Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"TECS"”.
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Wnt Secretion Proteins Modulate RANKL-Induced Expression of Aire in Thymic Epithelial Cells
… establishing central tolerance. In the thymus, TECs differentially express Wnt proteins, which activate canonical and non-canonical Wnt signaling pathways. Wnt signaling is thought to regulate cell survival, proliferation, and development although the direct molecular mechanisms in TECs have yet …
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Characterization of Non-Coding RNAs in Regulating Thymic Epithelial Cell Responses to Pathophysiological Stress
… A deficiency of miR-205 specifically in TECs renders these cells more susceptible to stress mediated thymic involution. This is revealed by a significant loss in developing thymocytes, altered migration, delayed recovery of single positive thymocyte selection, and proliferative defects in …
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Bone Marrow Derived Progenitor Cells and Their Contributions to the Thymic Stroma
… in T-cell function.Thymic epithelial cells (TECs) are the most critical component of the thymic microenvironment and undergo rapid turn-over, so understanding the cellular mechanisms responsible for the maintenance of TEC number and organization will be critical in counteracting age …
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Realizing a design for a cloud chamber cooled by thermoelectric modules
… explores the use of thermoelectric coolers (TECs) instead of dry ice to create the temperature difference needed to visualize radiation particles. The TECs, which are cooled by a Liqmax II 120S liquid CPU cooler, interface with a copper plate on which isopropyl alcohol forms a super-saturated …
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Enforced Expression of Tbx1 In Fetal Thymic Epithelial Cells Antagonizes Thymus Organogenesis
… level of <em>Foxn1 </em>expression in fetal TECs was significantly reduced. TECs in <em>R26<sup>iTbx1/+</sup></em> thymi assumed an almost universal expression of Plet-1, a marker associated with a TEC stem/progenitor cell fate. In addition, embryonic <em>R26<sup>iTbx1/+</sup></em> mice …
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Determination of Thymic Epithelial Cell Composition and Proliferation During The Perinatal to Adult Transition
… types, particularly thymic epithelial cells (TECs). The thymus develops rapidly during the perinatal time period (birth – 10 days in mice) before reaching a period of homeostasis (10 days – 6 weeks). The mechanisms that initially promote and subsequently limit expansion of the TEC compartment …
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Defining The Molecular Networks Necessary For Thymus Fate and Organogenesis
… of <em>Tbx1 </em>in thymic epithelial cells (TECs) suppresses FOXN1, inhibits TEC proliferation and arrests TEC differentiation, suggesting <em>Tbx1</em> must be tightly regulated in the 3<sup>rd</sup> pp endoderm for proper thymus organogenesis to occur. Members of the <em>miR-17-92 …
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An integrated TQM approach for the development of medium size organisations.
… organisations.In this thesis I have considered TECs as medium-size organisations. In order to develop a TQM approach for TECs I have considered a number of TQM authorities and compared their principles with the European Quality Award (EQA) model in order to develop a model suitable for TECs.In …
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Developing a simulation-based approach to collision risk of tidal energy converters and marine wildlife
… energy, making tidal energy converters (TECs) a desirable source of electrical generation. However, the drive for sustainable development and the legislative protection of species and habitats means that, in most countries, the environmental impacts of TECs must be quantified before …
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Response of suction caissons in soft clay under vertical and horizontal loading for tidal energy converter applications
… requires the use of tidal energy converters (TECs), a technology that is still primarily in the development and prototyping phases. As such, design standards for TECs have not yet been developed. In order to develop such standards and deploy an economical, efficient, and reliable final …
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Understanding heat transport at interfaces for thermal management of electronics
… measure the thermal expansion coefficients(TECs) of various 2D materials. Our measurements confirmed the correct physical range of 2D monolayer TECs and hence addressed the more than two orders of magnitude discrepancies in literature. Second, we investigated the thermal transport across …
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Training and enterprise councils, innovatory practice and special needs
… funded by Training and Enterprise Councils (TECs) in England in order to establish the extent to which training and employment opportunities are responsive to the needs of disabled people. It considers the current position of disabled people in society and work and the effects of reduced …
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Factors and mechanisms of archaeal transcription termination and DNA repair
… terminating transcription elongation complexes (TECs) in Archaea from the genetically tractable Thermococcus kodakarensis, and use both factors as models to explore the molecular mechanisms involved in collapse of the TEC. The Factor that terminates transcription in Archaea (FttA), a close …
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Investigating The Ecology and Evolution of Normal Breast Tissues and Breast Cancer With Single Cell Genomics
… macrophages (TAMs), and tumor endothelial cells (TECs), have shown to play a role in tumor progression. One knowledge gap is the role macroenvironmental changes confer on chemoresistance in TNBC patients. To order to investigate the transcriptional reprogramming of the TME, we performed single …
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Assessment of gentle remediation options for trace element-contaminated agricultural land under semi-controlled and field conditions
… towards arable TE-contaminated soils (TECS) could protect highly biodiverse or carbon stock land and, thereby, help reach global sustainability targets. The sustainable crop production on TECS requires effective and non-destructive measures to control relevant pollutant linkages. These …
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Preventing Thymus Involution In K5.Cyclin D1 Transgenic Mice Sustains The Naïve T Cell Compartment With Age
… D1 (K5.D1) transgene in thymic epithelial cells (TECs). Thymopoiesis occurs normally in K5.D1 transgenic thymi and sustains T cell output to prevent the age-associated decline of naïve T cells in the periphery. We find that K5.D1 recent thymic emigrants (RTEs) undergo typical phenotypic …
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Peak Current Mode Driver for Thermoelectric Cooler
Thermoelectric coolers (TECs) are solid state devices that use the Peltier effect to provide heating or cooling for an enclosed area when a voltage is applied. In order to both heat and cool, a bidirectional current must be supplied to the TEC. Therefore, a driver circuit is needed to supply the …
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SPECTROSCOPIC ASSESSMENT OF TISSUE ENGINEERED CARTILAGE: A PATHWAY FOR BENCH TO BEDSIDE EVALUATION OF CARTILAGE DEVELOPMENT AND REPAIR
… extracellular matrix components of cartilage and TECs for in vitro monitoring of TEC development by fiber optic NIR spectroscopy; 2. Assessment of the Vis-NIR spectral features of tissues present in the mini-pig stifle joint during the chondral repair process to facilitate interpretation of in …
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Generation and Characterization of Micron and Sub-micron Sized Particulate using Electrothermal Plasma Source SIRENS
The Surface Interaction Research Experiment at North Carolina State (SIRENS) is an electrothermal plasma facility which was recently used to generate particulate for the enhancement and modification of surfaces. The modification of fabrics by surface coating or particle implantation was a specific …
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Single-cell atlasing of the human tissues across the lifespan
… cells, including thymic epithelial cells (TECs), fibroblasts, vascular and myeloid cells. Simultaneously, I use the cortico-medullary axis to compare the spatial position of cell types in the fetal vs. paediatric thymus. I conclude by discussing the differences in cell type localisation …
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