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Showing 1 to 2 of 2 for “"TGR5"”.
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Role of TGR5 in Bile Acid Metabolism
TGR5 is a G protein-coupled bile acid receptor present in various tissues in the body. Its agonism increases energy expenditure and lowers blood glucose. Thus, it is an attractive drug target for treating human metabolic disease. However, TGR5 is highly expressed in the gallbladder, where its …
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VERTICAL SLEEVE GASTRECTOMY IMPROVES GLUCOSE HOMEOSTASIS VIA [beta]- CELL GLUCAGON-LIKE PEPTIDE-1 RECEPTOR SIGNALING BUT PROMOTES COLITIS DEVELOPMENT IN MICE
Bariatric surgery is defined as the surgical manipulation of the gut for the purpose of weight loss. Currently, it is the most effective long-term treatment for obesity and results in multiple cardiometabolic benefits. However, the mechanisms by which these benefits occur remain incompletely …