Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"TGF-beta1"”.
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Evaluierung synergistischer Effekte von rhBMP-2-Mutanten und TGF-Beta1 bei der induzierten Knochenbildung : eine In-vivo-Studie in Ratten
… veränderte Mutanten T3 und T4, jeweils mit rhTGF-ß1 kombiniert. Das Ziel der Studie bestand darin, nachzuweisen, ob TGF-ß1 die osteoinduktive Potenz dieser BMPs steigert. Als Proteinkonzentrationen wurden 0,5µg und 1µg des jeweiligen Proteins gewählt. Des Weiteren wurde untersucht, ob rhTGF-ß1 …
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Einfluss von Transforming Growth Factor-beta1 (TGF-[beta]1) Genpolymorphismen auf die Hepatitis-C-induzierte Leberfibrose in vivo und Modulation der TGF-[beta]1-Synthese, Prozessierung und Sekretion durch die Serin-Protease Furin, das latent TGF-[beta] binding protein-1 und Polymorphismen der TGF-[beta]1-Signalsequenz in vitro
… the first part of this thesis, the influence of TGF-beta1 polymorphisms at position –509, codon 10, codon 25 and codon 263 on hepatitis C induced liver fibrosis was analysed. For that purpose, liver needle biopsies from 430 patients suffering from chronic hepatitis C infection were scored for the …
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Controlled growth factor delivery from biodegradable hydrogel scaffolds for articular cartilage repair
… examined release of transforming growth factor-beta1 (TGF-beta1) directly from OPF hydrogels and also from gelatin microparticles encapsulated within these OPF networks. These studies showed that hydrogel mesh size and microparticle content can be altered to control growth factor release rates. …
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Assoziation zwischen vier Polymorphismen des menschlichen Transforming-Growth-Factor-beta1-Gens und der zeitlichen Progression der posthepatitischen Leberfibrose
… relationships between four polymorphisms of the TGF-beta1 gene (-800G>A; -509C>T; Leu10Pro; Arg25Pro) and stage, histological activity grade and progression rate (METAVIR-score) of liver fibrosis. Methods: Three study groups, i.e. 48 patients with hepatic fibrosis (26 with known duration of …
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The potential role of innate immunity in the pathogenesis of post-operative adhesions
… basal levels of adhesion phenotype markers: TGF-beta1, VEGF, and type I collagen. Hypoxia enhances the expression of TGF-beta1, VEGF, and type I collagen through a HIF-1alpha and TGF-beta1 dependent mechanism. Additionally, macrophages exposed to hypoxia release specific factors that are …
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Unterschiede in der TGF-[beta]-vermittelten Signaltransduktion in aktivierten hepatischen Sternzellen unterhalb der Smad2-Phosphorylierung
TGF-beta is a multifunctional cytokine, that regulates cell proliferation, differentiation, and extracellular matrix production. A profibrogenic role of TGF-beta is postulated, but pathways targeting the TGF-beta response to specific gene activities involved in phenotypic changes of hepatic …
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TGF-beta Activated Kinase-1 (TAK1) Is a Critical Prostate Tumor Suppressor
TGF-beta activated kinase-1 (TAK1) encoded by the MAP3K7 gene is a serine/threonine protein kinase that functions in the regulation of cell proliferation, apoptosis, differentiation and/or inflammation. Genetic studies have shown that hemizygous deletion of the MAP3K7 gene is frequent (32%) in …
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Post-translational processing of proteins implicated in the pathogenesis of Alzheimer's disease.
… of AD.The cytokine transforming growth factor-beta1 (TGF-beta1) is upregulated in AD brains, but its mRNA expression has not been characterised. TGF-beta1 and hAPP(V717F) bigenicmice show accelerated development of AD-like pathology compared with hAPP(V717F) singly transgenic mice (Wyss-Coray …
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Studies of the PTEN tumour suppressor in endometrial cancer.
… reflects the menstrual cycle. The role of TGF-beta1 in PTEN expression of PTEN in human cells has been also investigated, but the results are contradictory. Compounds which stimulate up-regulation of PTEN represent potential anti-tumour therapies and therefore merit investigation. To …
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Transforming growth factor beta 1 : Role in the progression of chronic renal failure.
TGF-beta1 plays an important role in the pathogenesis of experimental and clinical glomerulosclerosis and tubufointerstitial fibrosis. Associations have been described between polymorphisms of cytokine and growth factor genes and susceptibility to, or progression of, an increasing number of …
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Modulation of cell morphology and function using synthetic biodegradable polymers
… bioactive molecules. Transforming growth factor-beta1 (TGF-beta1) was incorporated into microparticles of, blends of PLGA and poly(ethylene glycol) (PEG) as a model growth factor and released in vitro in buffer solutions simulating body fluids for up to 28 days. The release of TGF-beta1 was …
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TGF-beta 1 PATHWAY AND AGE-RELATED MACULAR DEGENERATION
… (Abeta) oligomers, and assess the effect of TGF-beta 1. Furthermore a topical formulation of transforming growth factor 1 (TGF-beta 1) was developed; and TGF-beta 1 ocular pharmacokinetics profile was assessed. Methods: Sprague-Dawley male rats were used. Human Abeta 1-42 oligomers were …
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Silencing of endoglin in rat hepatic stellate cells by RNA interference identifies endoglin as an important component of the transdifferentiation process
… development of fibrosis. Endoglin functions as a TGF-beta receptor and TGF-beta, on the other hand, is a key regulator that initiates and perpetuates the transdifferentiation process. This raises the questions whether endoglin has any impact on the transdifferentiation of HSC and whether endoglin …
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Effect of Implant Surface Microtopography by Hydroxyapatite Grit-Blasting on Adhesion, Proliferation and Differentiation of Osteoblast-like Cell Line, MG-63
… increased secretion of osteocalcin, osteopontin, TGF-beta1 and PGE2 which was known to stimulate the osteogenesis. Moreover, alizarin red-s staining revealed that there were significantly more mineralized nodules on RBM surfaces compared with machined discs. Conclusions: Our results demonstrated …
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MMP's, TIMP's, PIIINP und Hyaluronan im Serum und Gewebe von Patientinnen mit Kapselfibrose nach alloplastischer Mammaaugmentation
… inflammatory process and the induction of TGF-beta1 a cytokine involved in fibrogenesis. Histological there was a thicker capsule tissue correlating to Baker and inflammatory cells and refracting material and immunhistochemically a intensive stain for TIMP-1 and TIMP-2 and local for MMP-2. …
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Maternal Serum and Whey Immune Markers and Eczema Among Infants
… were used to assay transforming growth factor (TGF)-beta1 and immunoglobulin A (IgA). Eczema-like disorders were ascertained at ages 6 and 12 months by telephone interviews. Generalized estimating equations were used to estimate the effect of immune marker on repeated eczema information at ages …
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Optimizing a scaffoldless approach for cartilage tissue engineering
… to determine the effects of BMP-2, IGF-I, and TGF-beta1, alone and in combination, on the functional properties of engineered constructs. This was the first study to demonstrate significant increases in both compressive and tensile biomechanical properties as a result of growth factor …
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