Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 50 for “"TGN"”.
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PI(4)P-Dependent Recruitment of Clathrin Adaptors to the Trans-Golgi Network
The Trans Golgi Network (TGN) is the cell's central sorting station, and the complex trafficking patterns are organized by many types of trafficking adaptors. These include the heterotetrameric adaptor protein complexes (APs) and the monomeric Golgi-localized, gamma-ear containing, Arf-binding …
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Sorting of Cargo Proteins Within the Regulated Secretory Pathway: the Peripheral Membrane Protein HID-1 as a Sorting and Vesicle Biogenesis Factor
… (LDCVs) form at the trans-Golgi network (TGN) and mediate the regulated release of neuropeptides and peptide hormones. Despite their central role to physiology, the mechanisms controlling biogenesis and sorting to LDCVs is not well understood. Optimizing the retention using selective hooks …
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Lipid rafts in protein sorting and yeast cell polarity
… surface or secretion is the trans Golgi Network, TGN. This organelle sorts proteins and lipids into vesicular transport carriers that are targeted via different pathways to distinct membrane compartments of the cell. The molecular principles that operate in cargo sorting at the TGN are still not …
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Double-stranded RNA uptake in Caenorhabditis elegans
… apical membrane and the trans-Golgi-network (TGN). This localization is dependent on sid-3 and its potential substrate viro-2, hence demonstrating a molecular interplay between the different SID proteins. The spatial organisation of SID-2 is conserved across species, suggesting a role for the …
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Exploring the Impact of Endothelial Bone Morphogenetic Protein Receptor 2 Loss on Phosphoinositide and Cytoskeletal Assembly Dynamics and the Pathobiology of Pulmonary Arterial Hypertension
… trafficking between the trans-Golgi network (TGN) and plasma membrane (PM) is vital for protein secretion and growth factor signaling, which involves recycling and PM localization of cell surface receptors. These processes depend on the cytoskeleton and the presence of phosphoinositide (PI) …
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A novel principle for immunomodulator delivery with hematopoietic cells as vehicles Focus on soluble TNF-receptor gene expression, targeting to secretory lysosomes and regulated secretion
… sTNFR1-tm-Y from the trans-Golgi network (TGN) to secretory lysosomes, followed by generation of membrane-free soluble sTNFR1. The secretion of sTNFR1 could be triggered by a calcium-ionophore or by crosslinking of the IgE receptors on mast cells leading to degranulation. In contrast, …
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Culturally Informed Motivational Interviewing to Improve Oral Chemotherapy Adherence for Pediatric Acute Lymphoblastic Leukemia Patients and Their Caregivers: A Feasibility, Acceptability, and Preliminary Efficacy Trial
… caregiver-reported 6-MP adherence, patients' TGN blood serum levels, and caregiver-perceived 6-MP adherence barriers. METHOD: Participants included 121 caregivers (Age M(SD) = 36.66(8.02), 80.7% mothers, 47.1% Hispanic, 23.1% Spanish-speaking) of pediatric ALL patients (Age M(SD) = 7.55(4.80), …
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The Role of ER-Golgi Membrane Contact Sites and of FAPP1 in Phosphoinositide Homeostasis at the Golgi Complex
… with and stimulating SAC1 at the level of ER-TGN membrane contact sites (ERTGoCS). At these ERTGoCS, FAPP1 acts as an adaptor that directs and stabilizes SAC1 towards PI4P-rich domains to promote its activity in trans to dephosphorylate PI4P at the TGN. Consequently, FAPP1 depletion leads to a …
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Somatostatin Receptor 2 Regulation By C-Terminal Motifs and Pdz Domain Proteins
… and then on to the trans-golgi network (TGN). Trafficking from late endosomes to the TGN is dependent upon an intact C-terminal tail and the retromer complex of endosomal coat proteins. Additionally, removing either 3 or 10 C-terminal amino acids from sst2 alters the pathway through which …
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Characterization of the Human Adenovirus 19a E3/49K Protein
