Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"TEDOR"”.
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State-of-the-art REDOR and TEDOR methods for elucidation of protein structure and interactions
… (REDOR) and transferred echo double resonance (TEDOR) that recouples the dipolar couplings between two selective heteronuclear spins present in the biomolecule. The dipolar coupling is directly proportional to the gyromagnetic ratio (g) of the spins and indirectly proportional to the cube of the …
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Structural studies of amyloid fibrils using solid-state NMR
… and intersheet distances including REDOR, TEDOR, R2TRW, and DARR. The intermolecular distances were combined with the previously solved monomer structure to generate a high resolution (RMSD of 1.0 Å) of the TTR protofiliment. A disease associated mutant (L 11 M) of these fibrils was also …
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Solid state nuclear magnetic resonance methodology and applications to structure determination of peptides, proteins and amyloid fibrils
… transferred-echo double-resonance (3D TEDOR) methods for carbon-nitrogen distance measurements in (U-'3C,S5N)-labeled peptides and proteins are described. FSR employs frequency selective Gaussian pulses in combination with broadband REDOR recoupling to measure dipolar couplings based on …
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Solid-State Magic-Angle Spinning NMR Methods for Tensor Measurements and Protein Structure Refinement Using Chemical Shift Tensors
… and distance information using the REDOR and TEDOR heteronuclear dipolar recoupling pulse sequences. Data from these experiments reveals important structural information, reporting directly upon secondary structure, hydrogen bonding, and electrostatics. This work culminates in the first …
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Ligand-Protein Interactions in Cytochromes
… best method is selectively labeled samples with TEDOR experiments. In addition, cytochrome c553 was used as a model to evaluate the role of the thioether linkages in c-type cytochromes. Since c-type and b-type cytochromes are the most abundant and c-type cytochromes are biosynthesized from …
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Structure determination of proteins and protein aggregates by magic-angle spinning solid-state NMR
Solid state NMR (SSNMR) is a structure determination technique uniquely suited to study protein aggregates and fibrils. Unlike solution NMR or X-ray crystallography, SSNMR can obtain atomic resolution structural information on samples of protein fibrils which are insoluble and do not produce X-ray …