Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"TET family"”.
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Maintaining Proper Levels of DNA Methylation Marks Through the TET Family is Critical for Normal Embryo Development in Pigs
… embryo development. Ten-eleven translocation (TET) methylcytosine dioxygenases are implicated in DNA demethylation by catalyzing the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). The three members of TET protein family, TET1, TET2, and TET3, are highly expressed in …
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ELUCIDATION OF MECHANISMS GENERATING 5-HYDROXYMETHYLCYTOSINE (5hmC) IN MAMMALIAN MITOCHONDRIA
… gene expression, and development. Recently, the Tet family of methylcytosine dioxygenases(Tet1, Tet2 and Tet3) was found to catalyze the oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), an intermediate in the pathway of DNA demethylation. Tet enzymes catalyze this …
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Nucleobase, Nucleoside, And Neighboring Nucleotides: Intrinsic Preferences For Tet Enzyme-Mediated Oxidation Of 5-Methylcytosine
The Ten-eleven-translocation (TET) family of enzymes can oxidize the fifth base of DNA, 5-methylcytosine (mC) sequentially, to 5-hydroxymethylcytosine (hmC), 5-formylcytosine (fC), and 5-carboxycytosine (caC). The biochemical preference of TET enzymes for these substrates, in the canonical cytosine …
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Exploring functional significance of asymmetric DNA methylation in early mammalian development
… Moreover, mCH cannot be hydroxylated by the Tet family of enzymes, and repels proteins involved in the initiation of base-excision repair (AID and RPA), thus potentially escaping active demethylation in the zygote. In summary, my results show that mCH is a valid methylation mark, with a …
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Characterization of 5-methylcytosine dioxygenase Tet2 and rescue of mutant Tet2 activity by using turbo co-substrate
… by ten-eleven translocation dioxygenases (TET1-3), followed by thymine-DNA glycosylase-dependent base excision repair. Inactivation of the TET2 gene due to genetic mutations or other epigenetic mechanisms is associated with poor prognosis in patients with diverse cancers, especially …
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Regulation of De Novo and Maintenance Dna Methylation By Dnmt3A and Dnmt3B
… derivatives by the ten-eleven translocation (TET) family of dioxygenases represents a breakthrough in the field. Since the discovery, great progress has been made in elucidating the DNA demethylation pathways. In addition to being an intermediate in DNA demethylation, 5hmC may also serve as an …
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Metabolomics and chemical library screening for antibacterial drug discovery
… the activity of Ten-Eleven Translocation 2 (TET2) enzyme. Methylation of one of the DNA bases, cytosine at the C-5 position (5-methylcytosine, 5mC) plays a crucial role in epigenetic transcriptional regulation. TET-family dioxygenases (TET1, TET2 and TET3) initiate active demethylation of …