Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 96 for “"TGF-β1"”.
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TGF-β1-induced Chloride Channel Activity and Migration of Human Eosinophils
… and cytokines. Transforming growth factor (TGF)-β also induces asthmatic features in the lungs, especially airway remodeling. Eosinophils and TGF-β are closely linked to each other in the induction of airway remodeling. TGF-β activity also affects chloride channel activity, which can …
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Il TGF-β1 come nuovo target farmacologico nella depressione e nella malattia di Alzheimer
… e una compromissione della neurotrofina TGF-β1 esercita un ruolo chiave soprattutto nella fisiopatologia dei deficit cognitivi associati a queste malattie. Gli antidepressivi di seconda generazione, in particolare gli inibitori selettivi della ricaptazione della serotonina (SSRI), sono …
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Regulation of Murine Mast Cell Homeostasis by TGF-β1 and CD4+CD25+C Regulatory T Cells
… cytokines, including transforming growth factor β1 (TGF- β1). TGF- β1 has many cellular sources, one of which is CD4+CD25 regulatory T cells (Tregs). We wanted to determine the effects of Transforming Growth Factor (TGF) βl on mast cell development. We find that TGFβl decreased FcεRI, c-Kit, …
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The Effect of Radiation and Repeated Sub-culturing on TGF-β1 Signaling in FRTL-5 Cells
… following radiation exposure. We determined that TGF-β1 production increased under both conditions. We hypothesized that alteration in the TGF-β1 signaling pathway contributed to the changes observed in the cellular properties of FRTL-5 cells. Our objective was to examine some of the players in …
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Characterization and modeling of cell activation upon TGF-β1 stimulation in a 3-D culture system
… and applied transforming growth factor-beta1 (TGF-β1) on the top of the 3-D culture to induce the conversion from normal fibroblasts to myofibroblasts and expression of a marker protein, alpha-smooth muscle actin (α-SMA). The cell response with TGF-β1 stimulation was captured with …
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Cullin 4B Ubiquitin Ligase Is Important for Cell Survival and Regulates TGF-β1 Expression in Pleural Mesothelioma
… of Hippo pathway genes including YAP1, CTGF, and survivin. Interestingly, CUL4B and not CUL4A knockdown reduced TGF-β1 and MMP2 expression, suggesting a unique association of CUL4B with this pathway. However, the treatment of PM cells with exogenous TGF-β1 following CUL4B knockdown did …
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SREBP-1 and Cell Surface GRP78 are important modulators of TGF-β1 in the progression of diabetic nephropathy
… nearby cell types. Transforming growth factor (TGF)-β1 is a cytokine that mesangial cells secrete, and has been identified as a profibrotic factor during the pathogenesis of diabetic nephropathy. Concerns have been raised in the use of direct anti-TGF-β1 therapy due to adverse events (such as …
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Role of Extracellular Signal-Regulated Kinase and Peroxisome Proliferator-Activated Receptor gamma on Transforming Growth Factor-β1-Induced Human Endometrial Stromal Cell Decidualization
… To investigate the role of ERK and PPAR gamma on TGF-β1-induced human endometrial stromal cell decidualization in vitro. MATERIALS AND METHODS: Human endometrial tissues obtained by hysterectomy specimens from patients with conditions other than endometrial diseases such as leiomyoma. Endometrial …
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Snail1-mediated Gene Repression Links EMT to Enhanced Biliary Epithelial Cell Survival and Lung Epithelial Cancer Cell Migration
… we utilized transforming growth factor-beta 1 (TGF-β1) to establish EMT in non-malignant murine biliary epithelial cells (cholangiocytes, 603B cells) and human lung epithelial carcinoma cells (A495 cells). We examined collagen production and cell survival in 603B cells and cell migration in A549 …
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Chronic kidney disease in HIV populations: prevalence, risk factors and role of transforming growth factor beta (TGF-߀1) polymorphisms
… of urinary transforming growth factor-beta-1 (TGF-β1) for CKD in the HIV population and determine the association between polymorphisms of TGF-β1 gene and prevalent CKD. Methods: A meta-analysis was performed to document the prevalence of CKD in the global HIV population. From the local HIV …
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Involvement of mitochondrial dysfunction during transforming growth factor β1-induced senescence-like growth arrest of MvlLu cells
… to oxidative damage. Transforming growth factor β1 (TGF β1) has well been known to suppress epithelial cell growth and recently been described to be involved in cellular senescence. The purpose of this study is to investigate how TGF β1 could induce senescence in Mv1Lu mink lung epithelial cells, …
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The epithelial-mesenchymal transition of hepatocyte in liver cirrhosis
… Incubation of primary rat hepatocytes with TGF-β1, the central cytokine in fibrogenesis, and hepatocytes isolated from fibrotic rat liver showed decrease of epithelial cell markers such as c-Met, cytokeratin18 and zonula occludens-1 (ZO-1) in contrast to the increase of mesenchymal cell …
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NEU Insights and Development of Potential Therapeutics for Pulmonary Fibrosis
… signals such as transforming growth factor-β1 (TGF-β1) and interleukin (IL)-6 upregulate NEU3 in a variety of human lung cells. Conversely, recombinant human NEU3 upregulates extracellular accumulation of active TGF-β1 and upregulates IL-6 in human peripheral blood mononuclear cells (PBMC). …
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Molecular cell cycle mechanisms of human prostate crcinoma insensitivity to TGF-β?
TGF-β is a potent growth inhibitor of epithelial cells. However, many transformed cells have lost their sensitivity to this growth inhibitory effect. The molecular mechanism of such insensitivity is not yet understood. Here, we have studied the TGF-β1 effect on normal human prostate and carcinoma …
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Investigating the functionality of African-specific variants in the TGFB1 regulatory region and their potential role in HIV-associated kidney complications
Transforming growth factor beta-1 (TGF-β1) is a cytokine involved in immune modulation and tissue regeneration and has a polymorphic TGFB1 promoter. African-specific single nucleotide polymorphisms (SNPs) have been identified in the TGFB1 promoter and they occur at higher frequencies in South …
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Effect of Anti-fibrotic Drug (Pirfenidone) on TGF-β Signaling Pathway in Ocular Fibrotic Disorders
Purpose: Transforming growth factor-β (TGF-β) plays a key role in transforming retinal pigment epithelial (RPE) cells into mesenchymal fibroblastic cells, which are implicated in fibrotic disorders of the retina. Herein, the effect of pirfenidone, a novel anti-fibrotic agent, on TGF-β1-mediated …
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