Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"TGFb"”.
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Mechanisms underlying enhanced bone marrow adipogenesis in diabetes
… with suppressed transforming growth factor beta (TGFB) signalling pathway. Using bone marrow-derived mesenchymal progenitor cells (bm-MPCs), I then investigated the functional significance of TGFB signalling suppression. My studies showed that exposure of bm-MPCs to high levels of glucose …
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Quantitative Single-Cell Imaging Reveals Insulation of Morphogenic Signal Transduction
… between Wnt and Transforming Growth Factor Beta (TGFB), which are key developmental pathways. Surprisingly, this insulation extends to the integration of signals within the TGFB superfamily, which are expected to compete for shared components and so interfere with one another during signal …
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In vivo and in vitro regulation of plasminogen activator inhibitor type-1
… human hepatoma cells, the cells treated with TGFB for 24 hours after which luciferase activity was measured as a function of promoter activity. The active regions were also analyzed by gel retardation to investigate the transcription factors that bound to these regions. The functional data …
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Regulation of Human Osteosarcoma Cell Differentiation by Transforming Growth Factor B1 (TGFB and 1a,25- Dihydroxyvitamin D3 : the Mechanism of TGFB1 Potentiation of 1,25D3-induced Alkaline Phosphatase Activity in Human MG63 Osteosarcoma Cell
<p>Transforming growth factor β<sub>1 </sub>(TGFβ<sub>1</sub>) is a pluripotent cytokine that works in conjunction with other cytokines to modulate their effects on cell function. Our previous work demonstrated that the combination of TGFβ<sub>1</sub> and 1α,25-dihydroxyvitamin D<sub>3</sub> had a …
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Fibroblasts: Key Cells in Inflammation and Fibrosis
… II infusion. Ang II is also a potent inducer of TGFb, a cytokine that promotes fibroblast to myofibroblast transdifferentiation. We hypothesized that TGFb induces myofibroblast transdifferentiation via activation of fibroblast-RelA, an event that may precede the development of vascular …
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Proepicardial Cell Differentiation During Cardiac Development
… phenomenons were inhibited by the addition of a TGFb family inhibitor (SB 431542). Our studies indicate that members of the TGFb family of proteins, specifically the combination of TGFb1, 2 and 3, are critical regulators of this process. PE cells cultured with the combination of TGFb1, 2 and 3, …
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Common genetic variance at the SMAD9 colorectal cancer risk locus influences tumour mutational phenotype
… part of the Transforming Growth Factor Beta (TGFb) signalling pathway, with tumour suppressive functions in early CRC. I suggested that the eQTL may selectively favour tumours with or without further mutations of TGFb signalling dependent on SMAD9 expression. The correlation with MSS and MSI …
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Coordinated regulation of the snail family of transcription factors by the notch and tgf-0 pathways during heart development
… Slug family member, Snail is regulated by the TGFB pathway in endothelial cells. While Notch does not directly regulate Snail expression, Notch and TGFB act synergistically to regulate Snail expression in endothelial cells. It is further demonstrated that Slug is required for Notch mediated …
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The role of genetic and environmental variation in the respiratory phenotype of alpha 1 antitrypsin deficiency
… TNFA with chronic bronchitis, SFTPB with FEV1, TGFB with small airways disease and GC with bronchiectasis, consistent with the role of protein products in pathogenesis. Of four MMPs studied, association with gas transfer occurred in two. HLA-DQA1*0301 and HLA-DRB1*04 contributed significantly to …
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Functional Heterogeneity and Metabolic Adaptation of Fibroblasts In Cancer
… a previously reported mouse model in which Tgfb signaling in fibroblasts has shown to modulate epithelial growth, resulting in squamous carcinoma of the forestomach. In our studies, we uncovered a complex feed forward loop, in which the loss of Tgfb receptor 2 in FSP1+ fibroblasts leads to a …
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Expression and role of the extracellular matrix protein tenascin in ovarian cancer
… have been investigated. Several factors (IGF II, TGFB, progesterone and EGF) stimulate TN secretion by fibroblasts while other factors (gonadotrophins and interferon) inhibit TN secretion in the same cell type. Of the factors studied TGF-B provided the greatest induction of TN in fibroblasts. None …
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Exploring the methylome and transcriptome of young adult and aged OPCs
… in microglia are a result of the increase in TGFb levels with ageing. In summary, this dissertation introduces new tools and methods that will allow x further in-depth study of adult OPCs, and specifically will help to shed light on the role of adult OPCs in the CNS in homeostasis. …
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C-Rel Is A Transcriptional Target of Mesoderm Inducer In Xenopus Like 1 (Mixl1)
… homeobox transcription factor induced by BMP4/TGFb signaling, is a critical regulator of embryonic and adult hematopoiesis. Several lines of evidence implicate MIXL1 in hematopoietic transformation: (i) Aberrant MIXL1 expression is seen in human CML ( Chronic Myelogenous Leukemia) in blast …
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THE ROLE OF OMEGA 3 FATTY ACIDS IN CAPSULAR CONTRACTURE AROUND THE BREAST IMPLANTS
… contraction, evaluating the thickness, and tgfb expression on sample of capsule collected in a rat living model. Materials and Methods:32 Wild-type C57BL/6 knockout mice were bred and maintained in a university vivarium.The animals were divided in two groups: Omega3/control. Mice were …
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Impact Of Cryoablation On Tumor Immunity
… (Il10 and Il4) and suppression (Foxp3 and Tgfb). Recurrences of tumors treated with cryoablation occurred in 26-29% of WT mice which was significantly decreased to 0% with the addition of CpG. </p> <p>Conclusions: These findings suggest cryoablation induces a Th2 dominant response, which …
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SMAD2/3 - FOXH1 regulation during cell cycle progression upon differentiation
Throughout development, balance between differentiation and proliferation is key to ensure the proper induction of the initial layout of the future body plan and to later produce the correct amounts of each cell type. While the characteristics of cell cycle regulation in pluripotent and …
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Immune gene expression and diversity in relation to gastrointestinal parasite burden in small mammals
… interleukin Il10 and tumor necrosis factor Tgfb production. Both cytokines in turn cause an abated MHC expression. By disabling recognition by the MHC molecule H. polygyrus might be able to prevent an activation of the immune system. Indeed, I found a strong tendency in animals carrying the …
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Enhancing Adoptive Cell Therapy By Augmenting Fitness and Anti-Tumor Function of Tumor-Infiltrating Lymphocytes
<p>The success of immune checkpoint inhibitors (ICIs) has established the importance of cancer immunotherapy in solid cancers, where it has been adopted as one of the standards of care for advanced melanoma and lung cancer. It is currently being investigated to treat other solid cancers. However, a …
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The evolutionary transition from reptiles to mammals: analyses of body size reduction and separation of middle ear elements from the jaw
… in a handful of key genes (including Tgfbr2, Wisp1, Mmp9 and Ctsk) responsible for promoting apoptosis, bone breakdown, and cartilage resorption. Through verification with fluorescent in situ hybridization (FISH), all of these factors were shown to increase in expression level as they …
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Characterisation of T cell responses to proteins expressed during Human Cytomegalovirus latency
Human cytomegalovirus (HCMV) is a betaherpesvirus that establishes a lifelong infection in hosts. In the majority of cases, the immune response to primary HCMV infection limits viral replication and dissemination, such that overt clinical disease is prevented. However, the immune system cannot …