Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 2 of 2 for “"TDO2"”.
-
Synthetic Essentiality of Tdo2 In Apc-Mutated Colorectal Cancer
… identified Tryptophan 2,3-</p> <p>dioxygenase 2 (TDO2) as an SE gene for APC-deficient cancers.</p> <p>Mechanistically, APC loss results in TCF4/b-catenin-mediated activation of</p> <p>TDO2 gene transcription. TDO2 in turn activates the Kyn-AhR pathway</p> <p>which boosts glycolysis, promotes …
-
Stress and inflammation regulate the kynurenine pathway dioxygenases in a glia‐ and tissue‐specific manner
… and indoleamine 2,3-dioxygenases (DOs: Tdo2, Ido1 and Ido2). The DOs are rate-limiting for tryptophan metabolism by the Kynurenine Pathway. While accumulating evidence supports an interconnection between symptoms of depression and increased Kynurenine Pathway activity, the cellular …