… At steady-state, E3/49K is detected in the Golgi/TGN, early endosomes and at the cell surface of Ad19a-infected as well as 49K-transfected cells. The cytoplasmic tail, which contains two potential endosomal/lysosomal targeting motifs, YXXF and LL, plays a major role in the 49K trafficking. The …
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Novel regulators of trafficking in the yeast Golgi-endosomal system
… better understanding of Pik1p function at the TGN and to isolate new regulators of post-Golgi transport in yeast. I identified a total of 85 genes, whose deletion resulted in a synthetic growth defect when combined with the pik1-101 mutation. 21 isolated deletion mutants were used for further …
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Regulatory domains of the Arf GEF Sec7 scaffold autoinhibited and active conformations
… The final compartment, the trans-Golgi Network (TGN), connects the Golgi to the endomembrane system and balances the flow of membranes and cargo throughout the cell. Virtually all sorting and transport at the TGN is dependent on the small GTPase Arf1 which drives vesicle formation and membrane …
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An investigation of the function of adaptor protein complex 4 (AP-4)
… in protein sorting at the trans-Golgi network (TGN), so AP-4 deficiency can be thought of as a disease of missorting. The aim of this study was to apply unbiased global proteomic approaches to define the composition of AP-4 vesicles and to identify physiological cargo proteins of the AP-4 …
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Studies on the structural organization of Golgi complex
… Sialyltransferase (SialylT, tans- Golgi/TGN), galactosyltransferase(GalT, trans-Golgi/TGN), and Nacetylglucosametransferase- 1 (GlcNAcT-1, medial-Golgi), during the process of Golgi disassembly and reassembly following the addition or removal of drugs. After 1 h nocodazole (microtubule …
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A novel pathway for VLDL assembly in the mouse liver
… intrazellulären Kompartiment, wahrscheinlich dem TGN oder dem "recycling endosome", transportiert, um lipidiert und als VLDL, in geringerem Umfang auch als IDL, sezerniert zu werden. Diese Daten beweisen, dass als LDL endozytiertes apoB100 zur Synthese von VLDL wiederverwendet werden kann. Eine …
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Charakterisierung der endosomalen Qb-SNAREs Vti1a und Vti1b
… Transport von den frühen Endosomen zum TGN könnte der Grund für die Umverteilung sein. Der langsamere Transport von endozytierten Markern in Endobrevin/Vti1b-doppeldefizienten Zellen spricht gegen eine Kompensation der Vti1b-Defizienz durch einen komplett anderen SNARE-Komplex. Eine …
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Involvement of the lysosomal cysteine peptidase cathepsin B in tumour progression and formation of metastases
… and metastasis, transgenic mice FVB/N-TgN(MMTVPyVT)634Mul, developing multifocal metastasising mammary carcinomas, were utilised. CTSB deficient mice, with a mixed C57BL/6J and 129SvJ background were made congenic for the FVB/N strain. FVB/N-TgN(MMTVPyVT)-CTSB, wt, ht and ko were …
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Antizyme Inhibitor 2 : A Novel Regulator of Cellular Polyamine Homeostasis
… localize mainly to the trans-Golgi network (TGN). Depletion of AZIN2 or cellular polyamines causes selective fragmentation of the TGN and retards secretion of proteins. Since addition of exogenous polyamines reverses these effects, the data indicate that AZIN2 and its downstream effectors, …
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Analyse des besoins technologiques des apprenants à distance à la Télé-université
… avons appliqué la technique du groupe nominal (TGN). Nous avons également augmenté la banque d’énoncés en y ajoutant : - les commentaires des concepteurs et des tuteurs de la Télé-université, lorsque nous les avons sollicités pour valider notre question nominale; - les propositions d’étudiants …
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Vector Embedding Techniques for Player Behaviour in DOTA 2
… the vectors 60 and 10 times faster than LINE and TGN, respectively, on the same amount of data.
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