Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"TDP1"”.
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Nonhomologous end-joining: TDP1-mediated processing, ATM-mediated signaling
… active site of tyrosyl-DNA phosphodiesterase (TDP1). To address how the H493R mutation elicits the specific pathologies of SCAN1 and to further elucidate the role of TDP1 in processing DNA end modifications, we generated a Tdp1 knockout mouse and characterized their behavior and specific repair …
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Structural and Inhibitor Binding Studies of Tyrosyl-DNA Phosphodiesterase 1
… on human tyrosyl-DNA phosphodiesterase 1 (TDP1), which is a DNA repair enzyme that is present in eukaryotes including humans. TDP1 is a monomeric protein from the phospholipase D (PLD) superfamily. TDP1 is involved in the repair of topoisomerase-mediated DNA damage during DNA replication …
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Functional Roles of Nucleases in DNA Metabolism and Genome Stability
… and a different pathway must repair the Top1-cc. Tdp1-dependent repair of Top1-cc requires prior proteolytic processing of the Top1-cc before it can be removed leaving a 3'-phosphate that can be removed by Tpp1, Apn1, or Apn2 forming a substrate suitable for repair by DNA polymerase δ, FEN1 and …