Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"TGFβ‐BMP"”.
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The regulation of TGFβ/BMP signalling by deubiquitylating enzymes
… including the bone morphogenetic protein (BMP), plays critical roles during embryogenesis and in adult tissue homeostasis. Hence, malfunctions in TGFß/BMP signalling result in several diseases. Signalling is initiated by ligand binding to cell surface receptor kinases, which phosphorylate …
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SIGNALLING TISSUE RENEWAL AND CRYPT SURVIVAL IN THE HUMAN COLONIC EPITHELIUM AND BARRETT’S OESOPHAGUS
… cross-talk between the Wnt, Notch, EGF and TGFβ/BMP pathways. The molecular mechanisms that regulate the processes of tissue renewal in the human are of great interest because they are disrupted in colorectal cancer and inflammatory diseases. Barrett’s oesophagus is an intestinal metaplasia …
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Regulatory dynamics of transcription factors TBX18 and WT1 in mouse prostate development
… The data revealed a role for Wt1 upstream of the TGFβ/BMP pathway during prostate development, a signaling pathway known to inhibit over-proliferation of epithelial cells. Whereas WT1 has been known for some time to be dysregulated in human prostate cancer, its function in the normal prostate has …
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KLF4 IS A KEY DETERMINANT IN THE DEVELOPMENT AND PROGRESSION OF CEREBRAL CAVERNOUS MALFORMATIONS
… production of bone morphogenetic protein 6 (BMP6) in ECs that, in turn, activates the transforming growth factor-β (TGF-β) and bone morphogenetic protein (BMP) signalling pathway. KLF4 transcriptional activity and KLF4-dependent TGF-β/BMP pathway activation are responsible for the EndMT …