Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"TGF ß1"”.
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Effects of acetylsalicylic acid on odontogenesis of human dental pulp cells and TGF-ß1 liberation from dentin
… of HDPCs in vitro and the influence of ASA on TGF-ß1 liberation from dentin. HDPCs were cultured in a culture medium with different concentrations of ASA: 25, 50, 75, 100, 200 μg/mL and 0 μg/mL as a control. The mitochondria activity of HDPCs was assessed using an MTT assay. Crystal violet …
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Polyunsaturated fatty acids and immune cell functions
… positive relationship between membrane AA and TGF-ß1 indicating that it is the individual long chain (LC) PUFA, i.e. AA that regulate the levels of TGF-ß1. Investigation of the effects of n-6 and n-3 PUFAs on normal healthy PBMC production of TGF-ß1 in vitro showed that PBMC in the presence of …
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Transforming Growth Factor Beta1 und Platelet Derived Growth Factor im Serum und in bronchoalveolärer Lavage bei idioapthischen Lungenfibrosen
… Zytokine Transformig Growth Factor ß1 (TGF ß1) und Platelet Derived Growth Factor AB (PDGF-AB) im Serum und in der Bronchoalveolären Lavagenflüssigkeit (BALF) von 87 Patienten mit ILD mittels ELISAs. Dann suchten wir nach Korrelationen zu klinischen Parametern. Bei der Evaluation …
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Evaluierung synergistischer Effekte von rhBMP-2-Mutanten und TGF-Beta1 bei der induzierten Knochenbildung : eine In-vivo-Studie in Ratten
… veränderte Mutanten T3 und T4, jeweils mit rhTGF-ß1 kombiniert. Das Ziel der Studie bestand darin, nachzuweisen, ob TGF-ß1 die osteoinduktive Potenz dieser BMPs steigert. Als Proteinkonzentrationen wurden 0,5µg und 1µg des jeweiligen Proteins gewählt. Des Weiteren wurde untersucht, ob rhTGF-ß1 …
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Untersuchung der Interleukin-5-Rezeptor-Expression und der Aktivierung humaner eosinophiler Granulozyten
… des zerstörten Bronchialepithels benötigten TGF-ß1. <br> Im Rahmen dieser Arbeit konnte das Überleben und die Expression des Aktivierungsmarkers CD69 auf eosinophilen Granulozyten konzentrationsabhängig durch IL-3, IL-5 und GM-CSF gesteigert werden. Das antiinflammatorische Zytokin TGF-ß1 …
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Breast Cancer Cells Acquire a Stem-Like Phenotype by TGFß1/EGF Induced Epithelial-Mesenchymal Transition
… suggests that transforming growth factor (TGF)-ß and Epidermal Growth Factor (EGF) induces EMT and allows cancer cells to become more stem-like. We have shown that TGF-ß1 alone can partly increase expression of EMT-related transcription factors in BT-20 and MCF-7 cells. Furthermore, EGF …
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THE ABSENCE OF C3AR AND C5AR SIGNAL TRANSDUCTION PROMOTES T REGULATORY CELL DIFFERENTIATION AND REGULATES IMMUNOLOGIC TOLERANCE
… ceases, PKA activation increases, auto-inductive TGF-ß1 signaling initiates, and CD4+ T cells become Foxp3+ T regulatory cells (iTregs). Endogenous TGF-ß1 suppresses C3aR and C5aR signaling by preventing C3a and C5a production and upregulating C5L2, an alternate C5a receptor. Absent C3aR and C5aR …
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Proteínas de choque térmico y vesículas de membrana como posibles inmunomoduladores producidos durante la infección por rotavirus de células epiteliales intestinales
… los que se encuentra la citocina regulatoria TGF-ß1| pero también se liberan las proteínas de choque térmico (PCT) HSC70 y HSP70. Aunque tanto estas PCT como el TGF- ß1 se liberan principalmente de forma soluble, una parte de estas moléculas podrían liberarse de una forma asociada a vesículas …
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Plasma membrane-derived vesicles: composition and function
… in vitro. Further investigations with the TGF-p receptor antagonist, SB-431542, showed that this inhibition was due to TGF-ß1 present on PMVs, which initiates TGF-ß signalling. This thesis also identified a novel host cell entry strategy involving PMVs, employed by T. cruzi during …
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Identifizierung und Charakterisierung von Pkhd1, dem Maus-Ortholog des humanen ARPKD-Gens, sowie Erstellung und Analyse einer Pkhdl mutierten Maus
… phenotype and continuously immunoreact with TGF-ß1. Subsequently, mesenchymal cells within the hepatic portal tracts continue to synthesize collagen resulting in progressive portal fibrosis. The pathogenetic changes leading to congenital hepatic fibrosis in mice are absolutely equivalent to …
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Novel Preclinical Approaches to the Understanding and Treatment of Achilles Tendinopathy
… in a murine model. Our previously established TGF-ß1-induced murine model of Achilles tendinopathy was used to investigate the cellular mechanism by which ibuprofen (chemical) therapy might lead to a worsening of tendon pathology, potentially by interfering with the native inflammation phase of …
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Biologische Charakterisierung der Rezeptoren für Transforming Growth Faktor-ß
Transforming growth factor-ß (TGF-ß) reguliert eine Vielzahl zellulärer Funktionen, wie Proliferation, Differenzierung und Apoptose. Über membrangebundene Serin/Threonin-Kinase-Rezeptoren werden TGF-ß Signale durch Phosphorylierung an Smad-Proteine, die intrazellulären Signaltransduktoren, …
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Der humane Natrium-Jodid-Symporter (hNIS) : Entwicklung einer Methode zur Quantifizierung der hNIS-mRNA-Expression und Analyse der Rolle als Antigen bei autoimmunen Schilddrüsenerkrankungen
… investigated in the human system. An addition of TGF-ß1 or TNF-alpha on cultured human thyrocytes results in a significantly decreased hNIS mRNA expression. These data point out, that the human sodium-iodide-symporter is regulated similarly like the symporter of rats. As other thyroid proteins …
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Muscle Loading Treatments for Achilles Tendinopathy
… muscle complex using our preclinical TGF-ß1-induced murine model of Achilles tendinopathy. To accomplish our objective, we tested three muscle loading magnitudes (50%, 75%, and 100% body weight), over three treatment durations (1, 2, and 4 weeks) to determine their effects on tendon …