Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"TGF-B"”.
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The Role of TGF-B Activated Kinase (TAK1) in Retinal Development and Inflammation
Transforming growth factor β-activated kinase 1 (TAK1), a hub kinase at the convergence of multiple signaling pathways, is critical to the development of the central nervous system and has been found to play a role in cell death and apoptosis. TAK1 may have the potential to elucidate mechanisms of …
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IL-2 and Antisense TGF-B1 Gene Therapy of the H238 Tumor and Analysis of TGF-B Receptors
<p>Transforming growth factor-beta (TGF-p) belongs to a family of immunosuppressive cytokines, capable of regulating macrophages, T, B and NK cells. We have detected the TGF-p transcript being synthesized by H238 cells. This is herpes simplex-Type2 transformed murine fibrosarcoma cell line. The …
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The Role and Mechanism of The Homeobox Gene Dlx4 In Transforming Growth Factor-B Resistance In Cancer
<p>Transforming growth factor-b (TGF-b) is a cytokine that plays essential roles in regulating embryonic development and tissue homeostasis. In normal cells, TGF-b exerts an anti-proliferative effect. TGF-b inhibits cell growth by controlling a cytostatic program that includes activation of the …
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Signal transduction of transforming growth factor-Beta in cytotoxic T cells
Transforming-Growth-Factor-beta1 (TGF-b1) ist ein multifunktionelles Zytokin, welches insbesondere Zellwachstum und Zelldifferenzierung koordiniert. TGF-b ist vor allem dafür bekannt, Zellen des Immunsystems zu beeinflussen. TGF-b steuert zum Beispiel die Differenzierung von T-Zellen und und deren …
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Regulation of TIM-3 Expression in Mast cells and Monocytes
… in HMC-1 cell was upregulated only by TGF-b but not by IFN-a, IFN-l, TNF-a, IL-10, LPS or FcεR cross-linking. Whereas transcription of TIM-3 ligand, galectin-9 was not affected by treatment with TGF-b. To reveal downstream pathway of TGF-b stimulation involved in TIM-3 upregulation in …
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Molecular Mechanisms Underlying The Transcriptional Regulation of T Helper 17 and Regulatory T Cells
… reciprocally regulated since they both require TGF-b for their development. We investigated the role of the Treg-associated master transcription factor Foxp3, and found that Foxp3 inhibits Th17 cell generation by preventing the transcriptional activity of the two main Th17-specific transcription …
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Synovial Fibrosis in Osteoarthritis of the Knee: Mechanism of Development and Potential Therapeutic Targets
… fiber formation. Transforming growth factor-β (TGF-b) plays an important role in mediating the pathogenesis of synovial fibrosis. Synoviocytes produce proteoglycan-4 (PRG4; lubricin), a heavily glycosylated mucinous glycoprotein, and hyaluronic acid (HA). Both PRG4 and HA compete for binding to …
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Einfluss von BMP-7 und Endoglin auf den TGF-beta Signalweg bei fibrosierenden Lebererkrankungen
… was to analyze the influence of BMP-7 on the TGF-b1 pathway and to characterize the role of endoglin within these two pathways. Using the endoglin deficient myoblast cell line L6E9 it was possible to show the antagonistic character of these two cytokines and further to determine their …
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Lösliches Endoglin (sCD105) : diagnostische Wertigkeit bei chronischen Lebererkrankungen und funktionelle Bedeutung für die Signaltransduction von transforming growth factor (TGF-beta)
… of heterologously expressed soluble endoglin on TGF-b1/Smad3 signaling by using an artificial reporter system for the detection of phosphorylated Smad3, i.e. (CAGA)12-MLP Luc. For the evaluation of sCD105 as a marker for the occurence of HCC in high-risk patients, we measured the concentration of …
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Role of biological mediators in periodontal healing responses
