Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"TGFβ1"”.
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Modulation of TGFβ1-induced Fibroblast-to-Myofibroblast Transition in response to Prostaglandin E2 Production by Human Rhinovirus-Infected Airway Epithelial Cells
… airway walls. Transforming growth factor beta-1 (TGFβ1) is highly expressed in asthmatics and is known to upregulate fibroblast alpha-smooth muscle actin (α-SMA) expression, a characteristic marker of myofibroblasts. Given that human rhinovirus (HRV) infections are postulated to be involved in the …
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Treatment-resistant ophthalmoplegia in Myasthenia gravis: extraocular muscle pathology, the role of TGFβ1 and the derivation of induced pluripotency towards 'disease-in-a-dish' modeling
… focussed on transforming growth factor beta-1 (TGFβ1) as a critical cytokine involved in muscle repair. An auto-induction pathway in muscle allows TGFβ1 expression to influence the transdifferentiation of satellite cells into myofibroblasts or myoblasts. In orbital fibroblasts, TGFβ1 has also …
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Modulation of human adipose-derived stem cells and dermal fibroblasts in co-cultures by activation of the IL-6 trans-signalling pathway via the soluble IL-6Rα receptor
… In addition, secreted cytokine levels (TGFβ1, TGFβ3 and VEGF) and biomarker expression (TGF β1RII, SMAD2/3, SMAD 1/5/9 and SMA) were quantitated. Although both cell types secreted IL-6, ADSC basal levels were 100-fold that of DF. Both cell types expressed CD130 (gp130) signalling …
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hepatocyte growth factor inhibits glial scar formation and
… in primary astrocyte culture. Treatment of TGFβ1 led to astrocytic hypertrophy that was associated with dramatic upregulation of intermediate filament, GFAP (glial fibrillary acidic protein), which was evidently suppressed by HGF cotreatment in a dose-dependent manner. HGF also inhibited …
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Relationship between Processing Body Formation, Epithelial-to-Mesenchymal Transition, and Invasion in Lung Adenocarcinoma
… factors, like ZEB1, and enhanced response to the TGFβ1 cytokine. In oncogenic contexts, TGFβ1 enhances the formation of processing-bodies (P-bodies) where P-body proteins are required for invasion in multiple cancerous cell lines. P-bodies are a type of ribonucleoprotein (RNP) granule that assist …
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The expression and regulation of pregnancy-specific glycoproteins in the mouse
… the induction of cytokines such as IL-10 and TGFβ1 in monocytes, and more recently, have been shown to inhibit the platelet-fibrinogen interaction. I provide new information concerning the evolution of the murine Psg genomic locus structure and organisation, through the discovery of a recent …
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The Glial Response to Focused Ultrasound-mediated Permeabilization of the Blood-brain Barrier: Evaluating the Potential Contribution of Microglia and Astrocytes to Pathology and Regeneration
… upregulated transforming growth factor beta 1 (Tgfβ1), and activated astrocytes were hypertrophic and expressed nestin. MORPHIOUS can therefore sensitively detect activated glia. Secondly, I used MORPHIOUS to characterize microglial and astrocytic activation from 1 to 30 days (D) post-FUS. …
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Post-translationally Modified Glucocorticoid Receptors and Protein Tyrosine Kinase 6 Modulate Triple Negative Breast Cancer Phenotypes
… encompasses Transforming Growth Factor β1 (TGFβ1) and Mitogen Activated Protein Kinase (MAPK) signaling gene sets associated with TNBC cell survival and migration/invasion. Accordingly, pS134-GR was essential for TNBC cell anchorage-independent growth in soft-agar, migration, invasion, and …
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Microglia regulate myelin growth and integrity in the central nervous system white matter
… be regulated by transforming growth factor β 1 (TGFβ1), a factor primarily produced by microglia, which regulates expression ii of its receptors e.g., TGFβR1. Accordingly, TGFβ1 levels in FIREΔ/Δ white matter were reduced, and oligodendroglial TGFβR1 expression was downregulated. Additionally, …
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Characterising epithelial to mesenchymal transition and pro-fibrotic processes in chronic obstructive pulmonary disease
