Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"TGFb signalling"”.
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Mechanisms underlying enhanced bone marrow adipogenesis in diabetes
… with suppressed transforming growth factor beta (TGFB) signalling pathway. Using bone marrow-derived mesenchymal progenitor cells (bm-MPCs), I then investigated the functional significance of TGFB signalling suppression. My studies showed that exposure of bm-MPCs to high levels of glucose …
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Common genetic variance at the SMAD9 colorectal cancer risk locus influences tumour mutational phenotype
… part of the Transforming Growth Factor Beta (TGFb) signalling pathway, with tumour suppressive functions in early CRC. I suggested that the eQTL may selectively favour tumours with or without further mutations of TGFb signalling dependent on SMAD9 expression. The correlation with MSS and MSI …
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SMAD2/3 - FOXH1 regulation during cell cycle progression upon differentiation
… to be elucidated. Indeed, the activity of TGFβ signalling via its downstream effector SMAD2/3 is directed by cell cycle regulators and especially cyclin Ds. Indeed, cyclin Ds direct cell fate propensity either by activating CDK4/6 activity, which results in blocking SMAD2/3 nuclear entry or by …