Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 30 for “"TGF-B"”.
-
The Role of TGF-B Activated Kinase (TAK1) in Retinal Development and Inflammation
Transforming growth factor β-activated kinase 1 (TAK1), a hub kinase at the convergence of multiple signaling pathways, is critical to the development of the central nervous system and has been found to play a role in cell death and apoptosis. TAK1 may have the potential to elucidate mechanisms of …
-
IL-2 and Antisense TGF-B1 Gene Therapy of the H238 Tumor and Analysis of TGF-B Receptors
<p>Transforming growth factor-beta (TGF-p) belongs to a family of immunosuppressive cytokines, capable of regulating macrophages, T, B and NK cells. We have detected the TGF-p transcript being synthesized by H238 cells. This is herpes simplex-Type2 transformed murine fibrosarcoma cell line. The …
-
The Role and Mechanism of The Homeobox Gene Dlx4 In Transforming Growth Factor-B Resistance In Cancer
<p>Transforming growth factor-b (TGF-b) is a cytokine that plays essential roles in regulating embryonic development and tissue homeostasis. In normal cells, TGF-b exerts an anti-proliferative effect. TGF-b inhibits cell growth by controlling a cytostatic program that includes activation of the …
-
Signal transduction of transforming growth factor-Beta in cytotoxic T cells
Transforming-Growth-Factor-beta1 (TGF-b1) ist ein multifunktionelles Zytokin, welches insbesondere Zellwachstum und Zelldifferenzierung koordiniert. TGF-b ist vor allem dafür bekannt, Zellen des Immunsystems zu beeinflussen. TGF-b steuert zum Beispiel die Differenzierung von T-Zellen und und deren …
-
Regulation of TIM-3 Expression in Mast cells and Monocytes
… in HMC-1 cell was upregulated only by TGF-b but not by IFN-a, IFN-l, TNF-a, IL-10, LPS or FcεR cross-linking. Whereas transcription of TIM-3 ligand, galectin-9 was not affected by treatment with TGF-b. To reveal downstream pathway of TGF-b stimulation involved in TIM-3 upregulation in …
-
Molecular Mechanisms Underlying The Transcriptional Regulation of T Helper 17 and Regulatory T Cells
… reciprocally regulated since they both require TGF-b for their development. We investigated the role of the Treg-associated master transcription factor Foxp3, and found that Foxp3 inhibits Th17 cell generation by preventing the transcriptional activity of the two main Th17-specific transcription …
-
Synovial Fibrosis in Osteoarthritis of the Knee: Mechanism of Development and Potential Therapeutic Targets
… fiber formation. Transforming growth factor-β (TGF-b) plays an important role in mediating the pathogenesis of synovial fibrosis. Synoviocytes produce proteoglycan-4 (PRG4; lubricin), a heavily glycosylated mucinous glycoprotein, and hyaluronic acid (HA). Both PRG4 and HA compete for binding to …
-
Role of biological mediators in periodontal healing responses
… the healing process, such as interleukins, PDGF, TGF-b, IGF- 1, FGF-2, VEGF, and EGF. Non-coding RNAs have been found to be associated with inflammatory reactions including periodontal diseases. The important functions of cytokines and the gene expression levels in regulating PDL cells has given …
-
Modeling Post Stroke Respiratory Dysfunction, Apneas and Cognitive Decline
… underwent intracerebroventricular injections of TGF-b. Suggesting the TGF-b signaling pathway contributes to the onset of astrogliosis and respiratory dysfunction.</p> <p>Our data suggests that stroke disrupts basal breathing rather than increasing chemoreceptor gain. Therefore, we predict …
-
Untersuchungen über die Interaktion von Meningokokken mit Zellen der Blut-Hirn-Schranke
… und transformierendem Wachstumsfaktor beta (TGF-b) durch Gehirnendothelzellen nach Infektion mit Meningokokken analysiert. Mit ELISA und RT-PCR wurde die Freisetzung von Zytokinen und die Transkription der Zytokin-codierenden Gene von humanen Gehirnendothelzellen (HBMEC) nach Infektion mit …
-
CHARACTERIZATION OF CD4+ T CELL-INDUCING EPITOPES OF ISLETSPECIFIC GLUCOSE-6-PHOSPHATASE CATALYTIC SUBUNIT-RELATED PROTEIN (IGRP) THAT PREVENT AUTOIMMUNITY
… protect against T1D development via IL-10 and TGF-B production. The ability to induce regulatory T cells makes IGRP peptides P3 and P7 attractive targets for diabetes therapy and prevention.
