Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"TIGIT"”.
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Delivery of sting agonist using lipid nanoparticles and discovery of anti-TIGIT peptides for cancer therapy
… second research involves the discovery of anti-TIGIT cyclic peptides using phage biopanning to block the interaction between the receptor TIGIT and its high-affinity ligand, CD155. In clinical studies, inhibiting this pathway within the adaptive immune system has demonstrated the ability to …
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The impacts of psychological stress on innate-like invariant T cell survival, phenotype, and function
… with immunoglobulin and ITIM domains (TIGIT) in a GR-dependent manner and blockade of TIGIT partially restores their functional capacity in stressed mice. Ultimately, in a GR-dependent fashion, iNKT cells from stressed mice fail to prevent pulmonary metastases of B16 melanoma. MAIT …
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Role Of Il-27 And Tcr Stimulation In Inhibitory Receptor Expression
… to further upregulate Ly6C, LAG-3, CTLA-4, TIGIT and TIM-3. This IL-27-mediated inhibitory expression was STAT1- dependent. The response to TCR stimulation was graded and thus a stronger TCR stimulus resulted in greater inhibitory receptor expression. In vivo, during infection with …
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IL-27 AND THE REGULATION OF INNATE AND ADAPTIVE IMMUNITY DURING TOXOPLASMOSIS
… cell expression of inhibitory receptors (such as TIGIT and PD-L1) contributed to this activity. In chapter 2, the role of TIGIT during infection was assessed and indicated it was not a critical mediator of the suppressive effects of IL-27. In chapter 3, the impact of IL-27 neutralization on acute …
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Διερεύνηση των καρκινικών Τ κυττάρων στο δερματικό Τ κυτταρικό λέμφωμα
… και έντονο εξαντλημένο φαινότυπο (PD-1, LAG3, TIGIT και CTLA-4), ενώ παράλληλα εμφανίζονται εγκλωβισμένα σε ένα πλήρως αναδιαμορφωμένο CAF μικροπεριβάλλον. Tα κακοήθη CD4⁺CD7-CD26-CCR4hi Τ κύτταρα στην MF είναι ικανά να συμβάλλουν στην ανοσολογική ρύθμιση μέσω της οδού PD-1/PD-L1, αλλά δεν …
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Modulation of Pi3K-Akt Pathway In Colorectal Cancer
… Agilent microarrays, we found higher PD-L1 and TIGIT mRNA levels in PI3K-altered MSS CRC (PPIK3CA<sup>mut</sup> MSS CRC patients derived clinical benefit more frequently than <em>PIK3CA</em> wild-type patients (50% vs 8.6%, P=0.015). We further showed synergism of combined PI3K and PD-1 …
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Bhlhe40: Required For Tumor Microenvironment Remodeling and Immune Checkpoint Therapy Efficacy
… expression of the inhibitory receptor gene <em>Tigit</em> and displayed alterations in chemokine/chemokine receptor gene expression with altered gene expression of granzyme family members. Mice lacking BHLHE40 had reduced ICT-driven IFNg production by CD4<sup>+</sup> and CD8<sup>+</sup> T cells …
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HIGH-THROUGHPUT PROFILING OF INNATE IMMUNE CELLS TO UNVEIL TUMOR ESCAPE MECHANISMS IN MATCHED COLORECTAL CANCER AND LIVER METASTASES
… and multiple inhibitory receptors, including TIGIT, CXCR4, and SIGIRR, reflecting a paradoxical state of activation restrained by layered inhibitory checkpoints. Finally, integrative analyses resolved a highly heterogeneous γδ T cell landscape across blood, CRC, and CRLM. Vδ1 T cells …
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THE ROLE OF CD4+ T MEMORY SUBSETS IN HIV INFECTION: IMMUNE RESPONSE IN PEOPLE WITH HIV AND LATENCY ESTABLISHMENT
… (defined as TSCM and TCM co-expressing PD-1 and TIGIT) in PWHIV with incomplete immune reconstitution. In these participants, TCF-1, a master regulator of T cell stemness, was less expressed across all T memory subsets. It has been recently shown that GSK3β inhibition could arrest CD8+ T cell …