Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 535 for “"TGF-¿¿"”.
-
IL-2 and Antisense TGF-B1 Gene Therapy of the H238 Tumor and Analysis of TGF-B Receptors
<p>Transforming growth factor-beta (TGF-p) belongs to a family of immunosuppressive cytokines, capable of regulating macrophages, T, B and NK cells. We have detected the TGF-p transcript being synthesized by H238 cells. This is herpes simplex-Type2 transformed murine fibrosarcoma cell line. The …
-
TGF-beta signaling at the cellular junctions
… I have studied transforming growth factor-beta (TGF-beta) signal from the secreting to the receiving cells in the developing wing epithelial cells and at the neuromuscular junctions. Cell culture studies have suggested that cells modulate morphogenetic signaling by expressing the receptors and …
-
Involvement of TGF-beta in skin photoaging
… this thesis study was to understand the role of TGF-[beta] in skin photoaging, especially in solar elastosis. Solar elastosis, the accumulation of elastotic material in the dermal extracelluar matrix, is a major hallmark of photoaging. However, the mechanisms by which UV radiation causes solar …
-
TGF-beta und Empfindlichkeit für NO-abhängige Apoptose
… apoptotischen Zelltod induzieren. Dabei spielt TGF-beta eine zentrale Rolle. 48-stündige Einwirkung von TGF-beta auf nicht-transformierte NRK-Fibroblasten steigert deren normalerweise niedrige Empfindlichkeit gegenüber NO. 208 F Fibroblasten lassen sich nicht gegenüber der Apoptoseinduktion …
-
Endometrial Decidualization by TGF-β and PPAR-γ
… pregnancy, so we investigated the interaction of TGF-β and PPAR-γ on decidualization using cultured human endometrial stromal cell. METHODS: Human endometrial tissues were examined immunohistochemically for the expression of TGF-β receptors and transducer proteins in the TGF-β signaling. And we …
-
Andstæð hlutverk TGF-ß fjölskyldunnar í fylgjumyndun og meðgöngueitrun
… þá leiði það til meðgöngueitrunar. Meðlimir TGF-ß fjölskyldunnar spila stórt hlutverk í fylgjumyndun og virðast þeir hafa bæði hindrandi eða örvandi áhrif á íferð næriþekjufrumna. ANGPTL4 er prótein sem tjáð er í fylgju en hlutverk þess í fylgjumyndun er óþekkt. Í brjóstakrabbameinsfrumum …
-
TGF-beta 1 PATHWAY AND AGE-RELATED MACULAR DEGENERATION
… (Abeta) oligomers, and assess the effect of TGF-beta 1. Furthermore a topical formulation of transforming growth factor 1 (TGF-beta 1) was developed; and TGF-beta 1 ocular pharmacokinetics profile was assessed. Methods: Sprague-Dawley male rats were used. Human Abeta 1-42 oligomers were …
-
Molecular insights into signalling mechanisms within TGF-β superfamily
The TGF-β superfamily includes receptors, extracellular signalling molecules, their inhibitors and intracellular downstream signalling components. Members of the superfamily are present in all metazoans, expressed in all cells of the body and they are involved in embryonic development, adult tissue …
-
Knochenneubildung durch induktive Implantate der TGF-Beta-Familie : eine tierexperimentelle Studie zum Synergismus von BMP-2-Mutanten und TGF-Beta bei der heterotopen Osteoinduktion
… mit dem nicht osteoinduktiven Wachstumsfaktor rh-TGF-ß-1 zu steigern ist. Hierzu wurden zylinderförmige (Länge l=10mm, Durchmesser Ø=5mm), bovine EXKK-Träger (extrahiertes, xenogenes Knochen-Kollagen) mit den genannten BMPs, TGF-ß-1 und Kombinationen dieser Wachstumsfaktoren bestückt und für 28 …
-
The effect of EGFL7 on the TGF-β/BMP family
… í fylgjunni en sýnt hefur verið fram á að TGF-β fjölskyldan komi meðal annars að stjórnun æðamyndunar. Einnig hefur verið sýnt fram á að TSP-1 hindri æðamyndun í æðaþelsfrumum og að æðaþelspróteinið EGFL7 geti leitt til aukins frumuskriðs í fylgjumyndun. Takmörkuð þekking er á …
-
Effects of TGF-β Inhibitor on Chemoresistance in Ovarian Cancer Models
… High levels of Transforming Growth Factor-β (TGF-β) was linked to poor prognosis, chemoresistance and metastasis risk in HGSC. Mechanisms include roles of TGF-β promoting epithelial to mesenchymal transition (EMT) and immune evasion via suppression of Granzyme B (Gzmb) and Perforin (Prf1) …
-
Untersuchungen zu Bedeutung von TGF-β während der Entwicklung des Vorderhirns
Die transformierenden Wachstumsfaktoren β (TGF-βs) sind multifunktionale Zytokine, die zahlreiche zelluläre Prozesse in einer kontextabhängigen Weise regulieren können. TGF-βs und ihre Signaleffektoren sind im Vorderhirn exprimiert, über die Funktion von TGF-βs während der Entwicklung des …
-
Role of Type III TGF-β Receptor Shedding in Regulating Tumorigenesis
<p>The type III TGF-β receptor (TβRIII) is a TGF-β co-receptor that presents ligand to the type II TGF-β receptor to initiate signaling. TβRIII also undergoes ectodomain shedding to release a soluble form (sTβRIII) that can bind ligand, sequestering it away from cell surface receptors. We have …
-
A Study of TGF‐β Signaling in B Lymphocytes and Glioblastoma
<p>Transforming growth factor–β (TGF–β) signaling regulates a range of processes in a variety of cell types. Consequently, TGF–β plays a complex role in the progression of several types of cancers; it acts as a tumor suppressor in normal cells and early in tumor progression, yet it can promote …
-
TGF-β1-induced Chloride Channel Activity and Migration of Human Eosinophils
… and cytokines. Transforming growth factor (TGF)-β also induces asthmatic features in the lungs, especially airway remodeling. Eosinophils and TGF-β are closely linked to each other in the induction of airway remodeling. TGF-β activity also affects chloride channel activity, which can …
-
TRAIL and TGF-ßl-Induced Apoptosis of Human Airway Epithelial Cells
… Eosinophils, primary inflammatory cells, release TGF-ßl, a potent mediator of epithelial damage. Expression of TGF-ßl is higher in asthmatics. TGF-ßl can induce apoptosis of airway epithelial cells, however, the underlying mechanism of apoptosis is not well defined. A new member of the TNF …
-
TGF-beta Activated Kinase-1 (TAK1) Is a Critical Prostate Tumor Suppressor
TGF-beta activated kinase-1 (TAK1) encoded by the MAP3K7 gene is a serine/threonine protein kinase that functions in the regulation of cell proliferation, apoptosis, differentiation and/or inflammation. Genetic studies have shown that hemizygous deletion of the MAP3K7 gene is frequent (32%) in …
-
Isolierung, Charakterisierung und Funktionsanalyse von TGF-Beta-Signaltransduktionskomponenten des Fuchsbandwurms Echinococcus multilocularis
… zur Steuerung von Entwicklungsvorgängen ist das TGFβ/BMP-System, das aus strukturell verwandten Zytokinen der TGFβ (transforming growth factor β) bzw. BMP (bone morphogenetic protein)-Familie, oberflächenständigen Rezeptoren der TGFβ-Rezeptorfamilie (Typ I und Typ II) und intrazellulären …
Page 1 of 27