Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"TFIIH"”.
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The Role of Phosphorylation in Modulating PC4 Function as a General Cofactor
… of multisubunit protein complexes such as human TFIIH and RNA polymerase II has been a tedious task by conventional chromatography. To overcome the difficulty in isolating human TFIIH and RNA polymerase II, which play an essential role in eukaryotic transcription, we have developed an effective …
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General Transcription Factors Play Dual Roles In Initiation And Termination
… The general transcription factors TFIIB and TFIIH have been found to interact genetically with Ssu72, a component of CPF 3' end processing complex. Accordingly, we found that TFIIB and TFIIH localize to the distal ends of genes in a transcription dependent manner. TFIIB localization at the …
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Mechanistic Understanding of the Role of TRF1 in Telomere Replication
… the general transcription factor IIH (TFIIH) complex is also important for facilitating telomere replication. Deleting components of the TFIIH complex causes extensive fragile telomere formation and telomere replication stress. Lastly, I have determined the nature of sister telomere …
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Genome-wide analysis of transcription factors and chromatin in S. cerevisiae
… Srb/Mediator complex, and the Kin28 subunit of TFIIH demonstrated that these factors are required for the transcription of essentially all protein-coding genes in yeast. However, other components of the Srb/Mediator complex (Srb5, Med6, SrblO, Swi2), the general transcription factor TFIID …
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XPD Helicase: Shifting the Inchworm Into Reverse
… How human XPD functions as part of the TFIIH complex in nucleotide excision repair was also explored by looking at unwinding in the presence of the ssDNA binding protein, RPA, a known component in NER. This work also is the first to provide evidence for the orientation of a SF2B helicase …
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Identification of novel components of the zinc homeostasis mechanism in Arabidopsis thaliana
… of the basal transcription factor complex (TFIIH) and three histone families) of this complex were indentified. However further experiments will be required to prove the effect of the point mutation on the structure of the protein and its interaction with cullin 4 ubiquitin E3 ligase as well …
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Control of Replication Fork Stability by Chromatin and S-phase Checkpoint
… alterado por la retención excesiva del complejo TFIIH tras la acción de las endonucleasas Rad1 y Rad2. Como consecuencia, las lesiones inducidas por ultravioleta daban lugar a huecos de cadena sencilla en el ADN que se convierten en roturas de doble cadena tras la replicación. En segundo lugar, …
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Single-molecule optical trapping studies of the regulation mechanisms of XPD helicase
… repair (NER), and functions as part of the large TFIIH complex in eukaryotes. However, its mechanism in archaeal organisms, which lack many eukaryotic repair proteins, remains unclear. Using optical tweezers, I investigated how multimeric XPD from Ferroplasma acidarmanus achieves synergistic …