Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 597 for “"TGF-¿¿"”.
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IL-2 and Antisense TGF-B1 Gene Therapy of the H238 Tumor and Analysis of TGF-B Receptors
<p>Transforming growth factor-beta (TGF-p) belongs to a family of immunosuppressive cytokines, capable of regulating macrophages, T, B and NK cells. We have detected the TGF-p transcript being synthesized by H238 cells. This is herpes simplex-Type2 transformed murine fibrosarcoma cell line. The …
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TGF-beta signaling at the cellular junctions
… I have studied transforming growth factor-beta (TGF-beta) signal from the secreting to the receiving cells in the developing wing epithelial cells and at the neuromuscular junctions. Cell culture studies have suggested that cells modulate morphogenetic signaling by expressing the receptors and …
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Involvement of TGF-beta in skin photoaging
… this thesis study was to understand the role of TGF-[beta] in skin photoaging, especially in solar elastosis. Solar elastosis, the accumulation of elastotic material in the dermal extracelluar matrix, is a major hallmark of photoaging. However, the mechanisms by which UV radiation causes solar …
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TGF-beta und Empfindlichkeit für NO-abhängige Apoptose
… apoptotischen Zelltod induzieren. Dabei spielt TGF-beta eine zentrale Rolle. 48-stündige Einwirkung von TGF-beta auf nicht-transformierte NRK-Fibroblasten steigert deren normalerweise niedrige Empfindlichkeit gegenüber NO. 208 F Fibroblasten lassen sich nicht gegenüber der Apoptoseinduktion …
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Endometrial Decidualization by TGF-β and PPAR-γ
… pregnancy, so we investigated the interaction of TGF-β and PPAR-γ on decidualization using cultured human endometrial stromal cell. METHODS: Human endometrial tissues were examined immunohistochemically for the expression of TGF-β receptors and transducer proteins in the TGF-β signaling. And we …
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Einfluss von Transforming Growth Factor-beta1 (TGF-[beta]1) Genpolymorphismen auf die Hepatitis-C-induzierte Leberfibrose in vivo und Modulation der TGF-[beta]1-Synthese, Prozessierung und Sekretion durch die Serin-Protease Furin, das latent TGF-[beta] binding protein-1 und Polymorphismen der TGF-[beta]1-Signalsequenz in vitro
… the first part of this thesis, the influence of TGF-beta1 polymorphisms at position –509, codon 10, codon 25 and codon 263 on hepatitis C induced liver fibrosis was analysed. For that purpose, liver needle biopsies from 430 patients suffering from chronic hepatitis C infection were scored for the …
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Andstæð hlutverk TGF-ß fjölskyldunnar í fylgjumyndun og meðgöngueitrun
… þá leiði það til meðgöngueitrunar. Meðlimir TGF-ß fjölskyldunnar spila stórt hlutverk í fylgjumyndun og virðast þeir hafa bæði hindrandi eða örvandi áhrif á íferð næriþekjufrumna. ANGPTL4 er prótein sem tjáð er í fylgju en hlutverk þess í fylgjumyndun er óþekkt. Í brjóstakrabbameinsfrumum …
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TGF-beta 1 PATHWAY AND AGE-RELATED MACULAR DEGENERATION
… (Abeta) oligomers, and assess the effect of TGF-beta 1. Furthermore a topical formulation of transforming growth factor 1 (TGF-beta 1) was developed; and TGF-beta 1 ocular pharmacokinetics profile was assessed. Methods: Sprague-Dawley male rats were used. Human Abeta 1-42 oligomers were …
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Molecular insights into signalling mechanisms within TGF-β superfamily
The TGF-β superfamily includes receptors, extracellular signalling molecules, their inhibitors and intracellular downstream signalling components. Members of the superfamily are present in all metazoans, expressed in all cells of the body and they are involved in embryonic development, adult tissue …
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Knochenneubildung durch induktive Implantate der TGF-Beta-Familie : eine tierexperimentelle Studie zum Synergismus von BMP-2-Mutanten und TGF-Beta bei der heterotopen Osteoinduktion
… mit dem nicht osteoinduktiven Wachstumsfaktor rh-TGF-ß-1 zu steigern ist. Hierzu wurden zylinderförmige (Länge l=10mm, Durchmesser Ø=5mm), bovine EXKK-Träger (extrahiertes, xenogenes Knochen-Kollagen) mit den genannten BMPs, TGF-ß-1 und Kombinationen dieser Wachstumsfaktoren bestückt und für 28 …
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The effect of EGFL7 on the TGF-β/BMP family
… í fylgjunni en sýnt hefur verið fram á að TGF-β fjölskyldan komi meðal annars að stjórnun æðamyndunar. Einnig hefur verið sýnt fram á að TSP-1 hindri æðamyndun í æðaþelsfrumum og að æðaþelspróteinið EGFL7 geti leitt til aukins frumuskriðs í fylgjumyndun. Takmörkuð þekking er á …
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Untersuchungen zur TGF-[beta]1-Expression und -Bioverfügbarkeit bei der Leberfibrogenese
Transforming growth factor-Beta (TGF-Beta) is one of the most important cytokines mediating fibrogenesis in the liver and in other organs. The major portion of it is secreted as latent molecule complexed either only with the “latency associated peptide” (LAP) or with LAP and the “latent TGF-Beta …
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Effects of TGF-β Inhibitor on Chemoresistance in Ovarian Cancer Models
… High levels of Transforming Growth Factor-β (TGF-β) was linked to poor prognosis, chemoresistance and metastasis risk in HGSC. Mechanisms include roles of TGF-β promoting epithelial to mesenchymal transition (EMT) and immune evasion via suppression of Granzyme B (Gzmb) and Perforin (Prf1) …
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Untersuchungen zu Bedeutung von TGF-β während der Entwicklung des Vorderhirns
Die transformierenden Wachstumsfaktoren β (TGF-βs) sind multifunktionale Zytokine, die zahlreiche zelluläre Prozesse in einer kontextabhängigen Weise regulieren können. TGF-βs und ihre Signaleffektoren sind im Vorderhirn exprimiert, über die Funktion von TGF-βs während der Entwicklung des …
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