIMs) family의 하나로서 보조 T 세포 1형에서 특이적으로 발현하는 분자로 발견되었다. 이 분자는 비만세포에서도 발현이 되며 TGF-β에 의해 발현이 증가한다고 알려졌으나 분자생물학적인 발현기작에 대해서는 연구되지 않았다. 본 연구에서는 TIM-3의 분자생물학적인 발현조절기작을 밝히기 위해 TIM-3 upstream DNA와 intron 1과 2를 각각 포함하는 luciferase reporter …
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Preaching to Provoke a Worldview Change: Tim Keller's Use of Presuppositional Apologetics in Preaching
ABSTRACT PREACHING TO PROVOKE A WORLDVIEW CHANGE: TIM KELLER'S USE OF PRESUPPOSITIONAL APPOLOGETICS IN PREACHING Travis Allen Freeman Doctorate of Philosophy The Southern Baptist Theological Seminary 2011 Hershael W. York This dissertation examines the preaching methodology of Tim Keller. It argues …
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Regulation Mechanisms of TIM-3 expression in Jurkat T cells and HMC-1 cells
… immunoglobulin, and mucin domain-3(TIM-3)는 TIM family에 속하는 분자로 마우스 Th1 세포에 특이적인 세포 막 단백질로 처음 발견되었다. 이 분자는 T 세포와 비만세포 이외에도 대식세포, 수지상세포 등 면역에 관여하는 다양한 세포에서도 발현된다고 알려져 있다. 현재까지 TIM-3가 면역 반응에서 중요한 기능을 한다는 보고가 많이 되고 있는 반면 TIM-3 발현 조절 기작에 대해서는 많이 밝혀지지 않았다. 본 연구에서는 T 세포주와 비만 세포주에서 TIM-3의 발현 …
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Wear-resistant thermal interface material (TIM) for quad/octal small form factor pluggable (QSFP/OSFP) modules
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-08-01
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Methylation Change of Histone H3 and CpG Sites at the TIM-3 Gene Promoter in Response to Stimulation
T cell immunoglobulin and mucin protein-3 (TIM-3)는 면역 반응을 조절하는 분자로써 CD11b+ 세포에서 항상 발현하지만 CD4+ T 세포에서는 자극에 의해 활성화 되었을 때 발현한다고 알려져 있다. 본 연구에서는 epigenetic 조절에 따른 TIM-3 전사 조절을 이해하기 위하여 T 세포를 사용하여 TIM-3 promoter에서의 epigenetic 변형을 분석하였다. 먼저 DNA methyltransferase inhibitor인 5-Azacytidine을 Jurkat T 세포에 …
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The Conversation About the Keys: Original Plays - Part I: Tim Without Thalia; Part II: Thalia With Someone Else
… never really figured out what Last Love did." "Tim Without Thalia" and "Thalia With Someone Else" sprung from a place of being tired, but not yet sleepy. The "quarter-life crisis" if you will: When everyone else seems to be getting married, having kids, starting their own basket-weaving …
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Biblical Lessons for Educational Leaders: The Servant Leadership of King David, Apostle Paul, Dr. Joe Hairston, Dr. Tim Markley
<p>This qualitative research study used the methodology of historical documentation. Primary and secondary sources were gathered alongside of the original sources for Servant Leadership as espoused by Robert Greenleaf in "The Servant as Leader" (1970). The New International Version (NIV) of the …
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Visibilitas hilal dalam penetapan awal Ramadlan dan Syawal menurut perspektif Tim Hisab dan Dewan Masyayikh Pondok Pesantren Miftahul Huda Gading
… tentang bagaimana visibilitas hilal perspektif Tim Hisab dan Dewan Masyâyikh PP. Miftahul Huda? Karena mengingat banyaknya pendapat terkait dengan bisa atau tidaknya hilal dapat dilihat/dirukyat. Bagaimana pula metode visibilitas hilal yang mereka gunakan dalam menetapkan awal Ramadlan dan …
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Differential Expression of T Cell Immunoglobulin- and Mucin-Domain-Containing Molecule-3 (TIM-3) According to Activity of Behçet's Disease
BACKGROUND: T cell immunoglobulin mucin-3 (TIM-3) is recently described as a TH1-associated cell surface molecule that regulates TH1 responses and promotes tolerance in mice. Increased TH1 immune response has been known as one possible pathogenesis of a chronic inflammatory multisystemic disorder, …
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