Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"TGFbeta"”.
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TGF-beta 1 PATHWAY AND AGE-RELATED MACULAR DEGENERATION
… formulation demonstrated remarkable levels of TGFbeta-1 in the posterior segment of the eye. In particular, high levels of TGFbeta-1 were detected in the vitreous after 240 minutes (Tmax) from the topical application of the eye drops. The tested formulation was well tolerated and the score for …
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Reduction of tumorigenesis in androgen receptor overexpressed Huh7 cells through TGF-β induced cellular senescence phenotypes
… was studied by infection of dominant negative TGFbeta-RII adenovirus (TGFbeta RII DN-Ad); The reduced growth rate and other cellular senescence phenotypes were significantly recovered after TGFbeta RII DN-Ad infection, compared with the infection of its control viruses. The above data strongly …
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Computational Modeling and Simulation Study of Dermal Wound Healing Proliferative Phase
… wound healing proliferative phase by embedding a TGFbeta pathway to each fibroblasts. The subcellular level model is an ODE system and the cellular level model is a hybrid agent-based model of fibroblast migration, proliferationg and collagen production. Our model clearly shows how varying …
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Molecular Genetics of Endocrine Induced Regression of Mouse Leydig Cell Tumors
… cell tumor RNA, it was shown that c-fos, c-myc, TGFbeta and p53 are induced during regression. In contrast, the expression of the TRPM-2 gene (a marker for programmed cell death) was constitutive in both growing and regressing Leydig cell tumors; DNA isolated from growing and regressing tumors …
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Structure and activity of human clusterin.
… and apo AI-HDL in addition to immunoglobulins, TGFbeta receptors, heparin and the endocytic receptor LRP2. Little is known of clusterin structure and function. Sequences modeled as amphipathic alpha helices have been proposed as promiscous binding sites(s) for hydrophobic ligands. A reanalysis …
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Proliferation von Lungenfibroblasten in vitro unter dem Einfluss von ionisierender Strahlung bzw. von TGF-Beta 1
Die Lunge wird häufig im Rahmen der Behandlung maligner Tumoren im Thorax bestrahlt und stellt aufgrund ihrer hohen Radiosensitivität das dosislimitierende Organ dar. Es kann zu Nebenwirkungen in Form von akuter Strahlenpneumonitis bis hin zu chronischer Lungenfibrose kommen. Bei diesen Prozessen …
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The functions of pregnancy-associated plasma protein A in rheumatoid arthritis.
… LPS alone.Binding of PAPP-A to IL-1alpha and TGFbeta was studied using [125]I-cytokines. Formation of PAPP-A cytokine complexes was determined using either native SDS PAGE or gel filtration chromatography. No evidence of cytokine binding was obtained. The binding of PAPP-A to human cartilage …
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Cytokines and human endometrial function: Abnormalities in recurrent miscarriage women.
… were also investigated. IL-1alpha, TNFalpha and TGFbeta caused a significant increase in IL-11 production from both stromal and epithelial cells. Finally the effects of IL-11 on MMP-2, MMP-9, MMP-7, IL-1beta and TNFalpha produced by cultured endometrial cells were studied. No effect of IL-11 on …
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EGF module-containing mucin-like hormone receptor 2 and its role in human immune privilege
PURPOSE: In the mouse, the macrophage adhesion G protein-coupled receptor (ad-GPCR) molecule, F4/80, is required for the development of regulatory T cells in two models of tolerance, the eye and gut. Since F4/80 is not expressed in humans, the purpose of this research is to determine the human …