-
The characterisation of dendritic cell, microglial, macrophage and T cell responses during mycobacterial infection of the central nervous system
… a higher frequency of polyfunctional IFNg+TGF-b+CD4+ T cells than IFNg+TGF-b+IL-10+CD4+ T cells. M. tuberculosis-infected DCs from CLNs of CNS-TB mice were cocultured with naïve CD3+ T cells to generate a DC-T cell coculture, cells were sorted using fluorescence-activated cell sorting …
-
Selenoprotein P in der kolorektalen Karzinogenese
… ergab eine negative Regulierung durch TGF b, welches in Kolonkarzinomen verstärkt nachgewiesen wurde und eine mögliche Erklärung für die verminderte Expression sein könnte neben anderen regulatorischen Einflüssen.
-
Engineering B Cells For Use In Immunotherapy and Cancer
… IL-35 and transforming growth factor-beta (TGF-b). Ex vivo expansion of B cells has been challenging due to their tendency to undergo apoptosis in culture. Thus, creating a successful expansion protocol with exceptional viability will open the door for B cells to be used directly for …
-
Tumor-Bearing Host Macrophage Dysfunction: Role of CD40/CD40L Interactions
… is impaired in TBH Mfs due to tumor cell-derived TGF-b and, to a lesser extent, IL-10. ICSBP induces CD40L, IL-12, and IL-18 expression. Disruption of the CD40/CD40L interaction via lowered CD40L expression generates an immunosuppressive loop that may be a strategy for tumor survival and growth. …
-
Precision Medicine in Immunotherapy and Lung Cancer
… markers for Activin-A, GDF-11 and TGF-B as potential predictive biomarkers for platinum-based chemotherapy within two populations – a retrospective cohort from Westmead Hospital and a prospectively-collected biobank (EnRICH) across New South Wales. The second and third chapters …
-
The role of the wingless gene in the control of growth and pattern formation during drosophila wing development
… (Dpp, a secreted signalling molecule of the TGF-B family) is the mediator of the A/P organizer, while Wingless (DWnt-l, a secreted molecule of the Wnt family) is a key mediator of the D/V organizer. In this thesis, several aspects of Wingless function in the wing imaginal disc are examined. …
-
Immune Modulation of The Mycobacterium Tuberculosis Granulomatous Response
… response, accompanied by increased IL-10 and TGF-b production. Finally, the ability of lactoferrin to serve as a novel therapeutic for the treatment of TB was performed by aerosol challenging mice with MTB and treating them with lactoferrin added to the drinking water. Mice given tap water had …
-
THE ROLE OF OMEGA 3 FATTY ACIDS IN CAPSULAR CONTRACTURE AROUND THE BREAST IMPLANTS
… contraction, evaluating the thickness, and tgfb expression on sample of capsule collected in a rat living model. Materials and Methods:32 Wild-type C57BL/6 knockout mice were bred and maintained in a university vivarium.The animals were divided in two groups: Omega3/control. Mice were …
-
Toll Like Receptor Dependent Control of T Helper 17 Cell Differentiation and Inflammasome Activation
… critical for Th1 lineage development, IL-6 and TGF-b play an important role in differentiation of Th17 cells in vitro. IL-1 has also been implicated in regulating Th17 differentiation. In this dissertation, we examined the relative contribution of IL-6 and IL-1 for in vivo Th17 differentiation, …
Page 1 of 2