Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"TGFß"”.
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Transgenic use of SMAD7 to suppress TGFß signaling during mouse development
Neural crest cells (NCC) are a multipotent population of cells that form at the dorsal region of neural tube, migrate and contribute to a vast array of embryonic structures, including the majority of the head, the septum of the cardiac outflow tract (OFT), smooth muscle subpopulations, sympathetic …
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The regulation of TGFβ/BMP signalling by deubiquitylating enzymes
The transforming growth factor-ß (TGFß) pathway, including the bone morphogenetic protein (BMP), plays critical roles during embryogenesis and in adult tissue homeostasis. Hence, malfunctions in TGFß/BMP signalling result in several diseases. Signalling is initiated by ligand binding to cell …
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Der Einfluß von Steroiden und Medikamenten zur Behandlung der Multiplen Sklerose auf die LPS-induzierte iNOS/NO-Synthese in primärer Mikroglia neugeborener Ratten
… zeigte der Transforming Growth Factor-beta (TGFß) eine inhibierende Wirkung. Die Phosphodiesterasehemmer Rolipram und Pentoxifyllin, der Matrix-Metalloproteinasen-Inhibitor BB 3103 und das Zytokin Interleukin-10 zeigten in den Untersuchungen keinen Effekt. <br>Diese Untersuchungen zeigen, …
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The roles of hepatocyte growth factor family members in androgen-regulation of human hair growth. A comparison of the expression of hepatocyte growth factor family members, HGF and MSP, and their receptors, c-Met and RON, in isolated hair follicles from normal and androgenetic alopecia (balding) scalp.
… while putative inhibitory factors, e.g. TGFß-1, were increased. HGF and MSP and their receptors, c-Met and RON, were significantly reduced. These results increase our understanding of androgen action in human hair follicles; this could lead to better treatments for hair disorders.
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Crimpy Sorts a BMP into the Regulated Secretory Pathway for Activity-Dependent Release in Drosophila Motorneurons
… NMJ. Growth factors of the neurotrophin and TGFß superfamilies are secreted from vertebrate neurons in response to synaptic activity in addition to constitutive secretion. Sorting receptors for the neurotrophin BDNF have been identified that interact with precursor BDNF and direct its …
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Short-Range Inter-Blastomere Signaling Specifies Ectodermal Fate and is Required for Skeletal Patterning in the Sea Urchin
… from the endoderm to establish the BE fate, and TGFß signaling from the oral and aboral ectoderm which subdivides the BE into four territories. These findings demonstrate that the short-range signaling cascade that subdivides the embryo into first mesoderm and then endoderm also specifies …
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Alterazioni immunologiche su cellule mesenchimali stromali e linee cellulari di Leucemia Mieloide Cronica (LMC)
… dei livelli di espressione di αSMA, FAP1 e TGFß. La co-coltura tra le HS-5 e le LAMA-84 determina un aumento dei livelli di espressione di TLR4; mentre il trattamento con IGFBP-6, SHH e Dasatinib ne modula la sua espressione. CONCLUSIONE I pathway IGFBP-6 e SHH possono essere considerati …
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Model for tooth development in vitro
… hours of the culture model. Among them are the TGFß- and Activin, the FGF, the Wnt, and the Notch pathway. The bivalent results from transcriptional analysis, regarding the activation status of the MAPK pathway, were unraveled by a MAPK reporter assay, which evidenced an immediate-early MAPK …
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Estudio de la influencia de los fibroblastos del estroma tumoral en el comportamiento de los carcinomas mamarios
… unión al calcio S100A4, factores de crecimiento (TGFß, HGF, FGF2, FGF7, PDGFA, PDGFB, VEGFA y IGF2), citoquinas inflamatorias (IL6 y IL8), quimiocinas (CCL2 y CXCL12), proteasas (uPA, MMP2, MMP9 y MMP11), el factor de transcripción NF¿B y TIMP1. También se analizó mediante cocultivos de los CAFs …
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Klonierung und Charakterisierung von Rezeptorkinasen der EGF- und TGF-Beta-Familie des kleinen Fuchsbandwurmes Echinococcus multilocularis
Rezeptorkinasen spielen eine wichtige Rolle in der Kommunikation von Zellen mit ihrer Umgebung und sind möglicherweise an hormonellen Kommunikations- Mechanismen zwischen parasitären Helminthen und ihren Säugetier- Wirten beteiligt. In dieser Arbeit wurden erstmals eine Rezeptor- Tyrosinkinase der …
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Isolierung, Charakterisierung und Funktionsanalyse von TGF-Beta-Signaltransduktionskomponenten des Fuchsbandwurms Echinococcus multilocularis
Die molekularen Mechanismen der Wirt-Parasit-Interaktion bei der durch den Zestoden Echinococcus multilocularis ausgelösten Erkrankung der alveolären Echinokokkose sind bislang ungeklärt. Zudem liegen keine Daten über Entwicklungs- und Differenzierungsmechanismen dieses Parasiten vor, die für die …