Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"TERT promoter"”.
-
Predicting protein-DNA interactions using statistical modeling and biophysical representations of high-throughput sequencing data
… that can immortalize cancer cells by activating TERT when specific mutations are present in its promoter. We perform and analyze RNA-seq and chromatin immune-precipitation sequencing of GABPA and histone modifications in cancer cell lines with TERT promoter mutation and demonstrate that GABP …
-
Circulating tumour DNA: A non-invasive biomarker for melanoma
… Notably, telomerase reverse transcriptase (TERT) promoter mutations are present in 50-70% of melanomas and confer a significantly poorer prognosis if found concurrently with BRAF or NRAS mutations relative to the occurrence of each mutation alone. Thus, the ability to monitor patients at all …
-
FROM NUCLEUS TO MITOCHONDRIA: INSIGHTS INTO THE ROLE OF TERT IN THE PROGRESSION OF PAPILLARY THYROID CARCINOMA
TERT is the protein component of the telomerase holoenzyme and has been reported overexpressed in many cancer types. The most studied role for TERT in cancer is the regeneration of telomeres allowing the avoidance of senescence and, in turn, the continued proliferation of cancerous cells. Recent …
-
Trees and Forests: Data Science and Machine Learning Approaches to Characterise Clonal Haematopoiesis
… drivers of sporadic CH, namely mutations in the TERT promoter, outlining how they mirror the age distribution of splicing factor mutations and portend a risk of pulmonary fibrosis. Taken together, this body of translational work develops novel strategies for scalable CH detection, establishes …
-
Characterizing and targeting the genomic consequences of ATRX deficiency in glioma
… These mutations are mutually exclusive with TERT promoter mutations, promoting the alternative lengthening of telomeres (ALT) pathway as a telomere maintenance mechanism in ATRX-deficient glioma. Recently, a class of agents known as G4 stabilizers demonstrated strong therapeutic promise, …
-
Dissecting the genomic and epigenomic alterations underlying glioblastoma
… somatic small mutations (SSMs) apart from TERT promoter mutations. We identified loci under putative selection for SV recurrence, including those harbouring focal amplications and deletions, associated with complex SVs such as extrachromosomal DNA (ecDNA) and chromothripsis. We discovered …