… 25ml RPMI media =100%) over time. IL-6, IL-8 and TGFβ1 responses were measured by ELISA and statistical comparisons made.ResultsEMT marker S100A4 was significantly (P<0.05) raised in COPD patients. The other EMT biomarkers (desmin, αSM actin and collagen) also showed numerical increases over NS …
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Engineered microenvironments for studying liver progenitor differentiation
… a cooperative influence of Jagged-1 and TGFβ1 on cholangiocytic differentiation. We established ECM-specific effects using cellular microarrays consisting of 32 distinct combinations of collagen I, collagen III, collagen IV, fibronectin, and laminin. In addition, we demonstrated that …
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Modulating Bone morphogenetic protein (BMP) and Transforming growth factor-beta (TGF-β) signalling with green tea catechins in mammalian cells
… tea catechin compounds inhibit TGFβR-II and TGFβ1-induced SMAD-dependent by reducing reporter activity, reduce the phosphorylation of SMAD3 proteins, and decrease the expression of pai-1 transcript. These green tea catechin compounds also decreased the BMP4-induced phosphorylation of p38 …
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Use of fourier transform- infrared spectroscopic imaging as a tool for understanding early molecular events driving breast cancer progression
… were stimulated using the growth factor TGFβ1, co-culture with MCF-7 tumorigenic breast epithelial cells, and co-culture with MCF10A normal breast epithelial cells in trans-well co-culture and also three-dimensional cell culture. α-SMA expression was determined using immunofluorescence …
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Extracellular-matrix mediated regulation of human uterine leiomyoma smooth muscle cells and potential targeting by the anti-fibrotic drug halofuginone
… reduce transcript levels of COL11A1, COL3A1, TGFβ1, TGFβ3, DMT and LOX3 in a time-depenedent manner; (3) expression of collagen I and III proteins were reduced by HF in a time-dependent manner; (4) PDGF-stimulated activation of the MAPK and SRC signaling pathways is not significantly inhibited …
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Investigation of the effects of Mechanical Strain in Human Tenocytes
… Cultures were treated with or without 1ng/ml TGFβ1 or inhibitors of TGFβRI, metalloproteinases, RGD, Mannose-6-phosphate, integrin β1 and a thrombospondin as appropriate. qRT-PCR and a cell based luciferase assay were used to assess RNA and TGFβ activity respectively. The prolonged application …
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Engineered 3D microenvironments to understand and direct liver progenitor and cancer cell fate
… them to be very susceptible to the growth factor TGFβ1 and the introduction of polymer microparticles to push differentiation towards a desired fate. The other system utilized a tunable microarray system to create geometrically controlled hepatocellular carcinoma spheroids and 3D cancer co-culture …
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Functional, Structural and Molecular Alterations in the Heart and Kidney During Diabetes Mellitus
… and underlying transforming growth factor β1 (TGFβ1) activity, gene expression profile of the ECM and calcium mediators using histological, immunohistochemical and quantitative gene expression analyses compared to age-matched Wistar control rats. Results: The results show that T1DM over 4 …
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Immune Mechanisms of Mesenchymal Stem Cell Therapy for Acute Graft versus Host Disease
… factors and direct cell contact. MSC derived TGFβ1 and prostaglandin E2 were involved in this induction. Murine MSC suppressed dendritic cell (DC) maturation, antigen presentation and cytokine production, inducing DC with tolerogenic attributes in vitro. MSC modulation of DC function was also …
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The fumonisin B₁-fed rat as a model for liver injury, oval ('progenitor') cell proliferation, and carcinogenesis
… an environment that selects for the growth of TGFβ1-resistant transformed liver cells. In rats given FB₁ in the presence of dietary iron overload, FB₁ augmented iron-induced lipid peroxidation in the liver. However, dietary iron loading appeared to protect against the cancer-promoting …
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