Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"TGF-beta1"”.
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Evaluierung synergistischer Effekte von rhBMP-2-Mutanten und TGF-Beta1 bei der induzierten Knochenbildung : eine In-vivo-Studie in Ratten
… veränderte Mutanten T3 und T4, jeweils mit rhTGF-ß1 kombiniert. Das Ziel der Studie bestand darin, nachzuweisen, ob TGF-ß1 die osteoinduktive Potenz dieser BMPs steigert. Als Proteinkonzentrationen wurden 0,5µg und 1µg des jeweiligen Proteins gewählt. Des Weiteren wurde untersucht, ob rhTGF-ß1 …
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Controlled growth factor delivery from biodegradable hydrogel scaffolds for articular cartilage repair
… examined release of transforming growth factor-beta1 (TGF-beta1) directly from OPF hydrogels and also from gelatin microparticles encapsulated within these OPF networks. These studies showed that hydrogel mesh size and microparticle content can be altered to control growth factor release rates. …
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The potential role of innate immunity in the pathogenesis of post-operative adhesions
… basal levels of adhesion phenotype markers: TGF-beta1, VEGF, and type I collagen. Hypoxia enhances the expression of TGF-beta1, VEGF, and type I collagen through a HIF-1alpha and TGF-beta1 dependent mechanism. Additionally, macrophages exposed to hypoxia release specific factors that are …
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TGF-beta Activated Kinase-1 (TAK1) Is a Critical Prostate Tumor Suppressor
TGF-beta activated kinase-1 (TAK1) encoded by the MAP3K7 gene is a serine/threonine protein kinase that functions in the regulation of cell proliferation, apoptosis, differentiation and/or inflammation. Genetic studies have shown that hemizygous deletion of the MAP3K7 gene is frequent (32%) in …
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Post-translational processing of proteins implicated in the pathogenesis of Alzheimer's disease.
… of AD.The cytokine transforming growth factor-beta1 (TGF-beta1) is upregulated in AD brains, but its mRNA expression has not been characterised. TGF-beta1 and hAPP(V717F) bigenicmice show accelerated development of AD-like pathology compared with hAPP(V717F) singly transgenic mice (Wyss-Coray …
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Studies of the PTEN tumour suppressor in endometrial cancer.
… reflects the menstrual cycle. The role of TGF-beta1 in PTEN expression of PTEN in human cells has been also investigated, but the results are contradictory. Compounds which stimulate up-regulation of PTEN represent potential anti-tumour therapies and therefore merit investigation. To …
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Transforming growth factor beta 1 : Role in the progression of chronic renal failure.
TGF-beta1 plays an important role in the pathogenesis of experimental and clinical glomerulosclerosis and tubufointerstitial fibrosis. Associations have been described between polymorphisms of cytokine and growth factor genes and susceptibility to, or progression of, an increasing number of …
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Modulation of cell morphology and function using synthetic biodegradable polymers
… bioactive molecules. Transforming growth factor-beta1 (TGF-beta1) was incorporated into microparticles of, blends of PLGA and poly(ethylene glycol) (PEG) as a model growth factor and released in vitro in buffer solutions simulating body fluids for up to 28 days. The release of TGF-beta1 was …
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TGF-beta 1 PATHWAY AND AGE-RELATED MACULAR DEGENERATION
… (Abeta) oligomers, and assess the effect of TGF-beta 1. Furthermore a topical formulation of transforming growth factor 1 (TGF-beta 1) was developed; and TGF-beta 1 ocular pharmacokinetics profile was assessed. Methods: Sprague-Dawley male rats were used. Human Abeta 1-42 oligomers were …
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Effect of Implant Surface Microtopography by Hydroxyapatite Grit-Blasting on Adhesion, Proliferation and Differentiation of Osteoblast-like Cell Line, MG-63
… increased secretion of osteocalcin, osteopontin, TGF-beta1 and PGE2 which was known to stimulate the osteogenesis. Moreover, alizarin red-s staining revealed that there were significantly more mineralized nodules on RBM surfaces compared with machined discs. Conclusions: Our results demonstrated …
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Maternal Serum and Whey Immune Markers and Eczema Among Infants
… were used to assay transforming growth factor (TGF)-beta1 and immunoglobulin A (IgA). Eczema-like disorders were ascertained at ages 6 and 12 months by telephone interviews. Generalized estimating equations were used to estimate the effect of immune marker on repeated eczema information at ages …
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Optimizing a scaffoldless approach for cartilage tissue engineering
… to determine the effects of BMP-2, IGF-I, and TGF-beta1, alone and in combination, on the functional properties of engineered constructs. This was the first study to demonstrate significant increases in both compressive and tensile biomechanical properties as a result of growth factor …
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Novel Immunotherapies and Immunoregulation in a Chronic Inflammatory Disease of the Central Nervous System
… T cell cytokine responses and enhancing TGF-beta1 production in the CNS. In another study, we investigated the therapeutic potential of monoclonal antibody (H57-597 mAb) against the T cell receptor (TCR) alpha/beta. We demonstrated that short term administration of anti-TCR alpha/beta can …
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Runx1 in Primitive Hematopoiesis and Characterization of Hematopoietic Stem Cells in a Mouse Chronic Inflammatory Arthritis Model
… of primitive hematopoiesis by Runx1 and TGF-beta signaling.<underline> Primitive hematopoiesis, occurring exclusively in the yolk sac, is characterized by its transient nature. As the primitive hematopoiesis declines in the yolk sac, definitive hematopoietic progenitors generated in the …
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Reduction of tumorigenesis in androgen receptor overexpressed Huh7 cells through TGF-β induced cellular senescence phenotypes
… in the cell culture system with or without DHT, TGF-beta1 mRNA expression was increased in the Huh7-AR cells and HCC tumors in the presence of DHT. At the same time, secretion of TGF-beta 1 was significantly higher in the Huh7-AR cells than that in Huh7-V cells. The effect of TGF-beta 1 on the …
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The Role of Astrocyte-Derived Factors in the Regulation of Multidrug Resistance at the Developing Blood-Brain Barrier
… effect of transforming growth factor-beta1 (TGF-β1), a growth factor secreted by astrocytes in late gestation, on P-gp at the BBB. This effect was attenuated as gestation progressed. During this time in pregnancy, it is common for women to receive synthetic glucocorticoids (sGC). This …