Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 45 for “"TDP-43"”.
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TDP-43 and its role in neurodegeneration
Ubiquitinated TDP-43 (TAR DNA Binding Protein) inclusions are a hallmark of ALS (amyotrophic lateral sclerosis) and FTLD-TDP-43 (frontotemporal lobar degeneration with ubiquitin inclusions). These diseases share a similar pathology of cytoplasmic ubiquitinated TDP-43 inclusions, which contain …
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Rekombinantinio TDP-43 baltymo sintezės ir gryninimo optimizavimas /
… synthesis and purification of recombinant SUMO-TDP-43 protein in E. coli cells. The targeting protein is important in the context of neurodegenerative diseases, as accumulations of amyloid TDP-43 aggregates cause cell damage. The preparations carried out in this work included the synthesis of …
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Relationship Between TDP-43 Toxicity and Aggregation in Saccharomyces Cerevisiae
… in the brain. TAR-DNA-binding protein (TDP-43) is the major component found in the pathological inclusions of two of these diseases, ALS and frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U). This thesis focuses upon the biophysical basis for TDP-43 …
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Dynamic changes of TDP-43 in testicular and epididymal sperm
TAR DNA-binding protein of 43 kDa (TDP-43) is a ubiquitously expressed and evolutionarily conserved protein. TDP-43 is a DNA/RNA binding protein with several functions such as gene transcription, mRNA splicing and stability, transposon silencing, and micro RNA biogenesis. TDP-43 is associated with …
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Exploring the Mitigation of TDP-43 Toxicity by Sis1 in Yeast
… has revealed that Tar DNA-binding Protein 43 cytoplasmic aggregates are involved in many cases of Amyotrophic Lateral Sclerosis. One possible mechanism for TDP-43 induced toxicity is that these aggregates are titrating away a molecular chaperone protein, Sis1, from the nucleus of the cell. …
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Investigating the molecular environments and interactions of pathological TDP-43 filaments
… transactive response DNA-binding protein 43 (TDP-43) pathology characterises many neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementias (FTD). Pathogenic mutations in TARDBP, the gene encoding TDP-43, can cause ALS and FTLD by increasing …
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Investigating the Effects of C9orf72 Haploinsufficiency on TDP-43 Pathology in ALS
… (FTD), transactive response DNA-binding protein 43 (TDP-43), a mainly nuclear DNA/RNA binding protein, is mislocalized to the cytoplasm of diseased neurons, where it forms abnormally phosphorylated and ubiquitinated inclusions, known as TDP-43 proteinopathy. TDP-43 proteinopathy is characteristic …
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UNDERSTANDING THE INFLUENCE OF TDP-43 LOSS-OF-FUNCTION ON NEUROTROPHIN SIGNALLING
TDP-43 is a DNA/RNA binding protein with a pathophysiological role in ALS and FTD, where it translocates out of the nucleus resulting in the loss of DNA/RNA regulatory functions. We found that TDP-43 knockdown, mutation and aggregation in neurons affects the proper splicing of the receptor Sortilin …
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A molecular analysis of the relation between TDP-43 and tau pathology
… RNA- binding protein, Tar DNA binding protein of 43 kDa (TDP-43) inclusions have been found in 20-35% of AD cases as well as other tauopathies. TDP-43 has roles RNA processing regulation including pre-mRNA splicing. Cytoplasmic inclusions ofTDP-43 result in a loss of nuclear TDP-43 and suggest a …
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Characterization of a Phosphomimetic Mutant of the ALS Associated Protein TDP-43
… response (TAR) DNA-binding protein 43 (TDP-43) is a natively dimeric 414-residue protein that is encoded by the human <em>TARDBP</em> gene that has important implications in the pathogenesis of the neurodegenerative disorders ALS, FTD, and CTE. TDP-43 has been found …
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Investigating the aggregation of TDP-43 in models of Amyotrophic Lateral Sclerosis
Trans-Activation Response DNA-binding Protein 43 (TDP-43) is a major constituent of proteinaceous inclusions characteristic of most forms of amyotrophic lateral sclerosis (ALS) and ubiquitin-positive frontotemporal lobar degeneration (FTLD). Normally a nuclear protein, TDP-43 translocates to the …
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A Study of alpha-Synuclein, Parkin and TDP-43 ; Proteins Implicated in Neurodegenerative Disease.
… patients with Alzheimer's disease (AD) harbour TDP-43 immunoreactive pathological changes in their brains. Again, ELISAs were developed to investigate whether TDP-43 was present, or indeed increased amounts detected, in plasma. Elevated levels of TDP-43 protein were detected in plasma of 46% …
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Using induced pluripotent stem cells to model glial-neuronal interactions in TDP-43 proteinopathies
… that Transactive response DNA-binding protein (TDP-43) is the dominant disease protein in both ALS and a sub-group of frontotemporal lobar degeneration (FTLDTDP). Moreover, the identification of TARDBP mutations in familial ALS confirms a mechanistic link between the observed mis-accumulation of …
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Ruolo della TDP-43 nella formazione dei granuli da stress nella Sclerosi Laterale Amiotrofica
… due to mutations in TARDBP, the gene encoding TDP-43, that is an ubiquitous nuclear protein that regulates mRNA functions and metabolism. Recent studies suggest that TDP-43 may regulates stress granules dynamics that are cytoplasmic structures composed of non-translating messenger …
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Characterization of the Dimerization and Salt Dependent Aggregation of the ALS-Linked Protein TDP-43
… response (TAR) DNA-binding protein 43 (TDP-43) is essential for RNA processing but can also form toxic cytoplasmic inclusions in neurons of patients with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). RNA-binding has been shown to have the potential …
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TDP-43 Is Directed to Stress Granules by Sorbitol, a Novel Physiological Osmotic and Oxidative Stressor
TDP-43, or TAR DNA-binding protein 43, is a pathological marker of a spectrum of neurodegenerative disorders including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U). TDP-43 is an RNA/DNA-binding protein implicated in …
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Characterization of Codon Optimized Wild Type TDP-43 Mediated Neurodegeneration in a Drosophila Model for ALS.
TAR DNA Binding Protein-43 (TDP-43) is known to mediate neurodegeneration associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration-ubiquitin (FTLD-U). The exact mechanism by which TDP-43 exerts toxicity in patient brains remains unclear. In a Drosophila model, we …
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Identification and characterization of a pathological TDP-43 variant in amyotrophic lateral sclerosis and frontotemporal lobar degeneration
TAR DNA-binding protein 43 (TDP-43) proteinopathy is a key pathological feature of a majority of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) cases. One key feature of pathological TDP-43 is the presence of lower molecular weight (MW) C-terminal species of 25 and …
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AGGREGATION MECHANISMS OF TDP-43 PROTEIN IN RESPONSE TO STRESS IN AMYOTROPHIC LATERAL SCLEROSIS AND THERAPEUTIC APPROACHES
… present in 97% of ALS cases, consists in TDP- 43 proteinopathy characterized by the accumulation of ubiquitinated and phosphorylated TAR DNA-binding protein 43 (TDP-43) in the cytoplasm, accompanied by the concomitant loss of TDP-43 splicing activity in the nucleus of affected neurons. The …
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