Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"THP-1 macrophages"”.
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Novel cytokines in innate immunity: IL-27 and IL-30 enhance responsiveness to gram-negative bacterial components in human myeloid cells
… endotoxin (LPS) tolerance in human monocytes and macrophages, while the effects of IL-30 are defined in human monocytes. IL-27 and IL-30 induce IP-10 production in human monocytes in a STAT-dependent manner. Furthermore, pre-treatment with IL-6 interferes with IL-27 and IL-30 functions in human …
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Investigating Bacterial Filamentation as a Survival Strategy for Infection
… engulfment by phagocytic immune cells like macrophages. Bacterial filamentation, as a strategy to avoid engulfment during infections, is a possible virulence pathway that has been highlighted in previous research but is yet to be fully explored. Investigations in this area could reveal novel …
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MyD88-Mediated Signaling in Protective Immunity against an Attenuated West Nile Virus Infection
… to young DCs. I also used two human cell lines-THP-1 and THP-1 macrophages to study the immune response following NS4B-P38G infection. NS4B-P38G mutant produced more viral RNA than parental NY99 in both cell types and boosted higher innate cytokine responses with no detectable infective virus. …
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Investigation of ACE-overexpression in Myeloid Cell Lines through Whole-Proteome Analysis
… of angiotensin II, ACE overexpression in murine macrophages (ACE 10/10) and neutrophils (NeuACE) has shown remarkable enhanced immune phenotypes with the ability to improve murine survival against B16 melanoma, methicillin-resistant Staphylococcus aureus (MRSA) and Listeria monocytogenes. Current …
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¿CHIOS MASTIC GUM FROM PISTACIA LENTISCUS AS A MODULATOR OF INFLAMMATION AND INTESTINAL BARRIER FUNCTION: AN IN VITRO AND CLINICAL INVESTIGATION.¿
… Caco-2 cells and lipopolysaccharide-stimulated THP-1 macrophages. Clinically, no significant differences were observed in the questionnaires and calprotectin levels, although a downward trend was noted for the latter (p=0.062). Faecal zonulin levels showed a significant decrease over time …
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The effects of E-cigarettes on pulmonary inflammation and inflammasome activation
… nicotine, as liquids and vapours, to human macrophages and epithelial cells. A549 epithelial cells, THP-1 macrophages and primary macrophages isolated from smoking and non-smoking individuals were treated with E-liquid, E-vapours and inflammasome stimuli. <br/><br/>E -vapours and liquids …
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The effects of biophysical and biochemical cues on tendon cells: a study of underlying mechanisms in tendinopathy
… was prepared. hTDCs viability, and hTDC and THP-1 macrophage gene expression were characterised. Rat-TDC (rTDC) were treated with palmitic acid (PA), with cell viability, gene expression and reactive oxygen species (ROS) production characterised. Genipin treatment was hypothesised to restore …
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The role of ERK5 signalling in macrophage behaviour during wound healing
… the role of a key immune cell in wound healing: macrophages and how a known regulator of macrophages in other contexts, ERK5, influences wound healing, using genetic and therapeutic manipulations targeted at ERK5, both in vitro and in vivo. Genetic in vivo hyperactivation of ERK5 causes a …
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Deciphering the molecular basis of the global emergence of non-tuberculous Mycobacteria as important human respiratory pathogens
… replication and persistence of M. avium in human THP-1 macrophage-like cells and assess new drug treatments. Accuracy of fluorescence signal as proxy of intracellular replication was confirmed against the gold standard technique of CFU plating. Moreover, the assay was validated using a panel of …
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The effect of testosterone on factors associated with diabetes, atherosclerosis and obesity.
… culture were studied including human macrophage THP-1 cells and mouse 3T3L1 cells to study the effect of testosterone with or without blocked androgen receptor (AR) on CX3CR1 and CCR2 and pro-inflammatory cytokines in macrophage cells and on adiponectin, PP ARB/o, PAI-1, leptin and chemokines in …
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A study of the metabolic immune responses produced by some natural products
Macrophages play a crucial role in inflammatory conditions by producing a range of pro-inflammatory molecules, including cytokines, nitric oxide and reactive oxygen species (ROS). Several studies have demonstrated the physiological and inflammatory responses of macrophages to different stimuli, …
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Mechanisms underlying Leishmania parasites survival and dissemination at late stage of infection in human macrophages
… parasites to disseminate between human macrophages. It is assumed that parasites could exit macrophages following cell lysis. However, there is still a major gap in knowledge in understanding the exact mechanism pertaining to this critical step. This has been partially caused by the lack …
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Characterisation of dysregulated proteins in macrophages infected with Mycobacterium smegmatis focusing on matrix metalloproteases and their effectors
… induced by Mycobacterium smegmatis (M. smeg) in THP-1 macrophages is central to understanding its avirulent nature especially its effects on MMPs. The aim of this study was to evaluate the role of MMP-1 and MMP-9, and their effectors in macrophages infected with M. smeg. Differentiated THP-1 …
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Role of Vitamin-D3 and Retinoic Acid In A Human Thp-1 Macrophage Model of Mycobacterium Tuberculosis Infection
… tuberculosis (Mtb) replicates within the human macrophages and we investigated the activating effects of retinoic acid (RA) and vitamin D3 (VD) on macrophages in relation to the viability of Mtb. A combination of these vitamins (RAVD) enhanced the receptors on THP-1 macrophage (Mannose receptor …
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Bifidobacterial interactions with human milk oligosaccharides and their combined potential for the advancement of infant nutrition
… using Caco-2 intestinal epithelial cells and THP-1 macrophages to simulate the intestinal environment. This model enabled the examination of immune responses under controlled conditions. The research design incorporated quantitative methodologies, including multiplex ELISA, to assess changes …
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18F-markierte S100-Proteine als potentielle Radioliganden für die funktionelle Charakterisierung des Rezeptors für advanced glycation endproducts (RAGE) in vitro und in vivo
… (HAEC) und an zu Makrophagen differenzierten THP-1-Zellen (THP-1-Makrophagen) verifiziert. Für die Untersuchung der RAGE-Bindung war die Produktion des löslichen sRAGE bzw. die Generation von flRAGE-berexprimierenden Zellen erforderlich. Beide Konstrukte wurden in geeigneten Zellsystemen …