Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 184 for “"TGF-β"”.
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Endometrial Decidualization by TGF-β and PPAR-γ
… pregnancy, so we investigated the interaction of TGF-β and PPAR-γ on decidualization using cultured human endometrial stromal cell. METHODS: Human endometrial tissues were examined immunohistochemically for the expression of TGF-β receptors and transducer proteins in the TGF-β signaling. And we …
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Molecular insights into signalling mechanisms within TGF-β superfamily
The TGF-β superfamily includes receptors, extracellular signalling molecules, their inhibitors and intracellular downstream signalling components. Members of the superfamily are present in all metazoans, expressed in all cells of the body and they are involved in embryonic development, adult tissue …
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The effect of EGFL7 on the TGF-β/BMP family
… í fylgjunni en sýnt hefur verið fram á að TGF-β fjölskyldan komi meðal annars að stjórnun æðamyndunar. Einnig hefur verið sýnt fram á að TSP-1 hindri æðamyndun í æðaþelsfrumum og að æðaþelspróteinið EGFL7 geti leitt til aukins frumuskriðs í fylgjumyndun. Takmörkuð þekking er á …
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Effects of TGF-β Inhibitor on Chemoresistance in Ovarian Cancer Models
… High levels of Transforming Growth Factor-β (TGF-β) was linked to poor prognosis, chemoresistance and metastasis risk in HGSC. Mechanisms include roles of TGF-β promoting epithelial to mesenchymal transition (EMT) and immune evasion via suppression of Granzyme B (Gzmb) and Perforin (Prf1) …
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Untersuchungen zu Bedeutung von TGF-β während der Entwicklung des Vorderhirns
Die transformierenden Wachstumsfaktoren β (TGF-βs) sind multifunktionale Zytokine, die zahlreiche zelluläre Prozesse in einer kontextabhängigen Weise regulieren können. TGF-βs und ihre Signaleffektoren sind im Vorderhirn exprimiert, über die Funktion von TGF-βs während der Entwicklung des …
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Role of Type III TGF-β Receptor Shedding in Regulating Tumorigenesis
<p>The type III TGF-β receptor (TβRIII) is a TGF-β co-receptor that presents ligand to the type II TGF-β receptor to initiate signaling. TβRIII also undergoes ectodomain shedding to release a soluble form (sTβRIII) that can bind ligand, sequestering it away from cell surface receptors. We have …
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A Study of TGF‐β Signaling in B Lymphocytes and Glioblastoma
<p>Transforming growth factor–β (TGF–β) signaling regulates a range of processes in a variety of cell types. Consequently, TGF–β plays a complex role in the progression of several types of cancers; it acts as a tumor suppressor in normal cells and early in tumor progression, yet it can promote …
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Molecular cell cycle mechanisms of human prostate crcinoma insensitivity to TGF-β?
TGF-β is a potent growth inhibitor of epithelial cells. However, many transformed cells have lost their sensitivity to this growth inhibitory effect. The molecular mechanism of such insensitivity is not yet understood. Here, we have studied the TGF-β1 effect on normal human prostate and carcinoma …
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The Role of TGF-β in CTB-Insulin Regulated Human Dendritic Cell Tolerance
… studies suggest transforming growth factor beta (TGF-β) may play a role in the stimulation of IDO1 biosynthesis for induction of immunological tolerance in murine DCs. To elucidate the mechanisms by which CTB-INS may stimulate IDO1 biosynthesis and mediate tolerance in human DCs, we investigated …
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Die Rolle von transformierenden Wachstumsfaktoren-beta (TGF-β) in der Entwicklung von Synapsen
Die transformierenden Wachstumsfaktoren-beta (TGF-β) stellen eine Superfamilie von Proteinen dar, die in der Entwicklung und Differenzierung des Nervensystems unterschiedlichste Funktionen erfüllen. Ihre Rolle in der Synaptogenese in Säugetieren ist jedoch bislang nur teilweise untersucht und …
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Interrogating the molecular mechanism of signal transduction in the TGF-β receptor superfamily
… cascade to achieve a physiological response. TGF-β signalling is central to many physiological processes, from embryonic development to adult tissue homeostasis and immune responses. Over 30 dimeric growth factor ligands compete for binding to 7 type I receptors and 5 type II receptors, with …
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Expression cloning and characterization of the type II and type III TGF-β receptors
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1993.
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The study of tumor-derived Smad4 mutations in transforming growth factor β (TGF-β) signaling
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Investigating a co-operative link between TGF-β and Lyn kinase in Chronic Myeloid Leukaemia
… whether transforming growth factor-β (TGF) might influence drug-resistance through direct affects on Lyn kinase levels and its activation. This research builds on previous findings of Bcr-Abl-dependent up-regulation of TGFβ signalling, implicating this cytokine in CML. Human MYL cell …
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Effect of Anti-fibrotic Drug (Pirfenidone) on TGF-β Signaling Pathway in Ocular Fibrotic Disorders
Purpose: Transforming growth factor-β (TGF-β) plays a key role in transforming retinal pigment epithelial (RPE) cells into mesenchymal fibroblastic cells, which are implicated in fibrotic disorders of the retina. Herein, the effect of pirfenidone, a novel anti-fibrotic agent, on TGF-β1-mediated …
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Coordinated Blockade of TGF-β and PD-L1 Promotes Anti-Tumor Immunity in Ovarian Cancer Models
… Resistance to immunotherapy is driven in part by TGF-β signaling in the ovarian TIME, leading to immune suppression, metastasis, and development of malignant ascites. Bintrafusp alfa (BA) is a bifunctional fusion protein designed to simultaneously block TGF-β and PD-L1 pathway signaling by …
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Therapeutic Targeting of BMP and TGF-β Signalling Pathways for the Resolution of Pulmonary Arterial Hypertension
… which perturbs the balance between BMP and TGF-β pathways leading to the clinical course of the disease. Current therapies were discovered prior to the knowledge that PAH has substantial genetic components. Hence, this study aims to identify novel therapeutic intervention and provide novel …
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Reduction of tumorigenesis in androgen receptor overexpressed Huh7 cells through TGF-β induced cellular senescence phenotypes
… in the cell culture system with or without DHT, TGF-beta1 mRNA expression was increased in the Huh7-AR cells and HCC tumors in the presence of DHT. At the same time, secretion of TGF-beta 1 was significantly higher in the Huh7-AR cells than that in Huh7-V cells. The effect of TGF-beta 1 on the …
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The effects of TGF-β on the behaviour of a keratinocyte cell line: implications in wound repair
TGF-β isoforms are important signalling molecules in wound repair in the skin. Transforming growth factor β3 (TGF-β3) has been implicated in scarless healing. In both animal and human models the application of exogenous TGF-β3 causes a reduction in the inflammatory response and improves the …
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Developing a co-culture model of ovarian cancer to identify immunotherapies that can overcome TGF-β-induced immunosuppression
… (TME), notably transforming growth factor beta (TGF-β). TGF-β suppresses anti-tumor immunity, including the expression of granzyme B (GzmB) and other cytolytic effectors in CD8+ T cells. To address this challenge, we established a simplified co-culture model of the HGSC TME to test …
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