Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"THY1"”.
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Investigating pathological mechanisms in the Thy1-hTDP43 ALS mouse model
… the use of an external stressor using the Thy1-hTDP-43 mouse model. At the late symptomatic disease stage, we found a significant upregulation of SG formation in spinal motor neurons, significant upregulation of SG formation markers in both brain and spinal cord tissue at both the protein …
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Developing tools to investigate neuronal activity in synaptic pruning /
… organotypic hippocampal slice culture using Thy1::EGFP mice to provide robust labeling of excitatory pyramidal neurons of hippocampus in maturing brain tissue. Second, we used Thy1::EGFP, RC::LSL-tdTomato, Cx3cr1::Cre mice to visualize direct interactions between neurons and microglia. Third, …
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Der Einfluss von Chemokinen auf die Migration von naiven und Effektor-CD8-T-Zellen in der Milz
… Durch die Verwendung eines allelischen Thy1-Markers konnte im adoptiven Transfersystem zwischen den LCMV-spezifischen Donorzellen der tg Mäuse und den Rezipientenzellen normaler Mäuse unterschieden werden. Nach einem Transfer fanden sich naive tg Zellen in der Milz überwiegend in der …
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MiniFAST: A Fast and Sensitive Microscope for in vivo Neural Imaging
… a GEVI and ~300-Hz in vivo imaging of transgenic Thy1-GCaMP6f mice. Finally, we show the potential for a reduction in photobleaching effects by using high gain imaging with ultra-low excitation light power (0.05mW) at 60 Hz frame rates while still resolving Ca2+ spiking activity. Our results …
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Clomeleon Biosensor-Mauslinien zur optophysiologischen Bestimmung der intrazellulären Chloridkonzentration in Nervenzellen
… generiert, die den Indikator unter Kontrolle des Thy1-Promotors exprimieren. Die Linien unterschieden sich in dem Expressionsmuster von Clomeleon. Generell wurde in diesen Linien eine weitverbreitete und hohe Expression des Indikators gefunden. Diese Mauslinien sind für Populations-Imaging gut …
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Charakterisierung humaner kurz-zeitrepopulierender Blutstammzellen im NOD/SCID-ß2m-/- Xenotransplantationsmodell
… wurden mPB Zellen in CD34+Thy1+ und CD34+Thy- Populationen aufgetrennt und in Xenotransplantationsexperimente durch serielle FACS Analyse der Knochenmaraspirate das Kurzzeitrepopulationsverhalten dieser Populationen in NOD/SCID-ß2m-/- Mäusen untersucht. Dabei konnte gezeigt …
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Uncovering functional mechanisms in cancer through integrative genomics
The genome has been called the blueprint of life for it encodes a complete set of genetic instructions that specify the precise design and timing of functional molecules (such as RNAs and proteins) responsible for carrying out all cellular processes. In recent years, the human genome, comprised of …
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Molecular Characterization of Male Breast Cancer
Cancer is today a major healthcare problem worldwide. There are many forms of cancer, which is a genetic disease, believed to result from a multistep process with genetic and epigenetic changes accumulating over time. Breast cancer is one of the most common forms of cancer in women, while it is …