… the healing process, such as interleukins, PDGF, TGF-b, IGF- 1, FGF-2, VEGF, and EGF. Non-coding RNAs have been found to be associated with inflammatory reactions including periodontal diseases. The important functions of cytokines and the gene expression levels in regulating PDL cells has given …
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Modeling Post Stroke Respiratory Dysfunction, Apneas and Cognitive Decline
… underwent intracerebroventricular injections of TGF-b. Suggesting the TGF-b signaling pathway contributes to the onset of astrogliosis and respiratory dysfunction.</p> <p>Our data suggests that stroke disrupts basal breathing rather than increasing chemoreceptor gain. Therefore, we predict …
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Untersuchungen über die Interaktion von Meningokokken mit Zellen der Blut-Hirn-Schranke
… und transformierendem Wachstumsfaktor beta (TGF-b) durch Gehirnendothelzellen nach Infektion mit Meningokokken analysiert. Mit ELISA und RT-PCR wurde die Freisetzung von Zytokinen und die Transkription der Zytokin-codierenden Gene von humanen Gehirnendothelzellen (HBMEC) nach Infektion mit …
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CHARACTERIZATION OF CD4+ T CELL-INDUCING EPITOPES OF ISLETSPECIFIC GLUCOSE-6-PHOSPHATASE CATALYTIC SUBUNIT-RELATED PROTEIN (IGRP) THAT PREVENT AUTOIMMUNITY
… protect against T1D development via IL-10 and TGF-B production. The ability to induce regulatory T cells makes IGRP peptides P3 and P7 attractive targets for diabetes therapy and prevention.
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The characterisation of dendritic cell, microglial, macrophage and T cell responses during mycobacterial infection of the central nervous system
… a higher frequency of polyfunctional IFNg+TGF-b+CD4+ T cells than IFNg+TGF-b+IL-10+CD4+ T cells. M. tuberculosis-infected DCs from CLNs of CNS-TB mice were cocultured with naïve CD3+ T cells to generate a DC-T cell coculture, cells were sorted using fluorescence-activated cell sorting …
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Selenoprotein P in der kolorektalen Karzinogenese
… ergab eine negative Regulierung durch TGF b, welches in Kolonkarzinomen verstärkt nachgewiesen wurde und eine mögliche Erklärung für die verminderte Expression sein könnte neben anderen regulatorischen Einflüssen.
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Engineering B Cells For Use In Immunotherapy and Cancer
… IL-35 and transforming growth factor-beta (TGF-b). Ex vivo expansion of B cells has been challenging due to their tendency to undergo apoptosis in culture. Thus, creating a successful expansion protocol with exceptional viability will open the door for B cells to be used directly for …
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Tumor-Bearing Host Macrophage Dysfunction: Role of CD40/CD40L Interactions
… is impaired in TBH Mfs due to tumor cell-derived TGF-b and, to a lesser extent, IL-10. ICSBP induces CD40L, IL-12, and IL-18 expression. Disruption of the CD40/CD40L interaction via lowered CD40L expression generates an immunosuppressive loop that may be a strategy for tumor survival and growth. …
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Precision Medicine in Immunotherapy and Lung Cancer
… markers for Activin-A, GDF-11 and TGF-B as potential predictive biomarkers for platinum-based chemotherapy within two populations – a retrospective cohort from Westmead Hospital and a prospectively-collected biobank (EnRICH) across New South Wales. The second and third chapters …
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The role of the wingless gene in the control of growth and pattern formation during drosophila wing development
… (Dpp, a secreted signalling molecule of the TGF-B family) is the mediator of the A/P organizer, while Wingless (DWnt-l, a secreted molecule of the Wnt family) is a key mediator of the D/V organizer. In this thesis, several aspects of Wingless function in the wing imaginal disc are examined. …
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Immune Modulation of The Mycobacterium Tuberculosis Granulomatous Response
… response, accompanied by increased IL-10 and TGF-b production. Finally, the ability of lactoferrin to serve as a novel therapeutic for the treatment of TB was performed by aerosol challenging mice with MTB and treating them with lactoferrin added to the drinking water. Mice given tap water had …
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