Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"TGFβ signaling"”.
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A dive into TGFβ signaling components during generation and degeneration of cartilage
Contains fulltext : 176468.pdf (Publisher’s version ) (Open Access)
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Bone-Specific Metabolism and Mechanism of Action of Curcuminoids in Blocking Osteolysis in Breast Cancer and Other Resorptive Bone Diseases
… osteoclasts release growth factors (e.g., TGFβ) stored in the bone, which can cause bone-metastatic tumor cells to secrete pro-osteolytic factors (e.g., PTHrP), resulting in more osteoclast-mediated bone resorption. Curcuminoids, dietary polyphenols derived from the turmeric rhizome, …
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Delineating the Mechanisms Through Which ZNF165 Supports Growth and Survival of Triple-Negative Breast Cancer
… and sustained transforming growth factor beta (TGFβ) signaling. However, the mechanisms through which ZNF165 functions in this context to regulate both TGFβ signaling and survival were poorly understood. To investigate its mechanism of action, I first sought to determine how ZNF165 interfaces …
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Molecular Basis of Sex Differences in Cardiac Hypertrophy and Heart Failure
… in part mediated by differential expression of TGFβ family members. To test this hypothesis, we utilized an angiotensin II pump infusion rodent model of cardiac hypertrophy in both male and female mice, followed by gene expression analysis and gene expression analysis of non-failing and failing …
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Analyzing The Role of Αvβ8 Integrin In Glioma-Induced Angiogenesis
… cell homeostatic control governed by canonical TGFβ signaling initiated by αvβ8 integrin’s role in the latent cytokine’s activation. Diminished TGFβ signaling in tumor-associated endothelial cells promoted increased angiogenesis and decreased overall survival as a result of αvβ8 integrin’s loss …
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A Reductionist Approach to Modeling Human Corticogenesis
… fate in an embryo requires elimination of TGFβ signaling. Using transgenic hPSCs, we show that inducible expression of a cell‐intrinsic inhibitor of canonical TGFβ signaling – SMAD7 – is sufficient to directly convert hPSCs to forebrain fate as seen by gene expression and immunocytochemical …
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Investigating the impact of endothelial BMPR2 loss on the proliferative response to bone morphogenetic protein 9 in pulmonary arterial hypertension
… activity or interactions with canonical TGFβ signaling, but was associated with the prolonged induction of the canonical BMP targets, the inhibitor of DNA-binding/differentiation genes, ID1 and ID2. In vivo, BMP9 administration reduced neonatal retinal and pulmonary vascular density in …
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Mechanisms for Maintaining Cell Identity in C.elegans Olfactory Neurons
… nsy-7 expression was restricted to AWCON by the signaling pathway that controls the initial fate decision. I collaborated with the Bulyk lab to discover a specific seven-nucleotide DNA sequence bound by the NSY-7 protein. This sequence was present in the srsx-3 promoter and required for …
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Dissecting combinatorial microenvironmental regulation of cell fate and function using a multi-modal arraying platform
… force microscopy (TFM); and the deconvolution of signaling via cell–cell (ligand–receptor) interactions by combining cell-extrinsic ligand presentation with cell-intrinsic ligand knockdown. I delineate the use of this platform towards investigations of microenvironmental regulation in the context …
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Defining mechanisms directing YAP/TAZ-mediated tumorigenesis
Dysregulated Hippo pathway signaling promotes the onset of aggressive cancers through the induced nuclear activity of yes-associated protein (YAP) and transcriptional co-activator with PDZ binding motif (TAZ) (YAP/TAZ). Uncontrolled nuclear YAP/TAZ activity evokes tumor-initiating properties in a …
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Investigation of Genetic Alterations In Emt Suppressor, Dear1, Through Pan-Cancer Analysis and Ultra-Deep Targeted Sequencing In Ductal Carcinoma In Situ
… regulator of polarity, tissue architecture, and TGFβ-driven epithelial-mesenchymal transition (EMT)<sup>1</sup><sup>,</sup><sup>2</sup>. Herein, I have shown by pan-cancer database analysis that chromosomal loss of <em>DEAR1</em> is a moderately frequent event in multiple epithelial cancers and …
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Oncogenic Kras and Telomere Biology In Crc Progression
… in part, by activating cancer cell-intrinsic TGFβ signaling and suppressing anti-tumoral immunity through the IRF2-CXCL3 axis, which recruits myeloid-derived suppressor cells. Regrettably, emerging therapies targeting KRAS* have demonstrated limited efficacy in clinical settings. This …
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Engineered microenvironments for studying liver progenitor differentiation
… as well as liver regeneration and disease. Both TGFβ and Notch signaling are known to play important roles in the liver progenitor specification process and subsequent tissue morphogenesis. However, the complexity of these signaling pathways and their currently undefined interactions with other …