Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 109 for “"TGFβ"”.
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Decoding the structure WWP2 in the TGFβ signalling pathway
… proteins that propagate or inhibit the TGFβ pathway, and in so doing, allows WWP2 to regulate its Smad targets. WWP2 has three isoforms that are known to participate in regulation of TGFβ signalling, but, even amongst isoforms of the same E3, they exhibit different specificities for …
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Identification of novel protein kinase regulators of TGFβ signalling
… by members of the transforming growth factor-β (TGFβ) family of cytokines perform critical functions during embryonic development and adult tissue homeostasis. Accordingly, TGFβ family members are involved in the regulation of a diverse array of cellular processes including epithelial-mesenchymal …
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The regulation of TGFβ/BMP signalling by deubiquitylating enzymes
The transforming growth factor-ß (TGFß) pathway, including the bone morphogenetic protein (BMP), plays critical roles during embryogenesis and in adult tissue homeostasis. Hence, malfunctions in TGFß/BMP signalling result in several diseases. Signalling is initiated by ligand binding to cell …
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The Effects of Atypical Protein Kinase C on TGFβ Signalling
The transforming growth factor beta (TGFβ) signalling pathway is an essential regulator of many cellular processes including epithelial growth control, epithelial to mesenchymal transition (EMT), apoptosis, and the establishment of developmental fate. Alterations in TGFβ signalling patterns are …
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Post-Translational Regulation of Zeb1 Contributes to Tgfβ-Mediated Emt
<p>Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death in the United States due in part to the affinity of tumors to metastasize. Understanding the process which contributes to metastasis provides promise for the discovery of novel therapeutic targets. …
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Identificación y caracterización de elementos regulatorios distales controlados por TGFβ
… detallada, cómo los enhancers dependientes de TGFβ controlan la transcripción génica en células epiteliales. El tratamiento con TGFβ desencadena un incremento rápido y generalizado de la accesibilidad de la cromatina en el 80% de los enhancers, independientemente de si van a ser activados, …
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Identification and Characterization of the TGFβ/Hippo Crosstalk through Mathematical Modeling
Transforming Growth Factor-beta (TGFβ) superfamily members control a myriad of cellular activities and are key regulators of most developmental and homeostatic processes. The Hippo pathway is a major regulator of tissue growth and organ size. Hippo and TGFβ pathways are intimately interconnected. …
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TGFβ signalling in microglia and the impact of microglia-specific Smad4 deletion
… the role of transforming growth factor-β (TGFβ) signalling in microglia and the regulation of Smad4-mediated microglial functions, and their subsequent impact on central nervous system (CNS) homeostasis, neurodevelopment, and neuroinflammation. The study comprehensively describes the TGFβ …
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Regulation of the Tumor Suppressor ARF by TGFβ in Human Cancer Cells
… been shown by the Skapek lab to be induced by TGFβ in mouse embryonic fibroblast and HeLa cells. TGFβ itself has been well characterized for its role as a "dual-edged sword," acting as a tumor suppressor or oncogene depending on the context. Though preliminary work has looked at the basic …
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A dive into TGFβ signaling components during generation and degeneration of cartilage
Contains fulltext : 176468.pdf (Publisher’s version ) (Open Access)
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Src Kinase Regulates TGFβ And Hyaluronan Induced Epicardial Cell Invasion, Differentiation And Migration
… The Transforming Growth Factor β (TGFβ) family of receptors have been well described in regulating cardiovascular development. The Type III TGFβ receptor (TGFβR3) has been shown to be required for development of the coronary vessels. Mouse embryos lacking TGFβR3 exhibit inhibited …
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SGK196 controls stem cell fates by promoting the degradation of TGFβ family receptors
… as a novel regulator of cell fate and the TGFβ family signaling pathway. SGK196 depletion in human embryonic stem cells (hESCs) inhibits neural induction and enhances mesoderm induction, while SGK196 overexpression represses mesoderm and endoderm induction. SGK196 negatively regulates TGFβ …
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Modulation of TGFβ-Induced PAI -1 Expression by Changes in Actin Polymerization in Human Mesangial Cells
… role in ECM accumulation and tissue scarring. TGFβ increases ECM deposition by increasing plasminogen actuator inhibitor type-1 (PAI-1; expression. PAI-1 inhibits ECM degradation by tissue- (tPA) and urokinase-type (uPA) plasminogen activators. Additionally, the Rho family of GTPases is …
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CROSSTALK BETWEEN LYSOPHOSPATIDIC ACID (LPA) AND TRANSFORMING GROWTH FACTOR BETA (TGFβ) IN BREAST AND OVARIAN CANCER CELLS
… acid (LPA) and transforming growth factor beta (TGFβ) are platelet-derived intercellular mediators of cell proliferation and motility. LPA is a general growth, survival and motility-stimulating factor in mammalian cells. TGFβ prevents proliferation of normal epithelial cells. However, the …
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The role of NEDD9 in TGFβ mediated tumour initiating cell dynamics in the Claudin-low breast cancer subtype
… to treatment. Transforming growth factor β (TGFβ) a member of the TGF superfamily of cytokines differentially regulates breast tumour-initiating cells (BTICs). In the claudin-low breast cancer subtype, TGFβ increases the tumour initiating capacity through the ability of the scaffolding …
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Investigation of the effects of Mechanical Strain in Human Tenocytes
… An increase in the anti-inflammatory cytokine TGFβ has also been documented. This project aims to investigate the effect of cyclic tensile strain loading and TGFβ stimulation on protease and ECM protein expression by human tenocytes and begin to characterise the pathway of mechanotransduction. …
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The Transformation of Human Retinal Pigment Epithelial Cells
… the etiology of this disease is unknown, TGFβ has been implicated as a key factor contributing to PVR.</p> <p>The risk factors of PVR include a tear on the neural retina, breakdown of blood-retinal barrier, and inflammation. Retinal pigment epithelial (RPE) cells, a single layer of …
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Regulation of Human Osteosarcoma Cell Differentiation by Transforming Growth Factor B1 (TGFB and 1a,25- Dihydroxyvitamin D3 : the Mechanism of TGFB1 Potentiation of 1,25D3-induced Alkaline Phosphatase Activity in Human MG63 Osteosarcoma Cell
<p>Transforming growth factor β<sub>1 </sub>(TGFβ<sub>1</sub>) is a pluripotent cytokine that works in conjunction with other cytokines to modulate their effects on cell function. Our previous work demonstrated that the combination of TGFβ<sub>1</sub> and 1α,25-dihydroxyvitamin D<sub>3</sub> had a …
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