Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"TEN1"”.
-
Biochemical analysis of proteins in the telomere maintenance pathway
… In yeast, Cdc13 recruits either Stn1-Ten1 to form a protective cap or the telomerase holoenzyme to extend the DNA. I have established an in vitro yeast telomere system in which Stn1-Ten1-unextendable or telomerase-extendable states can be observed. Notably, the yeast Hsp90 chaperone …
-
Clarifying the Role of the CST Complex in DNA Replication and Repair
… the shelterin complex and CST (CTC1 – STN1 – TEN1) complex. CST is an RPA-like ssDNA binding protein that is vital for telomere length maintenance via inhibition of telomerase and stimulation of DNA polymerase α -primase during C-strand fill-in synthesis. CST is also known to possess …
-
Mechanisms That Ensure the Proper Terminal Structure of Mammalian Telomeres
… the telomeric function of the Ctc1/Stn1/Ten1 (CST) complex. Though the role of CST is not well understood, Ctc1 and Stn1 were originally identified as accessory factors of DNA polymerase α/primase and may contribute to fill-in synthesis of the telomeric C-rich strand. Finally, to identify …
-
Biochemical and structural studies of human telomerase regulation
… telomerase is terminated by a CST (CTC1-STN1-TEN1) complex (Feng et al., 2018). In my thesis, I describe the biochemical and structural work aimed at understanding the molecular basis of human telomerase and its interaction with regulatory factors. In Chapter 2, I reconstruct telomerase …
-
On the Second Telomere Maintenance Machine: Structure, Recruitment, and Regulation of the CST–Polα/primase C-strand Fill-in Complex
… Polymerase α (Polα)/primase bound to Ctc1/Stn1/Ten1 (CST). Decades of research have focused on telomerase, which extends the G-rich telomeric strand to counteract telomere shortening in germline and stem cells. More recently, CST–Polα/primase,which synthesizes the complementary C-rich strand, …